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Literature summary for 3.1.7.1 extracted from
- Testicular sterols. V. Preparation and partial purification of a microsomal prenol pyrophosphate pyrophophohydrolase (1966), J. Biol. Chem., 241, 4043-4050.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ATP | 0.93 mM stimulates rate of hydrolysis | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-butanol | - |
Rattus norvegicus | |
| 3',5'-cAMP | - |
Rattus norvegicus | |
| arsenite | - |
Rattus norvegicus | |
| Co2+ | - |
Rattus norvegicus | |
| Cu2+ | - |
Rattus norvegicus | |
| dimethylallyl diphosphate | - |
Rattus norvegicus | |
| farnesoic acid | - |
Rattus norvegicus | |
| isopentenyl diphosphate | - |
Rattus norvegicus | |
| Mg2+ | loss of about 88% of activity at 10 mM | Rattus norvegicus | |
| Mn2+ | - |
Rattus norvegicus | |
| additional information | - |
Rattus norvegicus | |
| NaF | - |
Rattus norvegicus | |
| Plasma albumin | - |
Rattus norvegicus | |
| Zn2+ | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.7 | 1.2 | farnesol-diphosphate | - |
Rattus norvegicus | |
| 4 | 10 | dimethylallyl diphosphate | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | 3 mM stimulates the testicular enzyme 4-10fold | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prenyl diphosphate + H2O | Rattus norvegicus | - |
prenol + diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 125fold, partially purified | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
| testis | - |
Rattus norvegicus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| frozen preperations retained activity for 1 month | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| farnesyl diphosphate + H2O | - |
Rattus norvegicus | farnesol + diphosphate | - |
? | |
| glucose-6-phosphate + H2O | - |
Rattus norvegicus | glucose + phosphate | - |
? | |
| isopentenyl diphosphate + H2O | - |
Rattus norvegicus | isopentenol + diphosphate | - |
? | |
| mevalonate-5-phosphate + H2O | - |
Rattus norvegicus | mevalonate + phosphate | - |
? | |
| additional information | - |
Rattus norvegicus | ? | - |
? | |
| prenyl diphosphate + H2O | - |
Rattus norvegicus | prenol + diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| prenol pyrophosphate pyrophosphohydrolase | - |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
enzyme in crude acetone powder | Rattus norvegicus |
| 8.8 | - |
purified enzyme | Rattus norvegicus |
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