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Information on EC 3.1.7.1 - prenyl-diphosphatase
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3.1.7.1 prenyl-diphosphataseIUBMB Comments
Farnesyl diphosphate is the best substrate tested to date.
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Word Map
- 3.1.7.1
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fructose-1,6-diphosphatase
- fructose
- g6pase
- pepck
- glucose-6-phosphatase
- glucagon
- hypoglycemia
-
carboxykinase
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phosphofructokinase
- fructose-6-phosphate
-
1,6-diphosphatase
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ketonuria
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gluconeogenetic
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acidemia
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
allyl diphosphatase, farnesyl diphosphatase, FDPase, geranylgeranyl diphosphatase, GGDPase, More, prenol pyrophosphatase, prenol pyrophosphate pyrophosphohydrolase, prenol-pyrophosphatase, prenyl-pyrophosphatase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
farnesyl diphosphatase
FDPase
prenol-pyrophosphatase
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prenyl-pyrophosphatase
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additional information
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FDPase and GGDPase are two distinct allyl diphosphatases specifically hydrolyzing farnesyl diphosphate and geranylgeranyl diphosphate, respectively
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
prenyl diphosphate + H2O = prenol + diphosphate
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
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SYSTEMATIC NAME
IUBMB Comments
prenyl-diphosphate diphosphohydrolase
Farnesyl diphosphate is the best substrate tested to date.
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CAS REGISTRY NUMBER
COMMENTARY
37288-33-8
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
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isoprenoid pathway, FDPase may play an important role in regulating the isoprenoid biosynthetic pathway in cells exposed to UV-C radiation
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
isoprenoid pathway, FDPase may play an important role in regulating the isoprenoid biosynthetic pathway in cells exposed to UV-C radiation
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-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Ca2+
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decreases the rate of hydrolysis of several substrates at higher concentrations
geranyl diphosphate
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0.1 mM: 16% inhibition of soluble FDPase activity, 0.05 mM: 26% inhibition of microsomal FDPase activity, competitive
geranyl diphosphate
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FDPase activity, 0.1 mM, 50% inhibition, no inhibition of GGDPase
geranylgeranyl diphosphate
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0.05 mM, 16% inhibition of soluble and 38% inhibition of microsomal FDPase activity, competitive
Mg2+
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decreases the rate of hydrolysis of several substrates at higher concentrations
Mn2+
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decreases the rate of hydrolysis of several substrates at higher concentrations
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
isopentenyl diphosphate
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20% activation of soluble FDPase activity at 0.1 mM and of microsomal FDPase activity at 0.02 mM
p-nitrophenyl phosphate
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0.05 mM, 10% activation of soluble FDPase activity, 20% activation of microsomal FDPase activity
additional information
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FDPase and GGDPase are induced in rice seedlings irradiated with UV-C
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Diabetic Ketoacidosis
Gluconeogenesis defect presenting with resistant hyperglycemia and acidosis mimicking diabetic ketoacidosis.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Deficiency of glucose-6-phosphate dehydrogenase found in a case of hepatic fructose-1,6-diphosphatase deficiency.
Glucosephosphate Dehydrogenase Deficiency
Deficiency of glucose-6-phosphate dehydrogenase found in a case of hepatic fructose-1,6-diphosphatase deficiency.
glycerol kinase deficiency
Rapid, simplified and sensitive method for screening fructose-1,6-diphosphatase deficiency by analyzing urinary metabolites in urease/direct preparations and gas chromatography-mass spectrometry in the selected-ion monitoring mode.
Hyperglycemia
Fructose-6-phosphate substrate cycling and glucose and insulin regulation of gluconeogenesis in vivo.
Hyperglycemia
Fructose-6-phosphate substrate cycling and hormonal regulation of gluconeogenesis in vivo.
Hyperglycemia
Gluconeogenesis defect presenting with resistant hyperglycemia and acidosis mimicking diabetic ketoacidosis.
Hypoglycemia
Urinary organic metabolite screening of children with influenza-associated encephalopathy for inborn errors of metabolism using GC/MS.
Metabolic Diseases
Gluconeogenesis defect presenting with resistant hyperglycemia and acidosis mimicking diabetic ketoacidosis.
prenyl-diphosphatase deficiency
Deficiency of glucose-6-phosphate dehydrogenase found in a case of hepatic fructose-1,6-diphosphatase deficiency.
prenyl-diphosphatase deficiency
Fructose and glucagon loading in siblings with fructose-1,6-diphosphatase deficiency in fed state.
prenyl-diphosphatase deficiency
Fructose-1,6-Bisphosphatase Deficiency: A Case of a Successful Pregnancy by Closely Monitoring Metabolic Control.
prenyl-diphosphatase deficiency
Fructose-1,6-diphosphatase deficiency and glyceroluria: one possible etiology for GIS.
prenyl-diphosphatase deficiency
Fructose-1,6-diphosphatase deficiency: a treatable neurometabolic disorder.
prenyl-diphosphatase deficiency
Fructose-1,6-diphosphatase deficiency: diagnosis using leukocytes and detection of heterozygotes with radiochemical and spectrophotometric methods.
prenyl-diphosphatase deficiency
Gluconeogenesis defect presenting with resistant hyperglycemia and acidosis mimicking diabetic ketoacidosis.
prenyl-diphosphatase deficiency
Overanxious disorder with FDPase deficiency and developmental disability.
prenyl-diphosphatase deficiency
Rapid, simplified and sensitive method for screening fructose-1,6-diphosphatase deficiency by analyzing urinary metabolites in urease/direct preparations and gas chromatography-mass spectrometry in the selected-ion monitoring mode.
prenyl-diphosphatase deficiency
Urinary organic metabolite screening of children with influenza-associated encephalopathy for inborn errors of metabolism using GC/MS.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
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the relative specific activity of FDPase is much higher than the specific activity of GGDPase
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
35
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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lower soluble FDPase activity than in fruit and flower, highest microsomal FDPase activity
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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FDPase is constitutively expressed in the soluble and microsomal fractions, they may be distinct enzymes
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brenda
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FDPase is constitutively expressed in the soluble and microsomal fractions, they may be distinct enzymes
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brenda
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Perez, L.M.; Taucher, G.; Cori, O.
Hydrolysis of allylic phosphates by enzymes from the flavedo of Citrus sinensis
Phytochemistry
19
183-187
1980
Citrus sinensis
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brenda
Tsai, S.C.; Gaylor, J.L.
Testicular sterols. V. Preparation and partial purification of a microsomal prenol pyrophosphate pyrophophohydrolase
J. Biol. Chem.
241
4043-4050
1966
Rattus norvegicus
brenda
Ha, S.B.; Lee, D.E.; Lee, H.J.; Song, S.J.; Back, K.
Activities of soluble and microsomal farnesyl diphosphatases in Datura stramonium
Biol. Plant.
47
477-479
2003
Datura stramonium
-
brenda
Nah, J.; Song, S.J.; Back, K.
Partial characterization of farnesyl and geranylgeranyl diphosphatases induced in rice seedlings by UV-C irradiation
Plant Cell Physiol.
42
864-867
2001
Oryza sativa
brenda
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