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EC Tree
IUBMB Comments Farnesyl diphosphate is the best substrate tested to date.
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
allyl diphosphatase, farnesyl diphosphatase, FDPase, geranylgeranyl diphosphatase, GGDPase, More, prenol pyrophosphatase, prenol pyrophosphate pyrophosphohydrolase, prenol-pyrophosphatase, prenyl-pyrophosphatase,
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geranylgeranyl diphosphatase
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prenol pyrophosphatase
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prenol pyrophosphate pyrophosphohydrolase
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prenol-pyrophosphatase
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prenyl-pyrophosphatase
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additional information
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FDPase and GGDPase are two distinct allyl diphosphatases specifically hydrolyzing farnesyl diphosphate and geranylgeranyl diphosphate, respectively
farnesyl diphosphatase
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farnesyl diphosphatase
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FDPase
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prenyl diphosphate + H2O = prenol + diphosphate
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hydrolysis of phosphoric ester
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prenyl-diphosphate diphosphohydrolase
Farnesyl diphosphate is the best substrate tested to date.
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citronellyl diphosphate + H2O
citronellol + diphosphate
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-
-
?
copalyl diphosphate + H2O
copalol + diphosphate
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-
-
?
farnesyl diphosphate + H2O
farnesol + diphosphate
geranyl diphosphate + H2O
geraniol + diphosphate
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?
geranyl geranyl diphosphate + H2O
geranylgeraniol + diphosphate
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?
geranyl monophosphate + H2O
geraniol + phosphate
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?
geranylgeranyl diphosphate + H2O
geranylgeraniol + diphosphate
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GGDPase
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?
glucose-6-phosphate + H2O
glucose + phosphate
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?
isopentenyl diphosphate + H2O
isopentenol + diphosphate
mevalonate-5-phosphate + H2O
mevalonate + phosphate
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-
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?
neryl diphosphate + H2O
nerol + diphosphate
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-
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?
neryl monophosphate + H2O
nerol + phosphate
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?
prenyl diphosphate + H2O
prenol + diphosphate
additional information
?
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farnesyl diphosphate + H2O
farnesol + diphosphate
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?
farnesyl diphosphate + H2O
farnesol + diphosphate
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?
farnesyl diphosphate + H2O
farnesol + diphosphate
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FDPase
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?
farnesyl diphosphate + H2O
farnesol + diphosphate
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?
isopentenyl diphosphate + H2O
isopentenol + diphosphate
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?
isopentenyl diphosphate + H2O
isopentenol + diphosphate
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?
prenyl diphosphate + H2O
prenol + diphosphate
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?
prenyl diphosphate + H2O
prenol + diphosphate
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?
additional information
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isoprenoid pathway, FDPase may play an important role in regulating the isoprenoid biosynthetic pathway in cells exposed to UV-C radiation
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?
additional information
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?
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prenyl diphosphate + H2O
prenol + diphosphate
additional information
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isoprenoid pathway, FDPase may play an important role in regulating the isoprenoid biosynthetic pathway in cells exposed to UV-C radiation
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?
prenyl diphosphate + H2O
prenol + diphosphate
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?
prenyl diphosphate + H2O
prenol + diphosphate
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?
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Mg2+
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3 mM stimulates the testicular enzyme 4-10fold
additional information
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Mg2+-independent
additional information
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FDPase and GGDPase are both Mg2+-independent
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5,5'-dithiobis-(2-nitrobenzoic acid)
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ATP
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inhibits NPP and GPP hydrolysis
Ca2+
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decreases the rate of hydrolysis of several substrates at higher concentrations
farnesyl diphosphate
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GGDPase activity, 0.1 mM, 50% inhibition
geranylgeranyl diphosphate
isopentenol-diphosphate
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phosphate
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inhibits NPP and GPP hydrolysis
geranyl diphosphate
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0.1 mM: 16% inhibition of soluble FDPase activity, 0.05 mM: 26% inhibition of microsomal FDPase activity, competitive
geranyl diphosphate
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FDPase activity, 0.1 mM, 50% inhibition, no inhibition of GGDPase
geranylgeranyl diphosphate
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0.05 mM, 16% inhibition of soluble and 38% inhibition of microsomal FDPase activity, competitive
geranylgeranyl diphosphate
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FDPase activity, 0.005 mM, 50% inhibition
isopentenyl diphosphate
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GGDPase activity, 0.05 mM, 50% inhibition
isopentenyl diphosphate
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Mg2+
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decreases the rate of hydrolysis of several substrates at higher concentrations
Mg2+
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loss of about 88% of activity at 10 mM
Mn2+
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decreases the rate of hydrolysis of several substrates at higher concentrations
additional information
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not inhibited by ATP or p-nitrophenyl phosphate
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additional information
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isopentenyl diphosphate
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20% activation of soluble FDPase activity at 0.1 mM and of microsomal FDPase activity at 0.02 mM
p-nitrophenyl phosphate
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0.05 mM, 10% activation of soluble FDPase activity, 20% activation of microsomal FDPase activity
additional information
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FDPase and GGDPase are induced in rice seedlings irradiated with UV-C
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ATP
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0.05 mM, 8% activation of soluble FDPase activity
ATP
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0.93 mM stimulates rate of hydrolysis
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Diabetic Ketoacidosis
Gluconeogenesis defect presenting with resistant hyperglycemia and acidosis mimicking diabetic ketoacidosis.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Deficiency of glucose-6-phosphate dehydrogenase found in a case of hepatic fructose-1,6-diphosphatase deficiency.
Glucosephosphate Dehydrogenase Deficiency
Deficiency of glucose-6-phosphate dehydrogenase found in a case of hepatic fructose-1,6-diphosphatase deficiency.
glycerol kinase deficiency
Rapid, simplified and sensitive method for screening fructose-1,6-diphosphatase deficiency by analyzing urinary metabolites in urease/direct preparations and gas chromatography-mass spectrometry in the selected-ion monitoring mode.
Hyperglycemia
Fructose-6-phosphate substrate cycling and glucose and insulin regulation of gluconeogenesis in vivo.
Hyperglycemia
Fructose-6-phosphate substrate cycling and hormonal regulation of gluconeogenesis in vivo.
Hyperglycemia
Gluconeogenesis defect presenting with resistant hyperglycemia and acidosis mimicking diabetic ketoacidosis.
Hypoglycemia
Urinary organic metabolite screening of children with influenza-associated encephalopathy for inborn errors of metabolism using GC/MS.
Metabolic Diseases
Gluconeogenesis defect presenting with resistant hyperglycemia and acidosis mimicking diabetic ketoacidosis.
prenyl-diphosphatase deficiency
Deficiency of glucose-6-phosphate dehydrogenase found in a case of hepatic fructose-1,6-diphosphatase deficiency.
prenyl-diphosphatase deficiency
Fructose and glucagon loading in siblings with fructose-1,6-diphosphatase deficiency in fed state.
prenyl-diphosphatase deficiency
Fructose-1,6-Bisphosphatase Deficiency: A Case of a Successful Pregnancy by Closely Monitoring Metabolic Control.
prenyl-diphosphatase deficiency
Fructose-1,6-diphosphatase deficiency and glyceroluria: one possible etiology for GIS.
prenyl-diphosphatase deficiency
Fructose-1,6-diphosphatase deficiency: a treatable neurometabolic disorder.
prenyl-diphosphatase deficiency
Fructose-1,6-diphosphatase deficiency: diagnosis using leukocytes and detection of heterozygotes with radiochemical and spectrophotometric methods.
prenyl-diphosphatase deficiency
Gluconeogenesis defect presenting with resistant hyperglycemia and acidosis mimicking diabetic ketoacidosis.
prenyl-diphosphatase deficiency
Overanxious disorder with FDPase deficiency and developmental disability.
prenyl-diphosphatase deficiency
Rapid, simplified and sensitive method for screening fructose-1,6-diphosphatase deficiency by analyzing urinary metabolites in urease/direct preparations and gas chromatography-mass spectrometry in the selected-ion monitoring mode.
prenyl-diphosphatase deficiency
Urinary organic metabolite screening of children with influenza-associated encephalopathy for inborn errors of metabolism using GC/MS.
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0.7 - 1.2
farnesol-diphosphate
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4 - 10
isopentenol-diphosphate
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additional information
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additional information
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the relative specific activity of FDPase is much higher than the specific activity of GGDPase
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7.8
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enzyme in crude acetone powder
6
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for p-nitrophenylphosphate or AMP hydrolysis
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35
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assay at
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brenda
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brenda
cv. Nakdong
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brenda
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brenda
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brenda
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highest soluble FDPase activity in fruit and flower
brenda
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highest soluble FDPase activity in fruit and flower
brenda
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lower soluble FDPase activity than in fruit and flower
brenda
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brenda
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lower soluble FDPase activity than in fruit and flower, highest microsomal FDPase activity
brenda
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brenda
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brenda
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FDPase is constitutively expressed in the soluble and microsomal fractions, they may be distinct enzymes
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brenda
additional information
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not in the cytoplasm
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brenda
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FDPase is constitutively expressed in the soluble and microsomal fractions, they may be distinct enzymes
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brenda
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FDPase and GGDPase
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brenda
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brenda
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A0A084J3F2_BACMY
179
0
20174
TrEMBL
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A0A653Q3J0_9BACI
182
0
20522
TrEMBL
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A0A653SQK4_9BACI
185
0
21078
TrEMBL
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A0A654ARC8_9STAP
180
0
20681
TrEMBL
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A0A653IF62_9BACL
176
0
19748
TrEMBL
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A0A383RCL6_PAEAL
193
0
21384
TrEMBL
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A0A6F9EA37_9BACL
182
0
19955
TrEMBL
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A0A483BS25_OENOE
186
0
21020
TrEMBL
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A0A653PI49_9BACL
176
0
19970
TrEMBL
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-20°C, 1 year as a freeze dried powder
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4°C, in 50 mM Tris-HCL, pH 7, half-life of 21 days
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frozen preperations retained activity for 1 month
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125fold, partially purified
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3000fold, partially purified, phosphocellulose fraction
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Perez, L.M.; Taucher, G.; Cori, O.
Hydrolysis of allylic phosphates by enzymes from the flavedo of Citrus sinensis
Phytochemistry
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183-187
1980
Citrus sinensis
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brenda
Tsai, S.C.; Gaylor, J.L.
Testicular sterols. V. Preparation and partial purification of a microsomal prenol pyrophosphate pyrophophohydrolase
J. Biol. Chem.
241
4043-4050
1966
Rattus norvegicus
brenda
Ha, S.B.; Lee, D.E.; Lee, H.J.; Song, S.J.; Back, K.
Activities of soluble and microsomal farnesyl diphosphatases in Datura stramonium
Biol. Plant.
47
477-479
2003
Datura stramonium
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brenda
Nah, J.; Song, S.J.; Back, K.
Partial characterization of farnesyl and geranylgeranyl diphosphatases induced in rice seedlings by UV-C irradiation
Plant Cell Physiol.
42
864-867
2001
Oryza sativa
brenda
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3.1.7.1 prenyl-diphosphatase
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