Application | Comment | Organism |
---|---|---|
medicine | the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice | Rattus norvegicus |
medicine | the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice | Homo sapiens |
medicine | the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P80108 | - |
- |
Mus musculus | Q7TNZ4 | - |
- |
Rattus norvegicus | Q8R2H5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | primary hepatocyte | Rattus norvegicus | - |
liver | highest expression level | Mus musculus | - |
serum | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Gpld1 | - |
Rattus norvegicus |
Gpld1 | - |
Homo sapiens |
Gpld1 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice | up |
Homo sapiens | the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice | up |
Mus musculus | the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice | up |
General Information | Comment | Organism |
---|---|---|
physiological function | GPI-PLD directly regulates intracellular diacylglycerol content in primary hepatocytes. Serum GPI-PLD levels are strongly and independently associated with serum alanine transaminase and triglyceride levels in male subjects with metabolic syndrome | Rattus norvegicus |
physiological function | mice lacking GPI-PLD exhibit glucose intolerance and hepatic steatosis under high-fat and high-sucrose diet. Diacylglycerol content is significantly decreased, and protein kinase PKCepsilon activity is suppressed in the livers of knockout mice | Mus musculus |
physiological function | serum GPI-PLD level is strongly and independently associated with serum alanine transaminase and triglyceride levels in human male subjects | Homo sapiens |