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Information on EC 3.1.4.50 - glycosylphosphatidylinositol phospholipase D

for references in articles please use BRENDA:EC3.1.4.50

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IUBMB Comments

This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors, but does so by hydrolysis, whereas glycosylphosphatidylinositol diacylglycerol-lyase (EC 4.6.1.14) does so by elimination. It acts on plasma membranes only after solubilization of the substrate with detergents or solvents, but it may act on intracellular membranes.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
gpi-pld, glycosylphosphatidylinositol-specific phospholipase d, gpld1, gpi-specific phospholipase d, glycosylphosphatidylinositol phospholipase d, pi-g pld, phosphatidylinositol-specific phospholipase d, glycosylphosphatidylinositol-phospholipase d, glycoprotein phospholipase d, phosphatidylinositol phospholipase d, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + 3-sn-phosphatidate
show the reaction diagram
this enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphosphatidylinositol anchors, but does so by hydrolysis, whereas glycosylphosphatidylinositol diacylglycerol-lyase, EC 4.6.1.14, does so by elimination. It acts on plasma membranes only after solubilization of the substrate with detergents or solvents, but it may act on intracellular membranes
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