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Information on EC 3.1.4.50 - glycosylphosphatidylinositol phospholipase D

for references in articles please use BRENDA:EC3.1.4.50
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IUBMB Comments
This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors, but does so by hydrolysis, whereas glycosylphosphatidylinositol diacylglycerol-lyase (EC 4.6.1.14) does so by elimination. It acts on plasma membranes only after solubilization of the substrate with detergents or solvents, but it may act on intracellular membranes.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
glycoprotein phospholipase D, glycosylphophatidylinositol-specific phospholipase D, glycosylphosphatidylinositol-phospholipase D, glycosylphosphatidylinositol-specific phospholipase D, GPI-PDL, GPI-PLD, GPI-specific phospholipase D, Gpld1, phosphatidylinositol phospholipase D, phosphatidylinositol-specific phospholipase D, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + 3-sn-phosphatidate
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this enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphosphatidylinositol anchors, but does so by hydrolysis, whereas glycosylphosphatidylinositol diacylglycerol-lyase, EC 4.6.1.14, does so by elimination. It acts on plasma membranes only after solubilization of the substrate with detergents or solvents, but it may act on intracellular membranes
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