Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | PLD1 is activated by oxidative stress in various cell lines. Reactive oxygen species-induced PLD1 activation involves PKC and tyrosine kinases in various mammalian cell systems | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-butanol | - |
Homo sapiens | |
additional information | inhibition of PLD1 by pharmacological inhibitors blocks PKD1 activation under oxidative stress | Homo sapiens | |
propranolol | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | - |
Homo sapiens | 5794 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
additional information | PLD1 is located at most cellular organelles, including the perinuclear region, mitochondria and the Golgi apparatus | Homo sapiens | - |
- |
perinuclear space | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | PLD1 mediates the reactive oxygen species-induced increase in diacylglycerol, which facilitates PKD1 localization to the mitochondria and its activation. Diacylglycerol, to which PKD1 is recruited, is formed downstream of phospholipase D1 and is required for PKD1 localization in the mitochondria and well as activation under oxidative stress, overview. Role for PLD1-induced DAG as a competent second messenger at the mitochondria that relays ROS to PKD1-mediated mitochondria-to-nucleus signaling | ? | - |
? | |
phosphatidylcholine + H2O | Homo sapiens | - |
choline + phosphatidic acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
additional information | ubiquitous expression of PLD1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PLD1 mediates the reactive oxygen species-induced increase in diacylglycerol, which facilitates PKD1 localization to the mitochondria and its activation. Diacylglycerol, to which PKD1 is recruited, is formed downstream of phospholipase D1 and is required for PKD1 localization in the mitochondria and well as activation under oxidative stress, overview. Role for PLD1-induced DAG as a competent second messenger at the mitochondria that relays ROS to PKD1-mediated mitochondria-to-nucleus signaling | Homo sapiens | ? | - |
? | |
phosphatidylcholine + H2O | - |
Homo sapiens | choline + phosphatidic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phospholipase D1 | - |
Homo sapiens |
PLD1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | lipase-inactive PLD1 or inhibition of PLD1 by pharmacological inhibitors blocks PKD1 activation under oxidative stress | Homo sapiens |
physiological function | role for PLD1-induced diacylglycerol as a competent second messenger at the mitochondria that relays ROS to PKD1-mediated mitochondria-to-nucleus signaling, overview | Homo sapiens |