Literature summary for 3.1.4.4 extracted from

Birbes, H.; Zeiller, C.; Komati, H.; Nemoz, G.; Lagarde, M.; Prigent, A.F.
Phospholipase D protects ECV304 cells against TNFalpha-induced apoptosis (2006), FEBS Lett., 580, 6224-6232.

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Protein Variants

Protein Variants	Comment	Organism
additional information	induction of apoptosis by co-treatment using tumor necrosis factor alpha and cycloheximide induces enzyme activity after 1 h whereas both enzyme activity and isoform PLD1 protein are strongly decreased after 24 h. Tumor necrosis factor alpha/cycloheximide-induced cell death is significantly lowered in cells overexpressing isoform PLD1 or by exogenous bacterial enzyme. Cells depleted in enzyme proteins by siRNA treatment exhibit higher susceptibility to apoptosis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
ECV-304 cell	induction of apoptosis by co-treatment using tumor necrosis factor alpha and cycloheximide induces a robust increase in ceramide levels after 16 h. Enzyme activity is increased after 1 h whereas both enzyme activity and isoform PLD1 protein are strongly decreased after 24 h. Tumor necrosis factor alpha/cycloheximide-induced cell death is significantly lowered in cells overexpressing isoform PLD1 or by exogenous bacterial enzyme	Homo sapiens	-

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Release 2023.1 (January 2023)