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Literature summary for 3.1.4.35 extracted from
- Up-regulation of 3',5'-cyclic guanosine monophosphate-specific phosphodiesterase in the porcine cumulus-oocyte complex affects steroidogenesis during in vitro maturation (2008), Endocrinology, 149, 5568-5576.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-isobutyl-1-methylxanthine | - |
Sus scrofa |  |
| sildenafil | 0.01 mM sildenafil inhibits 84% and 68% of the activity measured in detergent-resistant membranes and detergent-soluble fractions, respectively; 0.01 mM sildenafil inhibits 84% and 68% of the activity measured in detergent-resistant membranes and detergent-soluble fractions, respectively | Sus scrofa | |
| zaprinast | - |
Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | approximately 37% of cGMP degradation activity is localized in the detergent-resistant membrane | Sus scrofa | 16020 | - |
| soluble | approximately 45% of cGMP degradation activity is localized in the detergent-soluble fractions | Sus scrofa | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
PDE6C immunodetection shows two bands at about 60000 and 85000 Da, SDS-PAGE | Sus scrofa |
| 85000 | - |
PDE6C immunodetection shows two bands at about 60000 and 85000 Da, SDS-PAGE | Sus scrofa |
| 100000 | - |
about 100000 Da, PDE5A, SDS-PAGE | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
| Sus scrofa | Q864F1 | fragment | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| oocyte | - |
Sus scrofa | - |
| ovarian cumulus cell | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3',5'-cGMP + H2O | - |
Sus scrofa | 5'-GMP | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3',5'-cyclic guanosine monophosphate-specific phosphodiesterase | - |
Sus scrofa |
| GMP-PDE | - |
Sus scrofa |
| PDE5A | - |
Sus scrofa |
| PDE6C | - |
Sus scrofa |
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