Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cGMP | preincubation with cGMP increases catalytic activity for cGMP degradation, this increase may be caused by binding of cGMP to either the PDE5 allosteric sites, catalytic sites, or both. Full-length GAF-B subdomain conjoined with catalytic domain is sufficient for this conversion | Bos taurus |
Cloned (Comment) | Organism |
---|---|
expression in Sf9 system | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sildenafil | preincubation with cGMP increases catalytic activity for cGMP degradation, but also for binding of inhibitor | Bos taurus | |
tadalafil | preincubation with cGMP increases catalytic activity for cGMP degradation, but also for binding of inhibitor | Bos taurus | |
vardenafil | preincubation with cGMP increases catalytic activity for cGMP degradation, but also for binding of inhibitor | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Bos taurus | preincubation with cGMP increases catalytic activity for cGMP degradation, thus elevated cellular cGMP initiates a physiological negative feedback on the cGMP pathway by increasing the affinity of the PDE5 catalytic site for cGMP | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
isoform PDE5 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | preincubation with cGMP increases catalytic activity for cGMP degradation, thus elevated cellular cGMP initiates a physiological negative feedback on the cGMP pathway by increasing the affinity of the PDE5 catalytic site for cGMP | Bos taurus | ? | - |
? |