Cloned (Comment) | Organism |
---|---|
baculovirus-expressed PDE5 in Sf9 cells | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(-)-6-(3-(3-cyclopropyl-3-((1R,2R)-2-hydroxycyclohexyl)ureido)-propoxy)-2(1H)-quinolinone | IC50: 0.0121 mM, PDE5 | Bos taurus | |
2-cyclohexyl-2-methyl-N1-[3-(2-oxo-1,2-dihydro-6-quinolyl,oxy)propyl]-1-hydrazinecarboxamide | IC50: 0.0027 mM, PDE5 | Bos taurus | |
6-(3-(3-cyclooctyl-3-((1R,2R)-2-hydroxycyclohexyl)ureido)-propoxy)-2(1H)-quinolinone | IC50: 0.0025 mM, PDE5 | Bos taurus | |
amrinone | IC50: 0.2296 mM, PDE5 | Bos taurus | |
Cilostamide | IC50: 0.0152 mM, PDE5 | Bos taurus | |
cilostazol | IC50: 0.0044 mM, PDE5 | Bos taurus | |
dipyridamole | IC50: 0.00026 mM, PDE5 | Bos taurus | |
Milrinone | IC50: 0.0491 mM, PDE5 | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00098 | - |
3',5'-cAMP | 30°C, pH 8.0, PDE5 | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | - |
Bos taurus | 5'-AMP | - |
? | |
3',5'-cGMP + H2O | PDE5 | Bos taurus | guanosine 5'-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE5 | - |
Bos taurus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00026 | - |
IC50: 0.00026 mM, PDE5 | Bos taurus | dipyridamole | |
0.0025 | - |
IC50: 0.0025 mM, PDE5 | Bos taurus | 6-(3-(3-cyclooctyl-3-((1R,2R)-2-hydroxycyclohexyl)ureido)-propoxy)-2(1H)-quinolinone | |
0.0027 | - |
IC50: 0.0027 mM, PDE5 | Bos taurus | 2-cyclohexyl-2-methyl-N1-[3-(2-oxo-1,2-dihydro-6-quinolyl,oxy)propyl]-1-hydrazinecarboxamide | |
0.0044 | - |
IC50: 0.0044 mM, PDE5 | Bos taurus | cilostazol | |
0.0121 | - |
IC50: 0.0121 mM, PDE5 | Bos taurus | (-)-6-(3-(3-cyclopropyl-3-((1R,2R)-2-hydroxycyclohexyl)ureido)-propoxy)-2(1H)-quinolinone | |
0.0152 | - |
IC50: 0.0152 mM, PDE5 | Bos taurus | Cilostamide | |
0.0491 | - |
IC50: 0.0491 mM, PDE5 | Bos taurus | Milrinone | |
0.2296 | - |
IC50: 0.2296 mM, PDE5 | Bos taurus | amrinone |