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Literature summary for 3.1.4.35 extracted from

  • Methven, P.; Lemon, M.; Bhoola, K.
    The metabolism of cyclic nucleotides in the guinea-pig pancreas. Cyclic AMP phosphodiesterase and cyclic GMP phosphodiesterase (1980), Biochem. J., 186, 491-498.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.35

General Stability

General Stability Organism
traysylol, protease inhibitor, stabilization Cavia porcellus

Inhibitors

Inhibitors Comment Organism Structure
3',5'-cAMP
-
 Cavia porcellus
3-isobutyl-1-methylxanthine
-
 Cavia porcellus
Ca2+ inhibitory at 1 mM together with Mg2+ below 0.1 mM Cavia porcellus
Caffeine
-
 Cavia porcellus
EDTA
-
 Cavia porcellus
Mg2+ inhibitory below 0.1 mM together with Ca2+ at 1 mM Cavia porcellus
papaverine
-
 Cavia porcellus
theophylline
-
 Cavia porcellus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00032
-
 3',5'-cGMP low affinity components Cavia porcellus
0.0319
-
 3',5'-cGMP high affinity components Cavia porcellus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol subcelluar distribution Cavia porcellus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activatory at 0.1-1 mM Cavia porcellus
Mg2+
-
 Cavia porcellus
Mn2+
-
 Cavia porcellus

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
 Cavia porcellus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cGMP + H2O
-
 Cavia porcellus 5'-GMP
-
 ?