Activating Compound | Comment | Organism | Structure |
---|---|---|---|
H2O2 | exogenous H2O2 increases enzyme activity | Rattus norvegicus | |
silica particle | enzyme activity in macrophage increases significantly upon exposure to silica particles. Increase in activity is inhibited by Mn(III)tetrakis(4-benzoic acid)porphyrin chloride | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | isoform PC-PLC plays a critical role in the silica-associated inflammatory response of alveolar macrophage | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D609 | inhibition of isoform PC-PLC blocks the silica-stimulated induction of TNF-alpha and interleukin-1beta | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | enzyme is regulated through redox- and calcium-dependent manners in alveolar macrophage | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | alveolar macrophage | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme is regulated through redox- and calcium-dependent manners in alveolar macrophage | Rattus norvegicus | ? | - |
? |