Crystallization (Comment) | Organism |
---|---|
1.9 A resolution, R-factor of 15.7% | Bacillus cereus |
crystal structure of a complex between the enzyme and a competitive inhibitor. 1.9 A resolution, R-factor of 15.7% | Bacillus cereus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3(S),4-dihexanoylbutyl-1-phosphonycholine | non-hydrolyzable, competitive inhibitor of bacterial PLC, analog of the natural phospholipid substrate, binds with its phosphonyl group to the three Zn-ions in the active site of the enzyme | Bacillus cereus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.38 | - |
phosphatidylcholine | water-soluble substrate | Bacillus cereus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Bacillus cereus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | metalloenzyme | Bacillus cereus | |
Zn2+ | 3 Zn2+ ions in active site | Bacillus cereus | |
Zn2+ | in the active site of the enzyme | Bacillus cereus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus cereus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bacillus cereus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + H2O | - |
Bacillus cereus | 1,2-diacylglycerol + choline phosphate | - |
? | |
phosphatidylethanolamine + H2O | - |
Bacillus cereus | phosphorylethanolamine + diacylglycerol | - |
? | |
phosphatidylserine + H2O | - |
Bacillus cereus | phosphorylserine + diacylglycerol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PC-PLC | - |
Bacillus cereus |
phospholipase C | - |
Bacillus cereus |
PLC | - |
Bacillus cereus |
PLCBC | - |
Bacillus cereus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.47 | - |
3(S),4-dihexanoylbutyl-1-phosphonycholine | - |
Bacillus cereus |