Literature summary for 3.1.4.11 extracted from

Suh, P.G.; Park, J.I.; Manzoli, L.; Cocco, L.; Peak, J.C.; Katan, M.; Fukami, K.; Kataoka, T.; Yun, S.; Ryu, S.H.
Multiple roles of phosphoinositide-specific phospholipase C isozymes (2008), BMB Rep., 41, 415-434.

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	-	Mammalia

Organism

Organism	UniProt	Comment	Textmining
Mammalia	-	13 mammalian PLC isozymes have been identified	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
anterior pituitary	PLC-gamma2 mRNA is expressed in the limited areas of anterior pituitary and cerebellar Purkinje and granule cells	Mammalia	-
astrocyte	PLC-gamma1 mRNA is widely detected in various tissues. It is abundantly expressed in embryonal cortical structures, neurons, oligodendrocytes and astrocytes	Mammalia	-
brain	PLC-gamma1, PLC-delta3, PLC-delta1, PLC-delta4 and PLC-eta mRNA is expressed in. PLC-beta3 is found in the brain, liver, and parotid gland	Mammalia	-
cerebellar Purkinje cell	PLC-gamma2 mRNA is expressed in the limited areas of anterior pituitary and cerebellar Purkinje and granule cells	Mammalia	-
cerebellum	PLC-beta4 is present at the highest level in the cerebellum and retina	Mammalia	-
cerebral cortex	PLC-beta1 is highly expressed in the cerebral cortex and hippocampus	Mammalia	-
colon	PLC-eta mRNA is expressed in colon	Mammalia	-
embryo	PLC-gamma1	Mammalia	-
embryo	PLC-gamma1 mRNA is widely detected in various tissues. It is abundantly expressed in embryonal cortical structures, neurons, oligodendrocytes and astrocytes	Mammalia	-
granule cell	PLC-gamma2 mRNA is expressed in the limited areas of anterior pituitary and cerebellar Purkinje and granule cells	Mammalia	-
heart	highest expression of PLC-eta detected in heart. PLC-delta3 is present in heart. PLC-delta1 is present in high abundancy in the brain, heart, lung, skeletal muscle and testis	Mammalia	-
hematopoietic cell	limited expression of PLC-beta2 in hematopoietic cells	Mammalia	-
hippocampus	PLC-beta1 is highly expressed in the cerebral cortex and hippocampus	Mammalia	-
kidney	PLC-delta4 mRNA is expressed in various tissues with the highest levels detected selectively in the brain, skeletal muscle, testis and kidney	Mammalia	-
liver	PLC-beta3 is found in the brain, liver, and parotid gland	Mammalia	-
lung	PLC-eta mRNA is expressed in lung. PLC-delta1 is present in high abundancy in the brain, heart, lung, skeletal muscle and testis	Mammalia	-
lymph node	PLC-gamma2	Mammalia	-
neuron	PLC-gamma1 mRNA is widely detected in various tissues. It is abundantly expressed in embryonal cortical structures, neurons, oligodendrocytes and astrocytes	Mammalia	-
oligodendrocyte	PLC-gamma1 mRNA is widely detected in various tissues. It is abundantly expressed in embryonal cortical structures, neurons, oligodendrocytes and astrocytes	Mammalia	-
pancreas	PLC-delta3	Mammalia	-
parotid gland	PLC-beta3 is found in the brain, liver, and parotid gland	Mammalia	-
reproductive system	PLC-delta1	Mammalia	-
retina	PLC-beta4 is present at the highest level in the cerebellum and retina	Mammalia	-
skeletal muscle	PLC-delta4 mRNA is expressed in skeletal muscle. PLC-delta3 is present in skeletal muscle. PLC-delta1 is present in high abundancy in the brain, heart, lung, skeletal muscle and testis	Mammalia	-
testis	PLC-delta4 mRNA is expressed in testis. PLC-delta1 is present in high abundancy in the brain, heart, lung, skeletal muscle and testis	Mammalia	-
thymus	and connective tissue, PLC-delta1	Mammalia	-

Synonyms

Synonyms	Comment	Organism
phosphoinositide-specific phospholipase C	-	Mammalia
PLC-beta	-	Mammalia
PLC-delta	-	Mammalia
PLC-epsilon	-	Mammalia
PLC-eta	-	Mammalia
PLC-gamma	-	Mammalia
PLC-zeta	-	Mammalia