Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | reduction in phospholipase C may be critical in the pathophysiology of depression and other stress-related disorders | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain cortex | frontal cortex, single inescapable shock reduces PI-PLC activity in the frontal cortex and hippocampus of learned helplessness rats. Repeated inescapable shock not only reduced PI-PLC activity but also selectively decreases the expression of PLCbeta1 and PLCgamma1 isozymes | Rattus norvegicus | - |
hippocampus | single inescapable shock reduces PI-PLC activity in the frontal cortex and hippocampus of learned helplessness rats. Repeated inescapable shock not only reduced PI-PLC activity but also selectively decreases the expression of PLCbeta1 and PLCgamma1 isozymes | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Rattus norvegicus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
additional information | reduction in phospholipase C may be critical in the pathophysiology of depression and other stress-related disorders | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PI-PLC | - |
Rattus norvegicus |
PLCbeta1 | - |
Rattus norvegicus |
PLCgamma1 | - |
Rattus norvegicus |