Literature summary for 3.1.3.86 extracted from

Hoekstra, E.; Das, A.M.; Willemsen, M.; Swets, M.; Kuppen, P.J.; van der Woude, C.J.; Bruno, M.J.; Shah, J.P.; Ten Hagen, T.L.; Chisholm, J.D.; Kerr, W.G.; Peppelenbosch, M.P.; Fuhler, G.M.
Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation (2016), Oncotarget, 7, 73525-73540 .

Search for more literature for 3.1.3.86

Inhibitors

Inhibitors	Comment	Organism	Structure
2-[1-(2,4-dichlorobenzyl)-2-methyl-5-(methylmercapto)-1H-indol-3-yl] ethanaminium chloride	-	Homo sapiens
2-[1-(2-chlorobenzyl)-2-methyl-5-(methylmercapto)-1H-indol-3-yl] ethanaminium chloride	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O	Homo sapiens	-	1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15357	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Caco-2 cell	-	Homo sapiens	-
Colo-320 cell	-	Homo sapiens	-
colonic epithelial cell	-	Homo sapiens	-
colorectal cancer cell	-	Homo sapiens	-
HCT-116 cell	-	Homo sapiens	-
LS-174T cell	-	Homo sapiens	-
RKO cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O	-	Homo sapiens	1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
INPPL1	-	Homo sapiens
SH2-domain-containing 5 inositol phosphatase	-	Homo sapiens
SHIP2	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	enzyme expression is increased in colorectal cancer tissue in comparison to adjacent normal tissue	up

General Information

General Information	Comment	Organism
malfunction	isoform SHIP2 inhibition or knockdown inhibits cell migration and reduces phosphorylated protein kinase B levels, resulting in sensitivity to chemotherapeutics	Homo sapiens
physiological function	isoform SHIP2 functions as oncogene in colorectal cancer by regulating protein kinase B activation	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)