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Information on EC 3.1.3.86 - phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

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IUBMB Comments
This enzyme hydroylses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward (PtdIns(1,3,4,5)P4) . The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
ship-1, sh2-containing inositol phosphatase, sh2 domain-containing inositol 5-phosphatase, ptdins(3,4,5)p3 5-phosphatase, ptdins(3,4,5)p3 phosphatase, sh2 domain containing inositol 5-phosphatase, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1, sh2 domain-containing inositol 5-phosphatase 2, 75 kda 5-phosphatase, phosphatidylinositol (3,4,5)-trisphosphate 5-phosphatase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
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PATHWAY SOURCE
PATHWAYS
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