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Literature summary for 3.1.3.86 extracted from

  • Ghosh, S.; Scozzaro, S.; Ramos, A.R.; Delcambre, S.; Chevalier, C.; Krejci, P.; Erneux, C.
    Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells (2018), J. Cell Sci., 131, jcs216408.
    View publication on PubMed
Search for more literature for 3.1.3.86

Inhibitors

Inhibitors Comment Organism Structure
AS1949490
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O Homo sapiens
-
 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Homo sapiens
-
 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15357
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
BT-20 cell
-
 Homo sapiens
-
BT-549 cell
-
 Homo sapiens
-
HCC-38 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
MDA-MB-468 cell
-
 Homo sapiens
-
T-47D cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 150000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
INPPL1
-
 Homo sapiens
SHIP2
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction apoptosis in MDA-MB-231 cells is increased in SHIP2-depleted cells as compared to control cells Homo sapiens