Literature summary for 3.1.3.86 extracted from

Gorgani-Firuzjaee, S.; Adeli, K.; Meshkani, R.
Inhibition of SH2-domain-containing inositol 5-phosphatase (SHIP2) ameliorates palmitate induced-apoptosis through regulating Akt/FOXO1 pathway and ROS production in HepG2 cells (2015), Biochem. Biophys. Res. Commun., 464, 441-446 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15357	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293T cell	-	Homo sapiens	-
Hep-G2 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
SHIP2	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	overexpression of the wild-ype SHIP2 gene leads to a higher total lipid content (28%) compared to control, whereas overexpression of the dominant negative SHIP2 gene reduces total lipid content in oleate treated cells by 40%. Overexpression of SHIP2 wild-type also leads to a significant increase in both secretion of apoB100 containing lipoproteins and de novo lipogenesis. Overexpression of the SHIP2 dominant negative gene prevents oleate-induced de novo lipogenesis and secretion of apoB100 containing lipoproteins in HepG2 cells	Homo sapiens

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Release 2023.1 (January 2023)