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Literature summary for 3.1.3.62 extracted from

  • Höer, A.; Höer, D.; Oberdisse, E.
    Properties of a soluble inositol 1,3,4,5-tetrakisphosphate 3-phosphatase from porcine brain (1990), Biochem. J., 270, 715-719.
    View publication on PubMed
Search for more literature for 3.1.3.62

Inhibitors

Inhibitors Comment Organism Structure
ATP weak Sus scrofa
CTP more effective inhibitor than GTP Sus scrofa
GTP marked inhibition Sus scrofa
Inositol 1,3,4,5,6-pentakisphosphate
-
 Sus scrofa
inositol 1,3,4-trisphosphate mixed-type inhibition Sus scrofa
Inositol 1,4,5-trisphosphate product inhibition kinetics Sus scrofa
inositol 3,4,5,6-tetrakisphosphate commercially available with 12% inositol 2,4,5,6-tetrakisphosphate, from turkey erythrocytes, marked inhibition, linear mixed-type inhibition Sus scrofa
additional information not inhibited by Mg2+, Ca2+, Li+, non-hydrolysable adenine, guanine nucleotides or deoxynucleotides Sus scrofa
UTP more effective inhibitor than GTP Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0004
-
 D-myo-Inositol 1,3,4,5-tetrakisphosphate
-
 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Sus scrofa
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
KCl activation Sus scrofa
additional information not activated by Ca2+ up to 1 mM or Mg2+ up to 30 mM Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
 gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O Sus scrofa enzyme may be regulated by the intracellular concentrations of inositol tris- and tetrakisphosphates D-myo-inositol 1,4,5-trisphosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Sus scrofa
-

Storage Stability

Storage Stability Organism
-80°C, several months, stable Sus scrofa
4°C, within weeks, loss of activity Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Sus scrofa D-myo-inositol 1,4,5-trisphosphate + phosphate
-
 ?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O enzyme may be regulated by the intracellular concentrations of inositol tris- and tetrakisphosphates Sus scrofa D-myo-inositol 1,4,5-trisphosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
additional information may be identical with EC 3.1.3.65 Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0005
-
 inositol 3,4,5,6-tetrakisphosphate pH 7.4, 37°C Sus scrofa
0.00175
-
 inositol 1,3,4-trisphosphate pH 7.4, 37°C Sus scrofa
0.002
-
 Inositol 1,4,5-trisphosphate pH 7.4, 37°C Sus scrofa