Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,3-bisphosphoglycerate | - |
Frog | |
2,3-bisphosphoglycerate | - |
Oryctolagus cuniculus | |
ATP | - |
Frog | |
ATP | - |
Oryctolagus cuniculus | |
CdCl2 | - |
Oryctolagus cuniculus | |
D-fructose 1,6-bisphosphate | - |
Oryctolagus cuniculus | |
D-fructose 2,6-bisphosphate | - |
Oryctolagus cuniculus | |
D-Glucose 1,6-bisphosphate | - |
Oryctolagus cuniculus | |
EDTA | - |
Oryctolagus cuniculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.016 | 0.019 | D-myo-inositol 1,4,5-trisphosphate | membrane bound enzyme, pH 7.2, 30°C | Oryctolagus cuniculus | |
0.024 | - |
D-myo-inositol 1,4,5-trisphosphate | soluble enzyme, pH 7.2, 30°C | Oryctolagus cuniculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | sarcotubular membrane, 60-65% of total activity | Oryctolagus cuniculus | 16020 | - |
soluble | 35-40% of total activity | Oryctolagus cuniculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-myo-inositol 1,4,5-trisphosphate + H2O | Oryctolagus cuniculus | involved in regulation of excitation-contraction coupling in skeletal muscle | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
D-myo-inositol 1,4,5-trisphosphate + H2O | Oryctolagus cuniculus | regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
D-myo-inositol 1,4,5-trisphosphate + H2O | Frog | regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Frog | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Oryctolagus cuniculus | - |
liver | - |
Oryctolagus cuniculus | - |
muscle | fast-twitch skeletal muscle | Oryctolagus cuniculus | - |
muscle | fast-twitch skeletal muscle | Frog | - |
muscle | smooth muscle of pulmonary artery | Oryctolagus cuniculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0006 | - |
muscle, pH 7.2, 30°C | Frog |
0.0014 | - |
muscle and liver, pH 7.2, 30°C | Oryctolagus cuniculus |
0.003 | - |
main pulmonary artery, pH 7.2, 30°C | Oryctolagus cuniculus |
0.0047 | - |
brain, pH 7.2, 30°C | Oryctolagus cuniculus |
0.02 | - |
Vmax, membrane fraction, pH 7.2, 30°C | Oryctolagus cuniculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-myo-inositol 1,4,5-trisphosphate + H2O | - |
Oryctolagus cuniculus | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
D-myo-inositol 1,4,5-trisphosphate + H2O | - |
Frog | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
D-myo-inositol 1,4,5-trisphosphate + H2O | involved in regulation of excitation-contraction coupling in skeletal muscle | Oryctolagus cuniculus | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
D-myo-inositol 1,4,5-trisphosphate + H2O | regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate | Oryctolagus cuniculus | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
D-myo-inositol 1,4,5-trisphosphate + H2O | regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate | Frog | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? |