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Literature summary for 3.1.3.56 extracted from

  • Connolly, T.M.; Bansal, V.S.; Bross, T.E.; Irvine, R.F.; Majerus, P.W.
    The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes (1987), J. Biol. Chem., 262, 2146-2149.
    View publication on PubMed
Search for more literature for 3.1.3.56

Inhibitors

Inhibitors Comment Organism Structure
Inositol 1,3,4,5-tetrakisphosphate competitive with D-myo-inositol 1,4,5-trisphosphate Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0009
-
 D-myo-Inositol 1,3,4,5-tetrakisphosphate pH 6.5, 37°C Homo sapiens
0.006
-
 D-myo-inositol 1,4,5-trisphosphate pH 6.5, 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O Homo sapiens
-
 D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O Homo sapiens regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein protein kinase C activates enzyme activity Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O very poor substrate Homo sapiens D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Homo sapiens D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Homo sapiens D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Homo sapiens D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0005
-
 Inositol 1,3,4,5-tetrakisphosphate
-
 Homo sapiens