Literature summary for 3.1.3.108 extracted from

Stubblefield, J.J.; Gao, P.; Kilaru, G.; Mukadam, B.; Terrien, J.; Green, C.B.
Temporal control of metabolic amplitude by nocturnin (2018), Cell Rep., 22, 1225-1235 .

Search for more literature for 3.1.3.108

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O35710	-	-

Expression

Organism	Comment	Expression
Mus musculus	expression depends on the circadian clock and nutrient status	down
Mus musculus	expression depends on the circadian clock and nutrient status	up

General Information

General Information	Comment	Organism
malfunction	mice lacking Nocturnin (Noct-/-) display significantly increased amplitudes of mRNA expression of hepatic genes encoding key metabolic enzymes regulating lipid and cholesterol synthesis, both over the daily circadian cycle and in response to fasting and refeeding. Noct-/- mice have increased plasma triglyceride throughout the night and increased amplitude of hepatic cholesterol levels. Posttranscriptional control by Nocturnin regulates the amplitude of these critical metabolic pathways, and loss of this activity results in increased metabolic flux and reduced obesity. Loss of Noct has a significant effect on epididymal white adipose tissue weight (eWAT), resulting in an overall reduced eWAT as a percentage of total body weight in KO mice	Mus musculus
physiological function	function for the circadian deadenylase nocturnin as a regulator of metabolic amplitude across the day/night cycle and in response to nutrient challenge. Posttranscriptional control by Nocturnin regulates the amplitude of lipid and cholesterol synthesis pathways	Mus musculus

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Release 2023.1 (January 2023)