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Information on EC 3.1.3.108 - nocturnin

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.108 nocturnin
IUBMB Comments
The mammalian mitochondrial enzyme is a rhythmically expressed protein that regulates metabolism under the control of circadian clock. It has a slight preference for NADPH over NADP+. The archaeal enzyme, identified in Methanocaldococcus jannaschii, is bifunctional acting as NAD+ kinase (EC 2.7.1.23) and NADP+ phosphatase with a slight preference for NADP+ over NADPH.
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Word Map
  • 3.1.3.108
  • hair
  • straight
  • catheter
  • deadenylase
  • woolly
  • chlorotic
  • curly
  • saccules
  • abaxial
  • hypotrichosis
  • tenckhoff
  • phytopathological
  • tppase
  • conidiophores
  • deadenylation
  • exit-site
  • downy
The expected taxonomic range for this enzyme is: Archaea, Eukaryota
Reaction Schemes
Synonyms
AF2372, Curled, MJ0109, MJ0917, NADP phosphatase, NADPase, NADPHase, NOCT, nocturnin, nocturnin (curled), more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
NADP+ + H2O = NAD+ + phosphate
show the reaction diagram
(2)
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NADPH + H2O = NADH + phosphate
show the reaction diagram
(1)
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