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Literature summary for 3.1.3.108 extracted from

  • Estrella, M.A.; Du, J.; Chen, L.; Rath, S.; Prangley, E.; Chitrakar, A.; Aoki, T.; Schedl, P.; Rabinowitz, J.; Korennykh, A.
    The metabolites NADP+ and NADPH are the targets of the circadian protein nocturnin (curled) (2019), Nat. Commun., 10, 2367 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.108

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method Homo sapiens

Protein Variants

Protein Variants Comment Organism
E140A active site mutant, catalytic activity is blocked Drosophila melanogaster

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ NOCT is inactive in the presence of Zn2+ and Ca2+ presumably due imperfect transition state formed due to a slight size mismatch of these ions Homo sapiens
Zn2+ NOCT is inactive in the presence of Zn2+ and Ca2+ presumably due imperfect transition state formed due to a slight size mismatch of these ions Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster A8JQX3
-
-
Homo sapiens Q9UK39
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
lung epithelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADP+ + H2O
-
 Homo sapiens NAD+ + phosphate
-
 ?
NADP+ + H2O
-
 Drosophila melanogaster NAD+ + phosphate
-
 ?
NADPH + H2O
-
 Homo sapiens NADH + phosphate
-
 ?
NADPH + H2O
-
 Drosophila melanogaster NADH + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Curled
-
 Drosophila melanogaster
NOCT
-
 Homo sapiens
nocturnin
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function rhythmically expressed protein that regulates metabolism under the control of circadian clock Homo sapiens
physiological function rhythmically expressed protein that regulates metabolism under the control of circadian clock Drosophila melanogaster