BRENDA - Enzyme Database
show all sequences of 3.1.1.8

Natural products and their derivatives as cholinesterase inhibitors in the treatment of neurodegenerative disorders: an update

Loizzo, M.R.; Tundis, R.; Menichini, F.; Menichini, F.; Curr. Med. Chem. 15, 1209-1228 (2008)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
(+)-7-deoxy-O6-buxafurandiene
isolated from Buxus hyrcana
Equus caballus
(+)-benzoylbuxidienine
isolated from Buxus hyrcana
Equus caballus
(+)-buxapapillinine
isolated from Buxus hyrcana
Equus caballus
(+)-buxaquamarine
isolated from Buxus hyrcana
Equus caballus
(+)-irehine
isolated from Buxus hyrcana
Equus caballus
(+)-O6-buxafurandiene
isolated from Buxus hyrcana
Equus caballus
(-)-10,10-dimethylhuperzine A
-
Equus caballus
(-)-3-O-acetyl-spectaline
isolated from flowers of Senna spectabilis
Equus caballus
(-)-galanthamine
isolated from Galanthus woronowii
Equus caballus
(-)-phenserine
-
Equus caballus
(-)-spectaline
isolated from flowers of Senna spectabilis
Equus caballus
(1alpha,3beta,22R)-stigmast-5-ene-1,3,22-triol
i.e. haloxysterol A, isolated from Haloxylon recurvum
Equus caballus
(1alpha,3beta,22R)-stigmasta-4,6-diene-1,3,22-triol
i.e. haloxysterol B, isolated from Haloxylon recurvum
Equus caballus
(1alpha,3beta,5alpha,6beta,22R)-stigmastane-1,3,5,6,22-pentol
i.e. haloxysterol D, isolated from Haloxylon recurvum
Equus caballus
(1S,2S,11bS)-4-[2-(acetyloxy)ethyl]-5-methyl-1,2,3,4,4a,5,6,11b-octahydro[1,3]dioxolo[4,5-j]phenanthridine-1,2-diyl diacetate
-
Equus caballus
(1S,2S,11bS)-4-[2-(acetyloxy)ethyl]-5-methyl-1,2,4a,5,6,11b-hexahydro[1,3]dioxolo[4,5-j]phenanthridine-1,2-diyl diacetate
-
Equus caballus
(22R)-22-hydroxystigmasta-4,9(11)-dien-3-one
i.e. haloxysterol , isolated from Haloxylon recurvum
Equus caballus
(24S)-ethylcholesta-7,9(11),22(E)-triene-3beta-ol
isolated from Haloxylon recurvum
Equus caballus
(2E)-1,3-diphenylprop-2-en-1-one
-
Equus caballus
(2E)-1-(5-chloro-2-hydroxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one
-
Equus caballus
(2E)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
Equus caballus
(2E)-3-(3,4-dimethoxyphenyl)-1-phenylprop-2-en-1-one
-
Equus caballus
(2E)-3-(3-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
Equus caballus
(2E)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
Equus caballus
(2E)-3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one
-
Equus caballus
(3,4-dimethoxyphenyl)(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methanol
-
Equus caballus
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,3-dimethylphenyl)carbamate
-
Equus caballus
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,4,6-trimethylphenyl)carbamate
-
Equus caballus
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,4-dimethylphenyl)carbamate
-
Equus caballus
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,5-dimethylphenyl)carbamate
-
Equus caballus
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,6-dimethylphenyl)carbamate
-
Equus caballus
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2-ethylphenyl)carbamate
-
Equus caballus
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3,4-dimethylphenyl)carbamate
-
Equus caballus
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3-methylphenyl)carbamate
-
Equus caballus
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-methylphenyl)carbamate
-
Equus caballus
(3beta,4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,28-dihydroxy-3-methoxy-1,26-dioxo-5,6:22,26-diepoxyergost-24-en-19-oic acid
isolated from Withania somnifera, noncompetitive inhibition
Equus caballus
(3beta,4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,28-dihydroxy-3-methoxy-5,6:22,26-diepoxyergost-24-ene-1,26-dione
isolated from Withania somnifera, noncompetitive inhibition
Equus caballus
(3beta,4beta,6beta,8xi,9xi,14xi,17xi,22R)-4,6,27-trihydroxy-3-methoxy-22,26-epoxyergost-24-ene-1,26-dione
isolated from Withania somnifera, noncompetitive inhibition
Equus caballus
(3R,4aS,9bS)-9-(chloromethyl)-9b-[2-[(ethoxycarbonyl)(methyl)amino]ethyl]-6-methoxy-3,4,4a,9b-tetrahydrodibenzo[b,d]furan-3-yl ethyl carbonate
-
Equus caballus
(4aS,6R,8aS)-3-methoxy-11-methyl-5,6,10,11,13,14-hexahydro-4aH,9H-[1]benzofuro[3a,3,2-gh][3,4]benzoxazonin-6-ol
-
Equus caballus
(4aS,6R,8aS)-3-methoxy-11-[8-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]octyl]-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol
-
Equus caballus
(4aS,6R,8aS)-3-[[12-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)dodecyl]oxy]-6-hydroxy-11-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
Equus caballus
(4aS,6R,8aS)-3-[[8-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]oxy]-6-hydroxy-11-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
Equus caballus
(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-[10-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]decyl]-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
Equus caballus
(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-[8-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]octyl]-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
Equus caballus
(4aS,6R,8aS)-6-hydroxy-3-methyl-11-(10-phenyldecyl)-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
Equus caballus
(4aS,6R,8aS)-6-hydroxy-3-methyl-11-(8-phenyloctyl)-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
Equus caballus
(4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,27-dihydroxy-5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione
isolated from Ajuga bracteosa, noncompetitive inhibition
Equus caballus
(5alpha,6alpha,7alpha,8xi,9xi,14xi,17xi,22R)-5-hydroxy-20-methyl-6,7:22,26-diepoxyergosta-2,24-diene-1,26-dione
isolated from Ajuga bracteosa, noncompetitive inhibition
Equus caballus
(6,7-dimethoxyisoquinolin-1-yl)(2-methoxyphenyl)methanol
-
Equus caballus
(6,7-dimethoxyisoquinolin-1-yl)(3,4-dimethoxyphenyl)methanol
-
Equus caballus
(6,7-dimethoxyisoquinolin-1-yl)(3,4-dimethoxyphenyl)methanone
-
Equus caballus
(8Z)-5,6-dihydro-8H-isoquino[1,2b]quinazolin-8-imine
-
Equus caballus
1,2,11,12-tetramethoxy-7-methyl-5,6-dihydro-4H,8H-pyrido[3,2,1-de]phenanthridinium
-
Equus caballus
1,2,3,10,11-pentamethoxy-7-(methoxycarbonyl)-5,6-dihydro-4H,8H-pyrido[3,2,1-de]phenanthridinium
-
Equus caballus
1,2,3,4,9,9a-hexahydroacridin-9-amine
-
Equus caballus
1,2-diacetyllycorine
-
Equus caballus
1,5,6-trimethyl-9-oxo-7H,9H-pyrano[3,4,5-ij]isoquinolin-1-ium
-
Equus caballus
1,8-cineole
isolated from Melaleuca atlernifolia
Equus caballus
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
-
Equus caballus
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methylisoquinolinium
-
Equus caballus
1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline
-
Equus caballus
1-epideacetylbowdensine
-
Equus caballus
1-methyl-1-[2-oxo-3-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)propyl]pyrrolidinium
-
Equus caballus
1-methyl-1-[3-oxo-4-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)butyl]pyrrolidinium
-
Equus caballus
1-methyl-1-[4-oxo-5-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)pentyl]pyrrolidinium
-
Equus caballus
1-methyl-4,5-dihydro[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-6-ium-2-olate
-
Equus caballus
12-n-butoxy-demethoxykesselringine
-
Equus caballus
13-methyl-5,8-dihydro-6H isoquino[1,2b]quinazolin-13-ium chloride
-
Equus caballus
13-methyl-5,8-dihydro-6H-isoquino[1,2b]quinazolin-13-ium chloride
-
Equus caballus
14-ethoxy-14-oxogalanthamine
-
Equus caballus
19,20-dihydroervahanin A
-
Equus caballus
19,20-dihydrotabernamine
-
Equus caballus
2-[[2-[(5aS,7R,9aS)-1-formyl-7-hydroxy-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl](methyl)amino]butanoic acid
-
Equus caballus
2-[[2-[(5aS,7R,9aS)-7-hydroxy-1-(hydroxymethyl)-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl](methyl)amino]butanoic acid
-
Equus caballus
24-ethyl-cholest-7-ene-3,5,6-triol
isolated from Haloxylon recurvum
Equus caballus
24-ethylcholest-6-ene-3,5-diol
isolated from Haloxylon recurvum
Equus caballus
2alpha,11alpha-dihydroxyfawcettiine
-
Equus caballus
2beta-hydroxyepipachysamine D
-
Equus caballus
3-(9-hydroxy-5,6-dimethyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-yl)propane-1,2-diol
-
Equus caballus
3-(9-methoxy-5,6-dimethyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-yl)propane-1,2-diol
-
Equus caballus
3-carene
50% inhibition at 2 mM
Equus caballus
3-hydroxy-2,2,6-trimethyl-3,4,5,6-tetrahydro-2H-pyrano[3,2c] quinoline 5-one
isolated from Skimmia laureola
Equus caballus
3-O-acetylhamayne
-
Equus caballus
4,5-diethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
4-cymene
isolated from Melaleuca atlernifolia
Equus caballus
4-ethenyl-5-ethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
4-ethenyl-5-hexyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
4-ethenyl-5-methyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
4-ethenyl-5-pentyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
4-ethenyl-5-propyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
4-ethyl-5-hexyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine hydrobromide
-
Equus caballus
4-ethyl-5-methyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
4-ethyl-5-pentyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
4-ethyl-5-propyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
4-ethyl-N-methyl-dihydrophenanthridine
-
Equus caballus
5,6-dimethoxy-9-prop-2-en-1-yl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-ol
-
Equus caballus
5,7,8,13-tetrahydroindolo [2',3':3,4]pyrido[2,1-b]quinazoline
-
Equus caballus
5,8-dihydro-6H isoquino[1,2b]quinazoline
-
Equus caballus
5-butyl-4-ethenyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
5-butyl-4-ethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
5-hydroxy-5,6-seco-dihydrolycorine
-
Equus caballus
5-hydroxy-5,6-secolycorine
-
Equus caballus
5alpha,8alpha-epidioxy-(24S)-ethylcholesta-6,9(11),22(E)-triene-3beta-ol
isolated from Haloxylon recurvum
Equus caballus
6-hydroxycrinamine
-
Equus caballus
6-O-demethylgalanthamine
-
Equus caballus
7-bromo-6-methyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-one
-
Equus caballus
8-alpha-ethoxyprecriwelline
-
Equus caballus
9,10-dimethoxy-1,2,3,12,15,16-hexadehydrogalanthan
-
Equus caballus
9-(2-oxo-3-pyrrolidin-1-ylpropyl)-7H-dibenzo[de,h]quinolin-7-one
-
Equus caballus
9-(2-oxo-4-pyrrolidin-1-ylbutyl)-7H-dibenzo[de,h]quinolin-7-one
-
Equus caballus
9-(2-oxo-5-pyrrolidin-1-ylpentyl)-7H-dibenzo[de,h]quinolin-7-one
-
Equus caballus
9-(4-[[2-(dimethylamino)ethyl]amino]-2-oxobutyl)-7H-dibenzo[de,h]quinolin-7-one
-
Equus caballus
9-[3-(dimethylamino)-2-oxopropyl]-7H-dibenzo[de,h]quinolin-7-one
-
Equus caballus
9-[4-(diethylamino)-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
Equus caballus
9-[4-(dimethylamino)-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
Equus caballus
9-[4-[(2-hydroxyethyl)amino]-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
Equus caballus
9-[5-(dimethylamino)-2-oxopentyl]-7H-dibenzo[de,h]quinolin-7-one
-
Equus caballus
acacetin
-
Equus caballus
alpha-terpinen
isolated from Melaleuca atlernifolia
Equus caballus
atricarpan A
-
Equus caballus
atricarpan B
-
Equus caballus
atricarpan C
-
Equus caballus
atricarpan D
-
Equus caballus
axillaridine A
-
Equus caballus
axillarine C
-
Equus caballus
axillarine F
-
Equus caballus
Berberine
-
Equus caballus
bis-Hup A
-
Equus caballus
bis-Hup B
-
Equus caballus
bisnorcymserine
-
Equus caballus
bulbocapnine
isolated from Corydalis cava
Equus caballus
buxabenzacinine
isolated from Buxus hyrcana
Equus caballus
buxandrine
isolated from Buxus hyrcana
Equus caballus
buxidin
isolated from Buxus hyrcana
Equus caballus
buxippine-K
isolated from Buxus hyrcana
Equus caballus
buxoviricine
isolated from Buxus hyrcana
Equus caballus
carinatumin A
-
Equus caballus
carvacrol
isolated from Thymus vulgaris essential oil
Equus caballus
cherylline
-
Equus caballus
corydine
specific for BChE
Equus caballus
crinamidine
-
Equus caballus
crinamine
-
Equus caballus
crinine
-
Equus caballus
cymserine
-
Equus caballus
dec-N-dimethylregeline
-
Equus caballus
dehydroevodiamine hydrochloride
isolated from Evodia rutaecarpa
Equus caballus
epibuphasine
-
Equus caballus
epivittatine
-
Equus caballus
ethyl [2-[(5aS,7R,9aS)-1-formyl-7-hydroxy-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl]methylcarbamate
-
Equus caballus
ethyl [2-[(5aS,7R,9aS)-7-hydroxy-1-(hydroxymethyl)-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl]methylcarbamate
-
Equus caballus
gamma-terpinen
isolated from Melaleuca atlernifolia
Equus caballus
haloxyline A
-
Equus caballus
haloxyline B
-
Equus caballus
hamayne
-
Equus caballus
homoproaporphine
-
Equus caballus
huperzine A
-
Equus caballus
huperzine B
-
Equus caballus
huperzine R
-
Equus caballus
huprine X
-
Equus caballus
huprine Y
-
Equus caballus
hyrcamine
isolated from Buxus hyrcana
Equus caballus
hyrcanone
isolated from Buxus hyrcana
Equus caballus
hyrcatrienine
isolated from Buxus hyrcana
Equus caballus
iolantamine iodomethylate
-
Equus caballus
isolariin A
isolated from Linaria reflexa
Equus caballus
isolariin B
isolated from Linaria reflexa
Equus caballus
isoquinolin-1-yl(2-methoxyphenyl)methanol
-
Equus caballus
Jatrorrhizine
-
Equus caballus
kesselridine
-
Equus caballus
kesselridine iodomethylate
-
Equus caballus
kesselringine
-
Equus caballus
lawsaritol
isolated from Haloxylon recurvum
Equus caballus
leufolin A
isolated from Leucas urticifolia
Equus caballus
leufolin B
isolated from Leucas urticifolia
Equus caballus
linalool
isolated from Thymus vulgaris essential oil
Equus caballus
linariin
-
Equus caballus
linarin
-
Equus caballus
luteidine
-
Equus caballus
luteidine iodomethylate
-
Equus caballus
luteinone
-
Equus caballus
lycoposerramine
-
Equus caballus
lycorine
-
Equus caballus
maritidine
-
Equus caballus
merenderin
-
Equus caballus
methyl isoplatydesmine
specific for BChE
Equus caballus
additional information
potency and mechanism of diverse enzyme inhibitors, corydaline and ribalinine, isolated from Skimmia laureola, are specific for acetylcholinesterase, overview
Equus caballus
N,N,N-trimethyl-2-oxo-3-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)propan-1-aminium
-
Equus caballus
N,N,N-trimethyl-3-oxo-4-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)butan-1-aminium
-
Equus caballus
N,N,N-trimethyl-4-oxo-5-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)pentan-1-aminium
-
Equus caballus
N-(2-phenylethyl)-N-[(12Z)-7,8,9,10-tetrahydroazepino [2,1b]quinazolin-12(6H)-ylidene]amine
-
Equus caballus
N-desmethyl-8alpha-ethoxypretazzettine
-
Equus caballus
N-desmethyl-8beta-ethoxypretazzettine
-
Equus caballus
N3-demethylsaracodine
-
Equus caballus
Nb-dimethylcycloxobuxoviricine
isolated from Buxus hyrcana
Equus caballus
O-acetyllycorine
-
Equus caballus
O-methylmaritidine
-
Equus caballus
oxazaphenalene lactone
-
Equus caballus
palmatine
-
Equus caballus
papyramine
-
Equus caballus
physostigmine
-
Equus caballus
powelline
-
Equus caballus
protoberberine
-
Equus caballus
regelamine
-
Equus caballus
regeline
-
Equus caballus
regeline iodomethylate
-
Equus caballus
rutaecaerpine
-
Equus caballus
saligcinnamide
-
Equus caballus
salignarine-C
isolated from Sarcococca saligna
Equus caballus
salignenamide A
-
Equus caballus
salignenamide D
-
Equus caballus
salignenamide E
-
Equus caballus
salignenamide F
-
Equus caballus
sarcorine
-
Equus caballus
sarcovagenine-C
isolated from Sarcococca saligna
Equus caballus
sarsalignenone
-
Equus caballus
sarsalignone
-
Equus caballus
slavin A
isolated from Salvia santolinifolia
Equus caballus
slavin B
isolated from Salvia santolinifolia
Equus caballus
stephaoxocanidine
-
Equus caballus
tacrine
-
Equus caballus
taspine
isolated from Thymus vulgaris essential oil
Equus caballus
tazettine
-
Equus caballus
terpinen-4-ol
isolated from Melaleuca atlernifolia
Equus caballus
thymohydroquinone
isolated from Thymus vulgaris essential oil
Equus caballus
Thymol
isolated from Thymus vulgaris essential oil
Equus caballus
thymoquinone
isolated from Thymus vulgaris essential oil
Equus caballus
tolserine
-
Equus caballus
undulatine
-
Equus caballus
vaganine A
-
Equus caballus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
extracellular
-
Equus caballus
-
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Homo sapiens
inhibition of BChE, along with the acetylcholinesterase, and restoration of acetylcholine is a therapeutic strategy in treatment of Alzheimer's disease and other forms of dementia
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Equus caballus
-
-
-
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
blood serum
-
Equus caballus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
inhibition of BChE, along with the acetylcholinesterase, and restoration of acetylcholine is a therapeutic strategy in treatment of Alzheimer's disease and other forms of dementia
691944
Homo sapiens
?
-
-
-
-
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
additional information
-
-
Equus caballus
additional information
0.0005
-
-
Equus caballus
5,7,8,13-tetrahydroindolo [2',3':3,4]pyrido[2,1-b]quinazoline
0.0011
-
-
Equus caballus
buxoviricine
0.00125
-
-
Equus caballus
salignarine-C
0.0015
-
-
Equus caballus
sarcovagenine-C
0.0016
-
-
Equus caballus
leufolin A
0.0036
-
-
Equus caballus
leufolin B
0.0044
-
-
Equus caballus
5,8-dihydro-6H isoquino[1,2b]quinazoline
0.0045
-
-
Equus caballus
(1alpha,3beta,22R)-stigmast-5-ene-1,3,22-triol
0.0125
-
-
Equus caballus
slavin A
0.0147
-
-
Equus caballus
haloxyline B
0.0186
-
-
Equus caballus
(-)-galanthamine
0.019
-
-
Equus caballus
haloxyline A
0.0195
-
-
Equus caballus
atricarpan C
0.02
-
-
Equus caballus
hyrcanone
0.0305
-
-
Equus caballus
atricarpan D
0.052
-
-
Equus caballus
corydine
0.0655
-
-
Equus caballus
atricarpan B
0.0655
-
-
Equus caballus
slavin B
0.083
-
-
Equus caballus
bulbocapnine
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
additional information
-
-
Equus caballus
additional information
0.0005
-
-
Equus caballus
5,7,8,13-tetrahydroindolo [2',3':3,4]pyrido[2,1-b]quinazoline
0.0011
-
-
Equus caballus
buxoviricine
0.00125
-
-
Equus caballus
salignarine-C
0.0015
-
-
Equus caballus
sarcovagenine-C
0.0016
-
-
Equus caballus
leufolin A
0.0036
-
-
Equus caballus
leufolin B
0.0044
-
-
Equus caballus
5,8-dihydro-6H isoquino[1,2b]quinazoline
0.0045
-
-
Equus caballus
(1alpha,3beta,22R)-stigmast-5-ene-1,3,22-triol
0.0125
-
-
Equus caballus
slavin A
0.0147
-
-
Equus caballus
haloxyline B
0.0186
-
-
Equus caballus
(-)-galanthamine
0.019
-
-
Equus caballus
haloxyline A
0.0195
-
-
Equus caballus
atricarpan C
0.02
-
-
Equus caballus
hyrcanone
0.0305
-
-
Equus caballus
atricarpan D
0.052
-
-
Equus caballus
corydine
0.0655
-
-
Equus caballus
atricarpan B
0.0655
-
-
Equus caballus
slavin B
0.083
-
-
Equus caballus
bulbocapnine
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(+)-7-deoxy-O6-buxafurandiene
isolated from Buxus hyrcana
Equus caballus
(+)-benzoylbuxidienine
isolated from Buxus hyrcana
Equus caballus
(+)-buxapapillinine
isolated from Buxus hyrcana
Equus caballus
(+)-buxaquamarine
isolated from Buxus hyrcana
Equus caballus
(+)-irehine
isolated from Buxus hyrcana
Equus caballus
(+)-O6-buxafurandiene
isolated from Buxus hyrcana
Equus caballus
(-)-10,10-dimethylhuperzine A
-
Equus caballus
(-)-3-O-acetyl-spectaline
isolated from flowers of Senna spectabilis
Equus caballus
(-)-galanthamine
isolated from Galanthus woronowii
Equus caballus
(-)-phenserine
-
Equus caballus
(-)-spectaline
isolated from flowers of Senna spectabilis
Equus caballus
(1alpha,3beta,22R)-stigmast-5-ene-1,3,22-triol
i.e. haloxysterol A, isolated from Haloxylon recurvum
Equus caballus
(1alpha,3beta,22R)-stigmasta-4,6-diene-1,3,22-triol
i.e. haloxysterol B, isolated from Haloxylon recurvum
Equus caballus
(1alpha,3beta,5alpha,6beta,22R)-stigmastane-1,3,5,6,22-pentol
i.e. haloxysterol D, isolated from Haloxylon recurvum
Equus caballus
(1S,2S,11bS)-4-[2-(acetyloxy)ethyl]-5-methyl-1,2,3,4,4a,5,6,11b-octahydro[1,3]dioxolo[4,5-j]phenanthridine-1,2-diyl diacetate
-
Equus caballus
(1S,2S,11bS)-4-[2-(acetyloxy)ethyl]-5-methyl-1,2,4a,5,6,11b-hexahydro[1,3]dioxolo[4,5-j]phenanthridine-1,2-diyl diacetate
-
Equus caballus
(22R)-22-hydroxystigmasta-4,9(11)-dien-3-one
i.e. haloxysterol , isolated from Haloxylon recurvum
Equus caballus
(24S)-ethylcholesta-7,9(11),22(E)-triene-3beta-ol
isolated from Haloxylon recurvum
Equus caballus
(2E)-1,3-diphenylprop-2-en-1-one
-
Equus caballus
(2E)-1-(5-chloro-2-hydroxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one
-
Equus caballus
(2E)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
Equus caballus
(2E)-3-(3,4-dimethoxyphenyl)-1-phenylprop-2-en-1-one
-
Equus caballus
(2E)-3-(3-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
Equus caballus
(2E)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
Equus caballus
(2E)-3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one
-
Equus caballus
(3,4-dimethoxyphenyl)(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methanol
-
Equus caballus
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,3-dimethylphenyl)carbamate
-
Equus caballus
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,4,6-trimethylphenyl)carbamate
-
Equus caballus
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,4-dimethylphenyl)carbamate
-
Equus caballus
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,5-dimethylphenyl)carbamate
-
Equus caballus
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,6-dimethylphenyl)carbamate
-
Equus caballus
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2-ethylphenyl)carbamate
-
Equus caballus
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3,4-dimethylphenyl)carbamate
-
Equus caballus
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3-methylphenyl)carbamate
-
Equus caballus
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-methylphenyl)carbamate
-
Equus caballus
(3beta,4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,28-dihydroxy-3-methoxy-1,26-dioxo-5,6:22,26-diepoxyergost-24-en-19-oic acid
isolated from Withania somnifera, noncompetitive inhibition
Equus caballus
(3beta,4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,28-dihydroxy-3-methoxy-5,6:22,26-diepoxyergost-24-ene-1,26-dione
isolated from Withania somnifera, noncompetitive inhibition
Equus caballus
(3beta,4beta,6beta,8xi,9xi,14xi,17xi,22R)-4,6,27-trihydroxy-3-methoxy-22,26-epoxyergost-24-ene-1,26-dione
isolated from Withania somnifera, noncompetitive inhibition
Equus caballus
(3R,4aS,9bS)-9-(chloromethyl)-9b-[2-[(ethoxycarbonyl)(methyl)amino]ethyl]-6-methoxy-3,4,4a,9b-tetrahydrodibenzo[b,d]furan-3-yl ethyl carbonate
-
Equus caballus
(4aS,6R,8aS)-3-methoxy-11-methyl-5,6,10,11,13,14-hexahydro-4aH,9H-[1]benzofuro[3a,3,2-gh][3,4]benzoxazonin-6-ol
-
Equus caballus
(4aS,6R,8aS)-3-methoxy-11-[8-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]octyl]-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol
-
Equus caballus
(4aS,6R,8aS)-3-[[12-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)dodecyl]oxy]-6-hydroxy-11-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
Equus caballus
(4aS,6R,8aS)-3-[[8-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]oxy]-6-hydroxy-11-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
Equus caballus
(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-[10-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]decyl]-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
Equus caballus
(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-[8-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]octyl]-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
Equus caballus
(4aS,6R,8aS)-6-hydroxy-3-methyl-11-(10-phenyldecyl)-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
Equus caballus
(4aS,6R,8aS)-6-hydroxy-3-methyl-11-(8-phenyloctyl)-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
Equus caballus
(4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,27-dihydroxy-5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione
isolated from Ajuga bracteosa, noncompetitive inhibition
Equus caballus
(5alpha,6alpha,7alpha,8xi,9xi,14xi,17xi,22R)-5-hydroxy-20-methyl-6,7:22,26-diepoxyergosta-2,24-diene-1,26-dione
isolated from Ajuga bracteosa, noncompetitive inhibition
Equus caballus
(6,7-dimethoxyisoquinolin-1-yl)(2-methoxyphenyl)methanol
-
Equus caballus
(6,7-dimethoxyisoquinolin-1-yl)(3,4-dimethoxyphenyl)methanol
-
Equus caballus
(6,7-dimethoxyisoquinolin-1-yl)(3,4-dimethoxyphenyl)methanone
-
Equus caballus
(8Z)-5,6-dihydro-8H-isoquino[1,2b]quinazolin-8-imine
-
Equus caballus
1,2,11,12-tetramethoxy-7-methyl-5,6-dihydro-4H,8H-pyrido[3,2,1-de]phenanthridinium
-
Equus caballus
1,2,3,10,11-pentamethoxy-7-(methoxycarbonyl)-5,6-dihydro-4H,8H-pyrido[3,2,1-de]phenanthridinium
-
Equus caballus
1,2,3,4,9,9a-hexahydroacridin-9-amine
-
Equus caballus
1,2-diacetyllycorine
-
Equus caballus
1,5,6-trimethyl-9-oxo-7H,9H-pyrano[3,4,5-ij]isoquinolin-1-ium
-
Equus caballus
1,8-cineole
isolated from Melaleuca atlernifolia
Equus caballus
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
-
Equus caballus
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methylisoquinolinium
-
Equus caballus
1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline
-
Equus caballus
1-epideacetylbowdensine
-
Equus caballus
1-methyl-1-[2-oxo-3-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)propyl]pyrrolidinium
-
Equus caballus
1-methyl-1-[3-oxo-4-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)butyl]pyrrolidinium
-
Equus caballus
1-methyl-1-[4-oxo-5-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)pentyl]pyrrolidinium
-
Equus caballus
1-methyl-4,5-dihydro[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-6-ium-2-olate
-
Equus caballus
12-n-butoxy-demethoxykesselringine
-
Equus caballus
13-methyl-5,8-dihydro-6H isoquino[1,2b]quinazolin-13-ium chloride
-
Equus caballus
13-methyl-5,8-dihydro-6H-isoquino[1,2b]quinazolin-13-ium chloride
-
Equus caballus
14-ethoxy-14-oxogalanthamine
-
Equus caballus
19,20-dihydroervahanin A
-
Equus caballus
19,20-dihydrotabernamine
-
Equus caballus
2-[[2-[(5aS,7R,9aS)-1-formyl-7-hydroxy-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl](methyl)amino]butanoic acid
-
Equus caballus
2-[[2-[(5aS,7R,9aS)-7-hydroxy-1-(hydroxymethyl)-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl](methyl)amino]butanoic acid
-
Equus caballus
24-ethyl-cholest-7-ene-3,5,6-triol
isolated from Haloxylon recurvum
Equus caballus
24-ethylcholest-6-ene-3,5-diol
isolated from Haloxylon recurvum
Equus caballus
2alpha,11alpha-dihydroxyfawcettiine
-
Equus caballus
2beta-hydroxyepipachysamine D
-
Equus caballus
3-(9-hydroxy-5,6-dimethyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-yl)propane-1,2-diol
-
Equus caballus
3-(9-methoxy-5,6-dimethyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-yl)propane-1,2-diol
-
Equus caballus
3-carene
50% inhibition at 2 mM
Equus caballus
3-hydroxy-2,2,6-trimethyl-3,4,5,6-tetrahydro-2H-pyrano[3,2c] quinoline 5-one
isolated from Skimmia laureola
Equus caballus
3-O-acetylhamayne
-
Equus caballus
4,5-diethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
4-cymene
isolated from Melaleuca atlernifolia
Equus caballus
4-ethenyl-5-ethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
4-ethenyl-5-hexyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
4-ethenyl-5-methyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
4-ethenyl-5-pentyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
4-ethenyl-5-propyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
4-ethyl-5-hexyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine hydrobromide
-
Equus caballus
4-ethyl-5-methyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
4-ethyl-5-pentyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
4-ethyl-5-propyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
4-ethyl-N-methyl-dihydrophenanthridine
-
Equus caballus
5,6-dimethoxy-9-prop-2-en-1-yl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-ol
-
Equus caballus
5,7,8,13-tetrahydroindolo [2',3':3,4]pyrido[2,1-b]quinazoline
-
Equus caballus
5,8-dihydro-6H isoquino[1,2b]quinazoline
-
Equus caballus
5-butyl-4-ethenyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
5-butyl-4-ethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
Equus caballus
5-hydroxy-5,6-seco-dihydrolycorine
-
Equus caballus
5-hydroxy-5,6-secolycorine
-
Equus caballus
5alpha,8alpha-epidioxy-(24S)-ethylcholesta-6,9(11),22(E)-triene-3beta-ol
isolated from Haloxylon recurvum
Equus caballus
6-hydroxycrinamine
-
Equus caballus
6-O-demethylgalanthamine
-
Equus caballus
7-bromo-6-methyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-one
-
Equus caballus
8-alpha-ethoxyprecriwelline
-
Equus caballus
9,10-dimethoxy-1,2,3,12,15,16-hexadehydrogalanthan
-
Equus caballus
9-(2-oxo-3-pyrrolidin-1-ylpropyl)-7H-dibenzo[de,h]quinolin-7-one
-
Equus caballus
9-(2-oxo-4-pyrrolidin-1-ylbutyl)-7H-dibenzo[de,h]quinolin-7-one
-
Equus caballus
9-(2-oxo-5-pyrrolidin-1-ylpentyl)-7H-dibenzo[de,h]quinolin-7-one
-
Equus caballus
9-(4-[[2-(dimethylamino)ethyl]amino]-2-oxobutyl)-7H-dibenzo[de,h]quinolin-7-one
-
Equus caballus
9-[3-(dimethylamino)-2-oxopropyl]-7H-dibenzo[de,h]quinolin-7-one
-
Equus caballus
9-[4-(diethylamino)-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
Equus caballus
9-[4-(dimethylamino)-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
Equus caballus
9-[4-[(2-hydroxyethyl)amino]-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
Equus caballus
9-[5-(dimethylamino)-2-oxopentyl]-7H-dibenzo[de,h]quinolin-7-one
-
Equus caballus
acacetin
-
Equus caballus
alpha-terpinen
isolated from Melaleuca atlernifolia
Equus caballus
atricarpan A
-
Equus caballus
atricarpan B
-
Equus caballus
atricarpan C
-
Equus caballus
atricarpan D
-
Equus caballus
axillaridine A
-
Equus caballus
axillarine C
-
Equus caballus
axillarine F
-
Equus caballus
Berberine
-
Equus caballus
bis-Hup A
-
Equus caballus
bis-Hup B
-
Equus caballus
bisnorcymserine
-
Equus caballus
bulbocapnine
isolated from Corydalis cava
Equus caballus
buxabenzacinine
isolated from Buxus hyrcana
Equus caballus
buxandrine
isolated from Buxus hyrcana
Equus caballus
buxidin
isolated from Buxus hyrcana
Equus caballus
buxippine-K
isolated from Buxus hyrcana
Equus caballus
buxoviricine
isolated from Buxus hyrcana
Equus caballus
carinatumin A
-
Equus caballus
carvacrol
isolated from Thymus vulgaris essential oil
Equus caballus
cherylline
-
Equus caballus
corydine
specific for BChE
Equus caballus
crinamidine
-
Equus caballus
crinamine
-
Equus caballus
crinine
-
Equus caballus
cymserine
-
Equus caballus
dec-N-dimethylregeline
-
Equus caballus
dehydroevodiamine hydrochloride
isolated from Evodia rutaecarpa
Equus caballus
epibuphasine
-
Equus caballus
epivittatine
-
Equus caballus
ethyl [2-[(5aS,7R,9aS)-1-formyl-7-hydroxy-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl]methylcarbamate
-
Equus caballus
ethyl [2-[(5aS,7R,9aS)-7-hydroxy-1-(hydroxymethyl)-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl]methylcarbamate
-
Equus caballus
gamma-terpinen
isolated from Melaleuca atlernifolia
Equus caballus
haloxyline A
-
Equus caballus
haloxyline B
-
Equus caballus
hamayne
-
Equus caballus
homoproaporphine
-
Equus caballus
huperzine A
-
Equus caballus
huperzine B
-
Equus caballus
huperzine R
-
Equus caballus
huprine X
-
Equus caballus
huprine Y
-
Equus caballus
hyrcamine
isolated from Buxus hyrcana
Equus caballus
hyrcanone
isolated from Buxus hyrcana
Equus caballus
hyrcatrienine
isolated from Buxus hyrcana
Equus caballus
iolantamine iodomethylate
-
Equus caballus
isolariin A
isolated from Linaria reflexa
Equus caballus
isolariin B
isolated from Linaria reflexa
Equus caballus
isoquinolin-1-yl(2-methoxyphenyl)methanol
-
Equus caballus
Jatrorrhizine
-
Equus caballus
kesselridine
-
Equus caballus
kesselridine iodomethylate
-
Equus caballus
kesselringine
-
Equus caballus
lawsaritol
isolated from Haloxylon recurvum
Equus caballus
leufolin A
isolated from Leucas urticifolia
Equus caballus
leufolin B
isolated from Leucas urticifolia
Equus caballus
linalool
isolated from Thymus vulgaris essential oil
Equus caballus
linariin
-
Equus caballus
linarin
-
Equus caballus
luteidine
-
Equus caballus
luteidine iodomethylate
-
Equus caballus
luteinone
-
Equus caballus
lycoposerramine
-
Equus caballus
lycorine
-
Equus caballus
maritidine
-
Equus caballus
merenderin
-
Equus caballus
methyl isoplatydesmine
specific for BChE
Equus caballus
additional information
potency and mechanism of diverse enzyme inhibitors, corydaline and ribalinine, isolated from Skimmia laureola, are specific for acetylcholinesterase, overview
Equus caballus
N,N,N-trimethyl-2-oxo-3-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)propan-1-aminium
-
Equus caballus
N,N,N-trimethyl-3-oxo-4-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)butan-1-aminium
-
Equus caballus
N,N,N-trimethyl-4-oxo-5-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)pentan-1-aminium
-
Equus caballus
N-(2-phenylethyl)-N-[(12Z)-7,8,9,10-tetrahydroazepino [2,1b]quinazolin-12(6H)-ylidene]amine
-
Equus caballus
N-desmethyl-8alpha-ethoxypretazzettine
-
Equus caballus
N-desmethyl-8beta-ethoxypretazzettine
-
Equus caballus
N3-demethylsaracodine
-
Equus caballus
Nb-dimethylcycloxobuxoviricine
isolated from Buxus hyrcana
Equus caballus
O-acetyllycorine
-
Equus caballus
O-methylmaritidine
-
Equus caballus
oxazaphenalene lactone
-
Equus caballus
palmatine
-
Equus caballus
papyramine
-
Equus caballus
physostigmine
-
Equus caballus
powelline
-
Equus caballus
protoberberine
-
Equus caballus
regelamine
-
Equus caballus
regeline
-
Equus caballus
regeline iodomethylate
-
Equus caballus
rutaecaerpine
-
Equus caballus
saligcinnamide
-
Equus caballus
salignarine-C
isolated from Sarcococca saligna
Equus caballus
salignenamide A
-
Equus caballus
salignenamide D
-
Equus caballus
salignenamide E
-
Equus caballus
salignenamide F
-
Equus caballus
sarcorine
-
Equus caballus
sarcovagenine-C
isolated from Sarcococca saligna
Equus caballus
sarsalignenone
-
Equus caballus
sarsalignone
-
Equus caballus
slavin A
isolated from Salvia santolinifolia
Equus caballus
slavin B
isolated from Salvia santolinifolia
Equus caballus
stephaoxocanidine
-
Equus caballus
tacrine
-
Equus caballus
taspine
isolated from Thymus vulgaris essential oil
Equus caballus
tazettine
-
Equus caballus
terpinen-4-ol
isolated from Melaleuca atlernifolia
Equus caballus
thymohydroquinone
isolated from Thymus vulgaris essential oil
Equus caballus
Thymol
isolated from Thymus vulgaris essential oil
Equus caballus
thymoquinone
isolated from Thymus vulgaris essential oil
Equus caballus
tolserine
-
Equus caballus
undulatine
-
Equus caballus
vaganine A
-
Equus caballus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
extracellular
-
Equus caballus
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Homo sapiens
inhibition of BChE, along with the acetylcholinesterase, and restoration of acetylcholine is a therapeutic strategy in treatment of Alzheimer's disease and other forms of dementia
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
blood serum
-
Equus caballus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
inhibition of BChE, along with the acetylcholinesterase, and restoration of acetylcholine is a therapeutic strategy in treatment of Alzheimer's disease and other forms of dementia
691944
Homo sapiens
?
-
-
-
-
Other publictions for EC 3.1.1.8
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
749836
Alkanaimsh
-
Purification and site-specifi ...
Homo sapiens
Biochem. Eng. J.
142
58-67
2019
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
1
1
-
-
1
1
-
2
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1
-
-
-
1
-
-
-
-
-
-
-
-
1
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-
-
-
-
-
-
-
-
-
-
1
-
-
1
1
-
1
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
749746
Saxena
Characterization of butyrylch ...
Homo sapiens, Sus scrofa
Arch. Biochem. Biophys.
652
38-49
2018
5
-
-
-
-
-
24
6
-
-
2
2
-
5
-
-
2
-
-
3
1
-
9
1
2
-
-
5
2
-
-
-
16
-
-
5
-
-
-
-
-
-
-
24
16
6
-
-
2
2
-
-
-
2
-
3
1
-
9
1
2
-
-
5
2
-
-
-
-
2
2
-
5
5
749761
Ali
Kinetics and molecular dockin ...
Equus caballus
Arch. Pharm. Res.
41
753-764
2018
-
-
-
-
-
-
8
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
-
7
-
7
-
-
-
-
-
-
-
7
8
7
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
749766
Hagstrom
Planarian cholinesterase mole ...
Dugesia japonica
Arch. Toxicol.
92
1161-1176
2018
-
-
1
-
1
-
3
-
-
-
-
1
-
5
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
3
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
750130
Corbin
Purification, characterizatio ...
Oryza sativa
Biotechnol. Bioeng.
115
1301-1310
2018
-
1
-
-
1
-
6
1
-
-
-
-
-
3
-
1
1
-
-
2
-
-
1
-
1
-
1
1
1
1
-
-
-
-
-
-
1
-
-
-
1
-
-
6
-
1
-
-
-
-
-
-
1
1
-
2
-
-
1
-
1
-
1
1
1
1
-
-
-
1
1
-
-
-
750291
Kim
Kinetic characterization of c ...
Homo sapiens
Chem. Biol. Interact.
293
107-114
2018
-
-
1
-
-
-
-
3
-
-
-
1
-
1
-
-
1
-
-
-
-
-
5
-
1
-
-
3
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
3
-
-
-
1
-
-
-
1
-
-
-
-
5
-
1
-
-
3
1
-
-
-
-
1
1
-
3
3
750359
Begum
In-vitro evaluation and in-si ...
Equus caballus
Comput. Biol. Chem.
74
212-217
2018
-
-
-
-
-
-
6
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
4
6
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
750379
Altaf
Ferrocene-based anilides synt ...
Homo sapiens
Dalton Trans.
47
11769-11781
2018
-
-
-
-
-
-
28
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
3
-
1
-
-
-
1
-
-
-
1
-
27
-
-
-
-
-
-
-
27
28
1
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
750796
Larik
New cholinesterase inhibitors ...
Homo sapiens
Int. J. Biol. Macromol.
116
144-150
2018
-
-
-
-
-
-
17
-
-
-
-
1
-
1
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-
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-
-
-
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1
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-
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-
-
-
-
-
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-
-
16
-
-
-
-
-
-
-
16
17
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
751194
Lockridge
Purification of recombinant h ...
Homo sapiens
J. Chromatogr. B
1102-1103
109-115
2018
-
-
1
-
1
-
1
-
1
-
-
1
-
3
-
1
1
-
-
2
1
-
2
1
1
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
1
-
1
1
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-
1
-
-
1
-
-
1
1
-
2
1
-
2
1
1
-
-
-
1
-
-
-
-
2
2
-
-
-
751199
Lee
Comparison of efficiency of p ...
Homo sapiens
J. Chromatogr. Sci.
56
248-253
2018
-
1
-
-
-
-
1
-
1
-
-
1
-
2
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1
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-
2
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1
1
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1
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1
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1
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1
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1
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2
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1
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
751208
Ferre
Reference values for acetyl a ...
Bos taurus
J. Environ. Sci. Health B
53
191-198
2018
-
-
-
-
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-
2
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2
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4
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1
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2
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1
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1
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2
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2
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1
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2
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1
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1
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-
-
1
1
-
-
-
751209
Terali
Evaluation of the inhibitory ...
Equus caballus
J. Environ. Sci. Health B
8
1-6
2018
-
-
-
-
-
-
3
1
1
-
-
1
-
3
-
-
-
-
-
3
-
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2
-
1
-
-
-
1
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-
-
2
-
1
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-
-
-
-
-
-
1
3
2
1
1
-
-
1
-
-
-
-
-
3
-
-
2
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
751284
Zorbaz
Pyridinium oximes with ortho- ...
Homo sapiens
J. Med. Chem.
61
10753-10766
2018
-
-
-
-
-
-
17
-
-
-
-
1
-
1
-
-
-
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1
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2
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1
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1
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-
8
-
-
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-
-
-
-
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-
17
8
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1
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1
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2
-
1
-
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1
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-
-
-
-
-
-
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-
751285
Kosak
The magic of crystal structur ...
Homo sapiens, Rattus norvegicus
J. Med. Chem.
61
119-139
2018
-
1
-
1
-
-
16
-
-
-
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2
-
4
-
-
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-
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8
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4
-
2
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2
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2
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14
-
1
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1
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-
14
16
2
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2
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8
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4
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
751817
Elsebai
-
Amberboin and lipidiol X-ray ...
Homo sapiens
Phytochem. Lett.
27
44-48
2018
-
-
-
-
-
-
2
-
-
-
-
1
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1
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-
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-
1
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1
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-
-
-
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-
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-
-
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1
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-
-
-
-
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1
2
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-
-
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1
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-
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
752242
Petrov
Specific inhibition of acetyl ...
Homo sapiens
Sci. Rep.
8
304
2018
-
-
-
-
-
-
4
-
-
-
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1
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3
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-
-
-
-
2
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2
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-
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-
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1
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-
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4
1
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1
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-
-
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2
-
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2
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-
-
-
-
-
-
-
-
-
2
2
-
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-
749765
Hagstrom
Planarian cholinesterase in v ...
Dugesia japonica
Arch. Toxicol.
91
2837-2847
2017
-
-
-
-
-
-
16
-
-
-
-
1
-
6
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
1
-
4
-
-
-
-
-
-
-
4
16
1
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-
-
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1
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-
-
-
-
-
-
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1
-
1
-
-
-
1
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-
-
-
2
2
-
-
-
750019
Sultana
Synthesis, crystal structure ...
Equus caballus
Bioorg. Chem.
72
256-267
2017
-
-
-
-
-
-
45
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
35
-
-
-
-
-
-
-
35
45
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
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-
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750040
Liu
Design, synthesis and biologi ...
Equus caballus
Bioorg. Med. Chem.
25
2387-2398
2017
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18
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1
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2
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-
1
-
1
-
-
-
1
-
-
-
-
-
17
-
-
-
-
-
-
-
17
18
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
-
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1
1
-
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750041
Mohammed
Stereospecific cholinesterase ...
Equus caballus
Bioorg. Med. Chem.
25
3053-3058
2017
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13
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3
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-
3
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-
1
-
1
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
13
2
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
1
-
-
-
1
-
-
-
-
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-
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750042
Nakayama
Synthesis, biochemical evalua ...
Equus caballus
Bioorg. Med. Chem.
25
3171-3181
2017
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-
-
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25
-
-
-
-
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-
1
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
-
13
-
-
-
-
-
-
-
-
-
-
25
13
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
-
-
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-
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750289
Dafferner
Characterization of butyrylch ...
Bos taurus
Chem. Biol. Interact.
266
17-27
2017
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1
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8
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2
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-
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1
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3
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-
1
-
-
3
-
-
4
2
1
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
8
-
-
2
1
-
-
-
-
1
-
-
-
1
-
3
-
-
4
2
1
-
-
-
1
-
-
-
-
1
1
-
-
-
750298
Yang
Discovery of a butyrylcholine ...
Homo sapiens
Chem. Commun. (Camb.)
53
3952-3955
2017
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-
-
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2
3
1
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-
1
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1
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-
-
-
-
1
-
-
4
-
1
-
-
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
1
3
1
-
-
1
-
-
-
-
-
1
-
-
4
-
1
-
-
2
1
-
-
-
-
2
2
-
2
2
750357
Mennillo
Suitability of cholinesterase ...
Diopatra neapolitana
Comp. Biochem. Physiol. C
191
152-159
2017
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7
3
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1
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-
3
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-
-
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-
1
2
-
2
1
1
-
-
-
1
-
-
-
-
-
5
-
-
-
-
-
-
-
5
7
-
3
-
-
1
-
-
-
-
-
-
1
2
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
750566
Albendin
Characterization and in vitro ...
Sparus aurata
Fish Physiol. Biochem.
43
455-464
2017
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-
-
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5
3
-
-
-
1
-
1
-
-
-
-
-
4
-
-
5
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
3
-
-
-
1
-
-
-
-
-
4
-
-
5
-
1
-
-
-
1
-
-
-
-
-
-
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-
750901
Macdonald
Quantification of butyrylchol ...
Homo sapiens
J. Alzheimers Dis.
58
491-505
2017
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1
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1
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1
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-
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2
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
1
-
-
-
-
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751217
Rozengart
-
Substrate-inhibitor specifici ...
Berryteuthis magister, Todarodes pacificus
J. Evol. Biochem. Physiol.
53
111-122
2017
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42
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2
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2
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4
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8
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2
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-
2
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-
-
2
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-
-
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-
-
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42
2
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-
-
-
2
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-
-
-
-
4
-
-
8
-
2
-
-
-
2
-
-
-
-
2
2
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-
751379
Xiao
A new method to characterize ...
Canis lupus familiaris, Homo sapiens
J. Pharm. Biomed. Anal.
144
175-182
2017
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-
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14
2
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2
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4
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-
-
-
-
4
-
-
4
-
2
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
-
14
2
2
-
-
-
2
-
-
-
-
-
4
-
-
4
-
2
-
-
-
2
-
-
-
-
-
-
-
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-
751624
Ali
Kinetics and molecular dockin ...
Equus caballus
Molecules
22
1604-1616
2017
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10
-
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1
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2
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-
2
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-
1
-
1
-
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
4
10
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
-
-
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-
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743326
Meirer
Design, synthesis and cellula ...
Homo sapiens
Molecules
22
0000
2016
-
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1
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8
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1
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-
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-
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-
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-
5
-
-
-
-
-
-
1
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8
5
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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1
1
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749760
Bhakta
Kinetics and molecular dockin ...
Homo sapiens
Arch. Pharm. Res.
39
794-805
2016
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5
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1
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1
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1
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3
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4
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4
5
3
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-
1
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1
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750017
Fogle
An investigation into the but ...
Equus caballus
Bioorg. Chem.
65
57-60
2016
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1
1
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1
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2
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5
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1
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1
-
1
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1
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2
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5
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1
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1
1
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750216
Rodriguez-Fuentes
Cholinesterases in Gambusia y ...
Gambusia yucatana
Bull. Environ. Contam. Toxicol.
97
776-780
2016
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1
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1
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4
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4
2
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3
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1
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1
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2
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1
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Pope
In vitro characterization of ...
Homo sapiens
Biochem. Pharmacol.
98
531-539
2015
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1
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1
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2
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1
2
1
2
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1
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-
1
1
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-
1
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-
2
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-
-
1
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-
1
-
2
-
1
2
1
2
-
-
-
1
-
-
-
-
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-
-
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750028
Wieckowska
Synthesis of new N-benzylpipe ...
Equus caballus
Bioorg. Med. Chem.
23
2445-2457
2015
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1
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31
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2
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1
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1
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1
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27
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1
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27
31
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2
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1
-
1
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1
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728949
Dingova
Optimal detection of cholinest ...
Homo sapiens, Mus musculus
Anal. Biochem.
462
67-75
2014
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2
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2
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2
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4
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4
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-
-
-
-
-
-
-
-
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-
-
-
-
2
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-
-
2
-
-
-
-
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4
-
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4
-
-
-
-
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729571
Correa-Basurto
QSAR, docking, dynamic simulat ...
Homo sapiens
Chem. Biol. Interact.
209
1-13
2014
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8
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1
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1
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-
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-
-
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-
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-
-
-
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8
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-
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-
1
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-
-
-
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-
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-
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730434
Vinsova
Diethyl 2-(phenylcarbamoyl)phe ...
Equus caballus
Molecules
19
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2014
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29
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8
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29
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29
29
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1
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729092
Perez
Characterization of cholineste ...
Chironomus riparius
Aquat. Toxicol.
144-145
296-302
2013
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1
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1
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2
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1
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1
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-
2
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729162
Nachon
Crystal structures of human ch ...
Homo sapiens
Biochem. J.
453
393-399
2013
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1
-
1
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1
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-
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729366
Yoon
Synthesis, characterization, a ...
Homo sapiens
Bioorg. Chem.
49
33-39
2013
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7
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1
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7
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7
7
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1
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729566
Trovaslet
Relation between dynamics, act ...
Homo sapiens
Chem. Biol. Interact.
203
14-18
2013
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1
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1
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1
1
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1
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1
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1
1
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729569
Stojan
The significance of low substr ...
Equus caballus
Chem. Biol. Interact.
203
44-50
2013
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2
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1
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2
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Wamser
Effect of hypoxanthine, antiox ...
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J. Neural Transm.
120
1359-1367
2013
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2
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1
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12
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2
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1
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1
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729273
Masson
Time-dependent kinetic complex ...
Homo sapiens
Biochemistry
77
1147-1161
2012
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4
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1
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2
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2
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1
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4
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730567
Torres
Structural insights into choli ...
Equus caballus
Phytochemistry
81
24-30
2012
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7
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3
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6
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6
7
3
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1
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1
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714094
Nachon
X-ray crystallographic snapsho ...
Homo sapiens
Biochem. J.
434
73-82
2011
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1
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3
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1
-
1
1
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1
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714121
Chuiko
-
Substrate-inhibitory analysis ...
Lumbriculus variegatus
Biochem. Syst. Ecol.
39
169-174
2011
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8
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-
-
-
-
-
-
-
-
-
6
-
4
-
-
-
-
-
-
-
-
-
-
8
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714458
Chen
Probing the mid-gorge of choli ...
Equus caballus
Bioorg. Med. Chem.
19
1222-1235
2011
-
-
-
-
-
-
24
-
-
-
-
-
-
1
-
-
-
-
-
1
-
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3
-
-
-
-
-
-
-
-
-
-
-
22
-
-
-
-
-
-
-
22
24
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714777
Valbonesi
Cholinesterase activities and ...
Anguilla anguilla
Comp. Biochem. Physiol. C
154
353-359
2011
-
-
-
-
-
-
2
-
-
-
-
-
-
3
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
716278
Xue
Design, preparation, and chara ...
Homo sapiens
Mol. Pharmacol.
79
290-297
2011
-
-
1
-
3
-
-
4
-
-
-
-
-
3
-
-
1
-
-
1
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
4
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
4
4
716433
Rodrigues
-
Cholinesterase (ChE) inhibitio ...
no activity in Lepomis gibbosus
Pestic. Biochem. Physiol.
99
181-188
2011
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
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-
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-
-
-
-
-
-
-
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701889
Kristoff
Inhibition of cholinesterases ...
Biomphalaria glabrata, Lumbriculus variegatus
Aquat. Toxicol.
96
115-123
2010
-
-
-
-
-
-
2
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
702517
Jung
Selective cholinesterase inhib ...
Equus caballus
Biol. Pharm. Bull.
33
267-272
2010
-
-
-
-
-
-
5
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
5
-
-
-
-
-
-
-
5
5
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
702617
Musilek
Preparation and in vitro scree ...
Homo sapiens
Bioorg. Med. Chem. Lett.
20
1763-1766
2010
-
-
-
-
-
-
18
-
-
-
-
-
-
2
-
-
-
-
-
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
18
-
-
-
-
-
-
-
18
18
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702676
Dillon
Isosorbide-based cholinesteras ...
Homo sapiens
Bioorg. Med. Chem.
18
1045-1053
2010
-
-
-
-
-
-
17
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
2
17
-
-
-
-
-
-
-
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-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703556
Katalinic
Structural aspects of flavonoi ...
Homo sapiens
Eur. J. Med. Chem.
45
186-192
2010
-
-
-
-
-
-
9
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
8
-
-
-
-
-
-
-
-
-
-
9
8
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
705921
Suganthy
Neuroprotective effect of seaw ...
Oreochromis niloticus
Neurosci. Lett.
468
216-219
2010
-
-
-
-
-
-
5
6
-
-
-
-
-
8
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
6
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
713701
Umar
-
Butyrylcholinesterase activity ...
Homo sapiens
Afr. J. Biotechnol.
9
4110-4113
2010
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
714388
Frasco
Localization and properties of ...
Palaemon serratus
Biol. Bull.
218
1-5
2010
-
-
-
-
-
-
4
-
-
-
-
-
-
3
-
-
1
-
-
6
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
1
-
6
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714407
Takahashi
Design, synthesis and evaluati ...
Mus musculus
Bioorg. Med. Chem. Lett.
20
1721-1723
2010
-
-
-
-
-
-
22
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
22
-
-
-
-
-
-
-
22
22
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714408
Schulze
Bivalent 5,8,9,13b-tetrahydro- ...
Equus caballus
Bioorg. Med. Chem. Lett.
20
2946-2949
2010
-
-
-
-
-
-
17
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
16
-
-
-
-
-
-
-
16
17
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714409
Yu
Synthesis of 4-[(diethylamino) ...
Equus caballus
Bioorg. Med. Chem. Lett.
20
3254-3258
2010
-
-
-
-
-
-
36
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
36
-
-
-
-
-
-
-
36
36
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714416
Korabecny
Synthesis and in vitro evaluat ...
Homo sapiens
Bioorg. Med. Chem. Lett.
20
6093-6095
2010
-
-
-
-
-
-
10
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
10
10
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714450
Huang
Synthesis and biological evalu ...
Equus caballus
Bioorg. Med. Chem.
18
4475-4484
2010
-
-
-
-
-
-
31
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
30
-
-
-
-
-
-
-
30
31
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714702
Yang
Characterization of a high-act ...
Homo sapiens
Chem. Biol. Interact.
187
148-152
2010
-
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
4
4
714703
Moralev
Investigation of structure-act ...
Equus caballus
Chem. Biol. Interact.
187
153-156
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714705
Kovarik
Pseudo-catalytic scavenging: S ...
Homo sapiens
Chem. Biol. Interact.
187
167-171
2010
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714706
Wong
Interaction study of two diter ...
Homo sapiens
Chem. Biol. Interact.
187
335-339
2010
-
-
-
-
-
-
2
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714780
Darvesh
Biochemical and histochemical ...
Homo sapiens
Curr. Alzheimer Res.
7
386-400
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
714817
Rozengart
Activatory effect of substrate ...
Equus caballus
Dokl. Biochem. Biophys.
430
7-10
2010
3
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
714925
Wolkmer
Trypanosoma evansi: cholineste ...
Rattus norvegicus
Exp. Parasitol.
125
251-255
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
715751
Basova
-
How various substrates activat ...
Equus caballus, Todarodes pacificus
J. Evol. Biochem. Physiol.
46
580-584
2010
6
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
715985
Fernandez-Gomez
Cholinesterase activity in bra ...
Mus musculus
J. Neurosci. Res.
88
155-166
2010
-
-
-
-
-
-
1
-
-
-
-
-
-
5
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
691820
Rizzo
Structure-activity relationshi ...
Homo sapiens
ChemMedChem
4
670-679
2009
-
-
-
-
-
-
25
-
1
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
-
-
-
20
-
-
-
-
-
-
-
20
25
-
-
1
-
-
-
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
691853
Stojanov
Butyrylcholinesterase activity ...
Homo sapiens
Clin. Biochem.
42
22-26
2009
-
1
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692330
Liang
Respective roles of the cataly ...
Homo sapiens
FEBS J.
276
94-108
2009
-
-
-
-
-
-
1
-
-
-
-
2
-
3
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-
-
-
2
1
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
2
1
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701670
Debord
Microcalorimetric study of the ...
Equus caballus
Anal. Biochem.
389
97-101
2009
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
701959
Jung
Cholinesterase and BACE1 inhib ...
Equus caballus
Arch. Pharm. Res.
32
1399-1408
2009
-
-
-
-
-
-
11
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
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-
-
11
-
-
-
-
-
-
-
11
11
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
703470
Hofmann
Serum cholinesterase inhibitio ...
Homo sapiens
Environ. Health Perspect.
117
1402-1408
2009
-
-
-
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
1
-
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-
-
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-
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-
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-
-
-
-
-
-
-
-
-
1
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-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703783
Menichini
Acetylcholinesterase and butyr ...
Equus caballus
Fitoterapia
80
297-300
2009
-
-
-
-
-
-
5
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
703790
Orhan
Cholinesterase inhibitory effe ...
Equus caballus
Food Chem. Toxicol.
47
1747-1751
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
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1
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1
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-
-
-
-
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-
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-
-
-
-
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-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
706041
Elsinghorst
A gorge-spanning, high-affinit ...
Homo sapiens
Org. Biomol. Chem.
7
3940-3946
2009
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
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1
-
1
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
706828
Shenouda
An evaluation of the inhibitio ...
Homo sapiens
Toxicol. Appl. Pharmacol.
241
135-142
2009
-
-
-
-
-
-
1
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
678541
Montenegro
Human butyrylcholinesterase co ...
Homo sapiens
Biol. Chem.
389
425-432
2008
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
4
4
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
4
4
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679238
Gagnaire
Cholinesterase activities as p ...
Potamopyrgus antipodarum, Valvata piscinalis
Chemosphere
71
553-560
2008
-
1
-
-
-
-
7
4
-
-
-
-
-
10
-
-
-
-
-
-
2
-
8
-
-
-
-
-
2
-
-
-
-
-
10
-
1
-
-
-
-
-
10
7
-
4
-
-
-
-
-
-
-
-
-
-
2
-
8
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
682854
Stefano
Cholinesterase activities in t ...
Pecten jacobaeus
Sci. Total Environ.
392
99-109
2008
-
-
-
-
-
-
5
-
-
-
-
3
-
3
-
-
-
-
-
4
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
3
-
-
-
-
-
4
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
690496
Chiou
Activation mechanisms of butyr ...
Equus caballus
Appl. Biochem. Biotechnol.
150
337-344
2008
4
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
690618
Bosak
Amino acid residues involved i ...
Mus musculus
Arch. Biochem. Biophys.
471
72-76
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
690624
Yuecel
Comparative effects of cationi ...
Equus caballus
Arch. Biochem. Biophys.
478
201-205
2008
-
-
-
-
-
-
8
-
1
-
-
-
-
4
-
-
-
-
-
4
-
-
1
-
1
-
-
-
1
-
-
-
9
-
-
-
-
-
-
-
-
-
-
8
9
-
1
-
-
-
-
-
-
-
-
4
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
691094
Grigoryan
Mechanism of hydrolysis of dic ...
Homo sapiens
Biochim. Biophys. Acta
1784
1818-1824
2008
-
-
-
-
-
-
-
1
1
-
-
-
-
2
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691103
Bromberg
Kinetic study of the thermal i ...
Homo sapiens
Biochim. Biophys. Acta
1784
961-966
2008
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
1
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
691219
Decker
Design, synthesis and pharmaco ...
Mus musculus
Bioorg. Med. Chem.
16
4252-4261
2008
-
-
-
-
-
-
11
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
1
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
1
11
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
691289
Pan
Design, synthesis and evaluati ...
Equus caballus
Bioorg. Med. Chem. Lett.
18
3790-3793
2008
-
-
-
-
-
-
13
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
9
13
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691739
Sperling
Characterisation of cholineste ...
Mus musculus
Chem. Biol. Interact.
175
156-160
2008
-
-
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
5
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
5
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691741
Masson
A collaborative endeavor to de ...
Homo sapiens
Chem. Biol. Interact.
175
273-280
2008
-
-
-
-
2
-
-
-
1
-
-
1
-
4
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691743
Massoulie
Old and new questions about ch ...
Homo sapiens
Chem. Biol. Interact.
175
30-44
2008
1
-
1
-
1
-
-
-
2
-
-
1
-
1
-
-
-
-
-
1
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691744
Calic
Interactions of butane, but-2- ...
Homo sapiens
Chem. Biol. Interact.
175
305-308
2008
-
-
-
-
-
-
4
-
1
-
-
-
-
2
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
4
3
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691745
Geyer
Increased organophosphate scav ...
Homo sapiens
Chem. Biol. Interact.
175
376-379
2008
-
-
1
-
1
-
7
2
-
-
-
1
-
4
-
-
-
-
-
-
1
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
7
-
2
-
-
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
691746
Jun
Potency of several oximes to r ...
Homo sapiens
Chem. Biol. Interact.
175
421-424
2008
-
-
-
-
-
-
7
-
1
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691747
Li
Fast affinity purification cou ...
Homo sapiens
Chem. Biol. Interact.
175
68-72
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691748
Gao
An albumin-butyrylcholinestera ...
Homo sapiens
Chem. Biol. Interact.
175
83-87
2008
-
-
-
-
1
-
-
-
-
-
-
4
-
4
-
-
-
-
-
1
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691749
Anglister
Cholinesterases in development ...
Mus musculus
Chem. Biol. Interact.
175
92-100
2008
-
-
-
-
-
-
1
-
1
-
-
1
-
5
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691782
Grigoryan
alpha,beta -Dehydrophenylalani ...
Homo sapiens
Chem. -Biol. Interact.
171
108-116
2008
-
-
-
-
-
-
18
-
1
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
15
-
-
-
-
-
-
-
15
18
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
691944
Loizzo
Natural products and their der ...
Equus caballus, Homo sapiens
Curr. Med. Chem.
15
1209-1228
2008
-
-
-
-
-
-
230
-
1
-
-
1
-
3
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
20
-
-
-
-
-
-
-
20
230
-
-
1
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692056
Rodriguez-Fuentes
Characterization of muscle cho ...
Parophrys vetulus, Pleuronichthys verticalis
Ecotoxicol. Environ. Saf.
69
466-471
2008
-
-
-
-
-
-
10
2
-
-
-
-
-
7
-
-
-
-
-
2
-
-
2
-
2
-
-
-
2
-
-
-
-
-
19
-
-
-
-
-
-
-
19
10
-
2
-
-
-
-
-
-
-
-
-
2
-
-
2
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
692175
Belluti
Design, synthesis, and evaluat ...
Homo sapiens
Eur. J. Med. Chem.
44
1341-1348
2008
-
-
-
-
-
-
13
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
12
-
-
-
-
-
-
-
12
13
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
692179
Jia
Design, synthesis and evaluati ...
Rattus norvegicus
Eur. J. Med. Chem.
44
772-784
2008
-
-
-
-
-
-
21
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
20
-
-
-
-
-
-
-
20
21
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
693392
Ahmad
Butyrylcholinesterase, lipoxyg ...
Equus caballus
J. Enzyme Inhib. Med. Chem.
23
313-316
2008
-
-
-
-
-
-
8
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
7
-
-
-
-
-
-
-
7
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
693395
Ahmed
Comparative study of the inhib ...
Homo sapiens
J. Enzyme Inhib. Med. Chem.
23
912-917
2008
-
-
-
-
-
-
5
-
1
-
-
-
-
5
-
-
-
-
-
15
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
1
-
-
-
-
-
-
-
-
15
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
693399
Al-Aboudi
Butyrylcholinesterase inhibito ...
Equus caballus
J. Enzyme Inhib. Med. Chem.
24
553-558
2008
-
-
-
-
-
-
13
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
12
-
-
-
-
-
-
-
12
13
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693402
Rozengart
-
Thiosubstrates of cholinestera ...
Acyrthosiphon pisum, Berryteuthis magister, Coccinella septempunctata, Columba livia, Delia antiqua, Delia floralis, Drosophila melanogaster, Eogonatus tinro, Equus caballus, Gonatopsis borealis, Gonatus kamtschaticus, Helicoverpa armigera, Locusta migratoria migratorioides, Musca domestica, Neovison vison, Nippostrongylus brasiliensis, no activity in Acheta domesticus, no activity in Bos taurus, no activity in Branchiostoma floridae, no activity in Electrophorus electricus, no activity in Solanum melongena, no activity in Tetranychus urticae, no activity in Torpedo marmorata, no activity in Triatoma infestans, no activity in Zea mays, Okutania anonycha, Oryctolagus cuniculus, Schizaphis graminum, Todarodes pacificus, Triatoma infestans
J. Evol. Biochem. Physiol.
44
12-23
2008
-
-
-
-
-
-
-
21
-
-
-
21
-
30
-
-
-
-
-
21
21
-
22
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
21
-
-
-
21
-
-
-
-
-
21
21
-
22
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693553
Darvesh
Carbamates with differential m ...
Homo sapiens
J. Med. Chem.
51
4200-4212
2008
-
-
-
-
7
-
33
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
14
-
-
-
-
-
-
-
7
-
-
33
14
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
693565
Rivera-Becerril
Synthesis and biological evalu ...
Homo sapiens
J. Med. Chem.
51
5271-5284
2008
-
-
-
-
-
-
14
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
11
-
-
-
-
-
-
-
11
14
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693570
Carolan
Isosorbide-2-carbamate esters: ...
Homo sapiens
J. Med. Chem.
51
6400-6409
2008
-
-
-
-
-
-
33
-
1
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
24
-
-
-
-
-
-
-
24
33
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
694365
Podoly
Human recombinant butyrylcholi ...
Homo sapiens
Neurodegener. Dis.
5
232-236
2008
-
-
1
-
-
-
-
-
1
-
-
1
-
4
-
-
1
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694383
Tasker
Butyrylcholinesterase K varian ...
Homo sapiens
Neurosci. Lett.
442
297-299
2008
-
-
1
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694563
Mikami
Five new naturally occurring m ...
Homo sapiens
Pharmacogenet. Genomics
18
213-218
2008
-
-
1
-
12
-
-
5
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
1
-
-
5
1
-
-
-
-
-
-
-
-
1
-
-
12
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
5
1
-
-
-
-
-
-
-
-
-
694972
Saxena
Developing procedures for the ...
Homo sapiens
Protein Expr. Purif.
61
191-196
2008
-
1
-
-
-
-
-
-
1
-
2
-
-
2
-
-
1
-
-
2
2
1
-
1
1
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
1
-
2
2
1
-
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
695065
Kolarich
Glycoproteomic characterizatio ...
Homo sapiens
Proteomics
8
254-263
2008
-
-
-
-
-
-
-
-
1
-
-
6
-
2
-
1
-
-
-
2
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
6
-
-
1
-
-
2
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695200
Worek
Inhibition, reactivation and a ...
Sus scrofa
Toxicology
244
35-41
2008
-
-
-
-
-
-
1
1
1
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
1
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
695282
Orhan
Screening of various phenolic ...
Homo sapiens
Z. Naturforsch. C
62
829-832
2008
-
-
-
-
-
-
10
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695283
Gholivand
Some new carbacylamidophosphat ...
Homo sapiens
Z. Naturforsch. C
63
241-250
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
1
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
695284
Orhan
Coumarin, anthroquinone and st ...
Equus caballus
Z. Naturforsch. C
63
366-370
2008
-
-
-
-
-
-
6
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695287
Orhan
Activity of essential oils and ...
Equus caballus
Z. Naturforsch. C
63
547-553
2008
-
-
-
-
-
-
44
-
1
-
-
-
-
12
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
44
-
-
1
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706753
Frasco
Does mercury interact with the ...
Palaemon serratus
Sci. Total Environ.
404
88-93
2008
-
1
-
-
-
-
2
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
677385
Ngamelue
Crystallization and X-ray stru ...
Homo sapiens
Acta Crystallogr. Sect. F
63
723-727
2007
-
1
1
1
-
-
-
-
1
-
2
2
-
3
-
1
1
-
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
1
-
2
2
-
-
1
1
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677953
Schallreuter
Calcium-activated butyrylcholi ...
Homo sapiens
Biochem. Biophys. Res. Commun.
355
1069-1074
2007
-
-
-
-
-
-
-
-
2
1
-
2
-
2
-
-
-
-
-
2
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
2
-
-
-
-
-
2
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
678430
Walsh
A versatile equation to descri ...
Homo sapiens
Biochim. Biophys. Acta
1770
733-746
2007
3
-
-
-
-
-
1
1
1
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
1
-
-
3
-
-
-
-
-
-
-
1
1
1
1
-
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
678453
Masson
Kinetic analysis of butyrylcho ...
Homo sapiens
Biochim. Biophys. Acta
1774
1139-1147
2007
-
-
1
-
3
-
2
1
-
-
-
1
-
2
-
-
1
1
-
-
-
-
6
2
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
3
-
-
2
-
1
-
-
-
1
-
-
-
1
-
-
-
-
6
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
678608
Piazzi
Cholinesterase inhibitors: SAR ...
Homo sapiens
Bioorg. Med. Chem.
15
575-585
2007
-
-
-
-
-
-
28
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
27
-
-
-
-
-
-
-
27
28
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679287
Boopathy
Human serum cholinesterase fro ...
Homo sapiens
Clin. Chim. Acta
380
151-156
2007
-
-
-
-
-
-
2
-
1
-
-
2
-
2
-
-
-
-
-
4
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
2
-
-
-
-
-
4
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
679334
Rault
-
Tissue distribution and charac ...
Aporrectodea caliginosa, Aporrectodea nocturna, Aporrectodea rosea, Lumbricus castaneus, Lumbricus terrestris
Comp. Biochem. Physiol. B
147B
340-346
2007
-
-
-
-
-
-
15
-
-
-
-
5
-
5
-
-
-
-
-
15
5
-
19
-
5
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
15
-
-
-
-
-
5
-
-
-
-
-
15
5
-
19
-
5
-
-
-
5
-
-
-
-
-
-
-
-
-
679471
Bajgar
Changes of cholinesterase acti ...
Equus caballus, Rattus norvegicus
Drug Chem. Toxicol.
30
351-359
2007
1
-
-
-
-
-
1
-
2
-
-
3
-
5
-
-
-
-
-
16
2
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
2
-
-
3
-
-
-
-
-
16
2
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679536
Aamodt
Recovery of cholinesterase act ...
Eisenia fetida
Environ. Toxicol. Chem.
26
1963-1967
2007
-
-
-
-
-
-
2
-
-
-
-
-
-
5
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680586
Chiou
Substrate activation of butyry ...
Equus caballus
J. Biochem. Mol. Toxicol.
21
24-31
2007
2
-
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
681113
Rozengart
-
How thionphosphonates inhibit ...
Berryteuthis magister, Equus caballus
J. Evol. Biochem. Physiol.
43
164-173
2007
-
-
-
-
-
-
2
-
1
-
-
2
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
1
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681725
Ko
Temporospatial localization of ...
Mus musculus
Life Sci.
81
1235-1240
2007
-
-
-
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2
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1
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3
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3
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2
-
1
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1
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2
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1
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3
-
-
2
-
1
-
-
-
1
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-
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-
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681741
Jung
Characterization of cholineste ...
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Mar. Environ. Res.
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5
1
1
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1
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2
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-
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-
-
1
-
-
1
-
-
-
-
-
1
1
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3
-
-
-
-
-
-
-
-
-
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5
3
1
1
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
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682017
Groner
The kinetics of inhibition of ...
Homo sapiens
Mol. Pharmacol.
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2
1
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1
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1
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2
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1
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-
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1
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1
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2
1
1
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-
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1
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-
1
-
-
2
-
1
-
-
-
1
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682120
Kamal
Kinetics of human serum butyry ...
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Neurochem. Res.
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2
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3
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2
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1
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-
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1
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1
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2
1
-
1
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-
1
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3
-
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2
-
1
-
-
-
1
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-
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682920
Bartling
Enzyme-kinetic investigation o ...
Homo sapiens
Toxicology
233
166-172
2007
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9
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1
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1
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1
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-
1
-
1
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-
-
1
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-
1
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9
1
-
1
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-
1
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-
1
-
-
1
-
1
-
-
-
1
-
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663805
Petroianu
Effect of pyridostigmine, pral ...
Rattus norvegicus
Arch. Toxicol.
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777-84
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1
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2
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663895
Kovarik
Active site mutant acetylcholi ...
Mus musculus
Biochem. Biophys. Res. Commun.
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2006
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3
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2
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664213
Kamal
Kinetic analysis of the inhibi ...
Homo sapiens
Biochim. Biophys. Acta
1760
200-206
2006
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1
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1
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1
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664534
Martinez-Moreno
Cholinesterase activity of hum ...
Homo sapiens
Carcinogenesis
27
429-436
2006
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1
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2
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3
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1
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3
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664907
Hrabovska
Rat butyrylcholinesterase-cata ...
Rattus norvegicus
FEBS J.
273
1185-1197
2006
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1
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2
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1
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1
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-
-
2
-
-
-
-
1
-
-
-
-
-
-
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-
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-
666882
Gao
Modeling evolution of hydrogen ...
Homo sapiens
Proteins
62
99-110
2006
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-
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-
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-
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-
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2
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1
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-
1
-
-
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-
-
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-
-
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667928
Darvesh
On the active site for hydroly ...
Homo sapiens
Bioorg. Med. Chem.
14
4586-4599
2006
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-
-
-
-
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2
1
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2
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3
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2
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1
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-
-
3
-
-
-
-
-
-
-
-
-
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-
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-
679344
Caselli
In vitro characterization of c ...
Eisenia andrei
Comp. Biochem. Physiol. C
143
416-421
2006
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4
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3
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-
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3
-
3
-
1
-
-
-
1
-
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-
4
-
-
-
-
-
-
-
4
4
-
-
-
-
-
-
-
-
-
-
-
-
3
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
679345
Caselli
-
In vitro characterization of c ...
Eisenia andrei
Comp. Biochem. Physiol. C
143C
416-421
2006
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4
2
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1
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-
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3
-
3
-
1
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-
1
-
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4
-
-
-
-
-
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-
4
4
-
2
-
-
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-
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-
-
-
3
-
3
-
1
-
-
-
1
-
-
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679534
Van Cong
Sensitivity of brain cholinest ...
Channa striata
Environ. Toxicol. Chem.
25
1418-1425
2006
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2
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5
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3
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3
-
-
-
-
-
-
-
-
-
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-
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-
-
-
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682916
Kristoff
Inhibition of cholinesterase a ...
Biomphalaria glabrata, Lumbriculus variegatus
Toxicology
222
185-194
2006
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-
-
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-
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8
-
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6
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6
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-
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8
-
2
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
2
8
-
-
-
-
-
6
-
-
-
-
-
-
-
-
8
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
683010
Zdrazilova
Kinetics of 13 new cholinester ...
Equus caballus
Z. Naturforsch. C
61
611-617
2006
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-
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18
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1
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4
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1
1
-
-
-
1
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
18
1
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
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1
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663576
Bailey
Studies of the inhibition of s ...
Homo sapiens
Am. J. Clin. Pathol.
124
226-228
2005
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1
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4
-
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1
-
-
-
-
-
-
-
-
-
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-
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663771
Kucukkilinc
Inhibition of human plasma cho ...
Homo sapiens
Arch. Biochem. Biophys.
440
118-122
2005
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-
-
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3
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3
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-
3
-
-
1
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
664059
Nachon
Role of water in aging of huma ...
Homo sapiens
Biochemistry
44
1154-1162
2005
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1
-
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-
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3
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-
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1
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-
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-
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-
-
-
-
-
-
-
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664337
Zhan
Catalytic mechanism and energy ...
Equus caballus
Biophys. J.
89
3863-3872
2005
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-
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10
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
10
7
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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664577
Saxena
Human serum butyrylcholinester ...
Homo sapiens
Chem. Biol. Interact.
157-158
199-203
2005
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1
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-
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3
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-
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2
-
5
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-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
2
-
5
-
-
-
-
-
-
-
-
-
-
-
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664579
Cerasoli
In vitro and in vivo character ...
Homo sapiens
Chem. Biol. Interact.
157-158
363-365
2005
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7
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-
-
-
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6
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-
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1
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-
-
-
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-
13
-
-
-
-
-
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-
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-
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7
13
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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664593
Lin
Ortho effects for inhibition m ...
Equus caballus
Chem. Res. Toxicol.
18
1124-1131
2005
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-
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10
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-
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1
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-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
10
9
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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664595
Schopfer
Reaction kinetics of biotinyla ...
Homo sapiens
Chem. Res. Toxicol.
18
747-754
2005
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-
-
-
-
-
3
-
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-
-
-
-
2
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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665304
Tormos
The reactant state for substra ...
Homo sapiens
J. Am. Chem. Soc.
127
14538-14539
2005
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1
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-
1
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
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-
-
-
-
-
1
-
-
-
-
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665819
Chiou
-
Kinetics and mechanisms of ace ...
Equus caballus
J. Chin. Chem. Soc.
52
843-848
2005
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7
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1
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-
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-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
7
7
-
-
-
-
-
-
-
-
-
-
1
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-
-
-
-
-
-
-
-
-
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665984
Luo
Novel anticholinesterases base ...
Homo sapiens
J. Med. Chem.
48
986-994
2005
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23
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2
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1
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-
-
-
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-
-
-
-
-
-
-
-
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-
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-
23
-
-
-
-
-
-
-
-
-
-
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1
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-
-
-
-
-
-
-
-
-
-
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666156
Gao
Modeling effects of oxyanion h ...
Homo sapiens
J. Phys. Chem. B
109
23070-23076
2005
-
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-
-
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2
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3
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-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
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3
-
-
-
-
-
-
-
-
-
-
-
-
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666874
Suarez
Molecular dynamics simulations ...
Homo sapiens
Proteins
59
104-117
2005
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-
-
-
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3
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1
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-
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-
-
-
-
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649772
Cohen
Amino acid domains control the ...
Macaca mulatta
Biochem. J.
378
117-128
2004
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1
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1
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1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650246
Kovarik
Mutant cholinesterases possess ...
Mus musculus
Biochemistry
43
3222-3229
2004
-
-
-
-
-
-
6
-
-
-
-
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-
2
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1
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6
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-
-
1
-
-
-
-
-
-
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-
-
-
-
-
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-
-
651173
Masson
Damped oscillatory hysteretic ...
Homo sapiens
Eur. J. Biochem.
271
220-234
2004
-
-
1
-
1
-
-
4
-
-
-
-
-
2
-
-
-
-
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-
3
-
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4
1
1
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-
-
1
-
-
1
-
-
-
-
4
-
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-
-
-
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-
-
-
-
-
3
-
-
-
-
4
1
1
-
-
-
-
-
-
-
-
653775
Yildiz
Partial purification and chara ...
Rattus norvegicus
Protein J.
23
143-151
2004
-
-
-
-
-
-
2
4
-
-
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-
3
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1
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-
2
1
-
4
1
1
-
-
4
1
-
-
-
-
-
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-
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-
2
-
4
-
-
-
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1
-
2
1
-
4
1
1
-
-
4
1
-
-
-
-
-
-
-
-
-
653989
Ashani
The effect of fluoride on the ...
Homo sapiens
Toxicol. Appl. Pharmacol.
194
90-99
2004
-
-
-
-
-
-
6
-
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2
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2
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1
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1
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1
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6
1
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-
2
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
664303
Darvesh
Structure-activity relationshi ...
Homo sapiens
Bioorg. Med. Chem.
13
211-222
2004
-
-
-
-
-
-
24
-
-
-
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2
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24
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24
24
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-
-
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-
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-
-
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-
-
-
-
664735
Rozengart
Elementorganic bisonium revers ...
Berryteuthis magister, Equus caballus
Dokl. Biochem. Biophys.
395
99-103
2004
-
-
-
-
-
-
24
-
-
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-
2
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2
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24
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
664821
Masson
Rate-determining step of butyr ...
Homo sapiens
Eur. J. Biochem.
271
1980-1990
2004
-
-
-
-
1
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-
4
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2
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2
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4
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1
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4
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-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
665855
Kovalev
-
Comparative study of substrate ...
Berryteuthis magister, Oncorhynchus gorbuscha, Oncorhynchus keta, Oncorhynchus kisutch, Oncorhynchus nerka, Salmo salar
J. Evol. Biochem. Physiol.
40
258-263
2004
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-
-
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-
-
36
18
-
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6
-
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-
-
6
-
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18
-
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36
-
18
-
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6
-
-
18
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666232
Rodriguez-Fuentes
Characterization of cholineste ...
Oreochromis niloticus
Mar. Environ. Res.
58
505-509
2004
-
-
-
-
-
-
3
-
-
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-
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2
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3
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-
3
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3
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-
3
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666699
Mehrani
-
Simplified procedures for puri ...
Homo sapiens
Proc. Biochem.
39
877-882
2004
-
-
-
-
-
1
7
2
-
1
1
-
-
1
-
-
1
-
-
1
-
6
2
1
1
-
-
-
1
-
-
-
-
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-
-
-
-
-
-
-
1
-
7
-
2
-
1
1
-
-
-
-
1
-
1
-
6
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
651156
Masson
High activity of human butyryl ...
Homo sapiens
Eur. J. Biochem.
270
315-324
2003
-
-
1
-
9
-
-
-
-
-
-
-
-
2
-
-
1
1
-
1
-
-
1
-
-
-
-
17
-
1
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-
-
-
-
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-
1
-
-
9
-
-
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-
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1
-
1
-
-
1
-
-
-
-
17
-
1
-
-
-
-
-
-
-
-
651163
Saxena
Aromatic amino-acid residues a ...
Equus caballus, Homo sapiens
Eur. J. Biochem.
270
4447-4458
2003
-
-
-
-
8
-
3
-
-
-
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7
-
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2
-
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-
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-
10
-
-
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8
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3
10
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-
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-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651187
Primozic
-
Stereoselective hydrolysis of ...
Equus caballus
Eur. J. Org. Chem.
2003
295-301
2003
-
-
-
-
-
-
1
3
-
-
-
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1
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1
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6
-
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-
3
-
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-
1
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-
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-
-
-
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-
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-
1
1
3
-
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-
-
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-
1
-
-
6
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
651593
Zhan
Fundamental reaction mechanism ...
Homo sapiens
J. Am. Chem. Soc.
125
2462-2474
2003
-
-
-
-
-
-
2
-
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2
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1
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2
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2
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2
2
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-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652467
Nicolet
Crystal structure of human but ...
Homo sapiens
J. Biol. Chem.
278
41141-41147
2003
-
-
-
1
-
-
-
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4
-
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1
-
-
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-
1
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-
1
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-
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1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652646
Zhukovskii
-
On establishment of individual ...
Equus caballus
J. Evol. Biochem. Physiol.
39
281-290
2003
-
-
-
-
-
-
2
-
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1
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1
1
-
1
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2
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1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
653108
Brown
Characterization of choline es ...
Mytilus edulis
Mar. Environ. Res.
57
155-169
2003
-
-
-
-
-
-
1
-
2
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-
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4
-
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-
2
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1
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1
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2
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-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
653355
Giacobini
Cholinesterases: New roles in ...
Homo sapiens
Neurochem. Res.
28
515-522
2003
-
-
-
-
-
-
15
-
-
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-
1
-
6
-
-
-
-
-
3
-
-
3
-
-
-
-
-
-
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-
-
15
-
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-
1
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-
-
3
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
649453
Golicnik
Kinetic Model of ethopropazine ...
Equus caballus
Arch. Biochem. Biophys.
398
23-31
2002
-
-
-
-
-
-
1
-
-
-
-
1
-
3
-
-
1
-
-
2
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
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-
1
-
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-
1
-
2
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
649795
Boeck
DNA sequence of butyrylcholine ...
Rattus norvegicus
Biochem. Pharmacol.
63
2101-2110
2002
-
-
1
-
1
-
2
6
-
-
-
-
-
4
-
-
1
-
-
1
-
-
5
-
-
-
-
1
-
-
-
-
-
-
-
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1
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-
1
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2
-
6
-
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-
-
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-
1
-
1
-
-
5
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
650141
Bar-On
Kinetic and structural studies ...
Homo sapiens
Biochemistry
41
3555-3564
2002
-
-
-
-
-
-
1
-
-
-
-
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5
-
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-
1
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-
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-
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-
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-
1
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-
-
-
-
-
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-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650381
Masson
Butyrylcholinesterase-catalyze ...
Homo sapiens
Biochim. Biophys. Acta
1597
229-243
2002
-
-
1
-
3
-
-
4
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-
-
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2
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-
-
-
-
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-
2
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3
-
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-
-
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-
1
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-
3
-
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4
-
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-
-
-
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-
-
-
-
-
2
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
650956
Koetzner
Characterization of equine but ...
Equus sp.
Drug Metab. Dispos.
30
724-730
2002
-
-
-
-
-
-
-
-
-
-
-
-
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4
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-
1
-
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3
-
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-
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-
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-
-
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-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651010
Sanchez-Hernandez
Lizard cholinesterases as biom ...
Gallotia galloti
Environ. Toxicol. Chem.
21
2319-2325
2002
-
-
-
-
-
-
3
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
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-
-
-
-
-
-
-
-
-
-
-
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3
-
1
-
-
-
-
-
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-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
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651144
Nachon
Engineering of a monomeric and ...
Homo sapiens
Eur. J. Biochem.
269
630-637
2002
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1
1
1
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1
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2
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2
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1
1
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-
1
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-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
1
-
-
2
-
-
-
1
1
-
1
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
652645
Rozengart
-
Indophenol chromogenic substra ...
Equus sp.
J. Evol. Biochem. Physiol.
38
16-23
2002
-
-
-
-
-
-
-
-
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1
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1
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5
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
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653036
Cengiz
A new perspective on thermal i ...
Homo sapiens
J. Protein Chem.
21
145-149
2002
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-
-
-
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3
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2
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1
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2
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1
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2
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6
-
-
-
-
-
-
-
-
-
-
3
6
-
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
-
2
-
-
-
-
-
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-
-
-
-
-
653283
Sun
Re-engineering butyrylcholines ...
Homo sapiens
Mol. Pharmacol.
62
220-224
2002
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1
-
3
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-
4
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-
-
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2
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3
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6
-
1
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-
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-
-
-
1
-
-
3
-
-
-
-
4
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-
-
-
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-
-
-
-
-
3
-
-
-
-
6
-
1
-
-
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649707
Weingand-Ziade
Pressure- and heat-induced ina ...
Homo sapiens
Biochem. J.
356
487-493
2001
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-
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1
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1
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1
-
1
1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
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-
1
-
-
1
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-
-
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650347
Masson
Effects of mutations of active ...
Homo sapiens
Biochim. Biophys. Acta
1544
166-176
2001
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11
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2
17
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3
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17
-
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-
-
7
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-
-
-
-
-
-
11
-
-
2
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10
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94441
Lockridge
Comparison of atypical and usu ...
Homo sapiens
J. Biol. Chem.
253
361-366
1978
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5
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1
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2
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1
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2
1
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5
1
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3
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5
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1
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1
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2
1
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5
1
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3
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94442
Vigny
Nonspecific cholinesterase and ...
Rattus norvegicus
Proc. Natl. Acad. Sci. USA
75
2588-2592
1978
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94440
Nagasawa
Purification and characterizat ...
Pseudomonas aeruginosa
Biochim. Biophys. Acta
429
817-827
1976
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13
1
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1
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1
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20
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2
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1
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3
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13
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1
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1
1
20
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2
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1
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3
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94438
Fluck
Cholinesterase from plant tiss ...
Solanum melongena
Biochim. Biophys. Acta
410
130-134
1975
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4
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1
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7
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1
1
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3
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1
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4
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1
1
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3
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1
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94439
Alsen
Studies on acetylcholinesteras ...
Equus caballus
Biochim. Biophys. Acta
377
297-302
1975
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1
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1
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1
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1
1
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1
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2
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1
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35203
Ecobichon
Characterization of the estera ...
Felis catus
Can. J. Biochem.
52
1073-1078
1974
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1
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1
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1
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1
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94437
Main
The purification of cholineste ...
Equus caballus
Biochem. J.
143
733-744
1974
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1
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2
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1
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2
1
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1
1
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2
1
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1
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94434
Riov
Cholinesterases from plant tis ...
Vigna radiata var. radiata
Plant Physiol.
51
520-528
1973
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10
2
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4
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1
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1
1
1
5
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1
1
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2
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10
2
2
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1
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1
1
1
5
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1
1
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94435
Lee
Physical properties and subuni ...
Equus caballus
Biochemistry
12
1622-1630
1973
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94432
Main
Purification of horse serum ch ...
Equus caballus
J. Biol. Chem.
247
566-571
1972
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2
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2
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2
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1
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1
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2
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2
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2
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1
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2
1
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2
1
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2
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94433
Wheeler
Cholinesterase activities in s ...
Rattus norvegicus
Biochim. Biophys. Acta
255
917-930
1972
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2
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2
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2
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2
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4
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2
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2
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4
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94431
Voigtmann
Reinigung einer 'Pseudo'-Choli ...
Helix pomatia
Z. Naturforsch. B
26
1374-1375
1971
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1
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1
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1
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1
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1
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1
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1
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