BRENDA - Enzyme Database show
show all sequences of 3.1.1.67

Fatty acid ethyl ester synthase, an enzyme for nonoxidative ethanol metabolism, is present in serum after liver and pancreatic injury

Aleryani, S.; Kabakibi, A.; Cluette-Brown, J.; Laposata, M.; Clin. Chem. 42, 24-27 (1996)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
enzyme is responsible for the formation of fatty acid ethyl esters, which are mediators of ethanol-induced organ damage; patients with liver or pancreatic disease release FAEE synthase into their plasma
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
both cytosolic and membrane-bound
Homo sapiens
5829
-
membrane
both cytosolic and membrane-bound
Homo sapiens
16020
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
fatty acid + ethanol
Homo sapiens
patients with liver or pancreatic disease release FAEE synthase into their plasma permitting nonoxidative ethanol metabolism in the plasma
fatty acyl ethyl ester + H2O
responsible for the formation of FAEE, which are mediators of ethanol-induced organ damage
Homo sapiens
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
erythrocyte
substantially lower activity in erythrocytes than in leukocytes
Homo sapiens
-
leukocyte
substantially lower activity in erythrocytes than in leukocytes
Homo sapiens
-
liver
highest activity in liver and pancreas
Homo sapiens
-
pancreas
highest activity in liver and pancreas
Homo sapiens
-
plasma
low activity in normal plasma samples, patients with liver or pancreatic disease release FAEE synthase into their plasma
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
arachidonate + ethanol
-
646073
Homo sapiens
ethyl arachidonate + H2O
-
646073
Homo sapiens
?
fatty acid + ethanol
-
646073
Homo sapiens
fatty acyl ethyl ester + H2O
-
646073
Homo sapiens
?
fatty acid + ethanol
patients with liver or pancreatic disease release FAEE synthase into their plasma permitting nonoxidative ethanol metabolism in the plasma
646073
Homo sapiens
fatty acyl ethyl ester + H2O
responsible for the formation of FAEE, which are mediators of ethanol-induced organ damage
646073
Homo sapiens
?
oleate + ethanol
-
646073
Homo sapiens
ethyl oleate + H2O
-
646073
Homo sapiens
?
palmitate + ethanol
-
646073
Homo sapiens
ethyl palmitate + H2O
-
646073
Homo sapiens
?
stearate + ethanol
-
646073
Homo sapiens
ethyl stearate + H2O
-
646073
Homo sapiens
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
Application (protein specific)
Application
Commentary
Organism
medicine
enzyme is responsible for the formation of fatty acid ethyl esters, which are mediators of ethanol-induced organ damage; patients with liver or pancreatic disease release FAEE synthase into their plasma
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
both cytosolic and membrane-bound
Homo sapiens
5829
-
membrane
both cytosolic and membrane-bound
Homo sapiens
16020
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
fatty acid + ethanol
Homo sapiens
patients with liver or pancreatic disease release FAEE synthase into their plasma permitting nonoxidative ethanol metabolism in the plasma
fatty acyl ethyl ester + H2O
responsible for the formation of FAEE, which are mediators of ethanol-induced organ damage
Homo sapiens
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
erythrocyte
substantially lower activity in erythrocytes than in leukocytes
Homo sapiens
-
leukocyte
substantially lower activity in erythrocytes than in leukocytes
Homo sapiens
-
liver
highest activity in liver and pancreas
Homo sapiens
-
pancreas
highest activity in liver and pancreas
Homo sapiens
-
plasma
low activity in normal plasma samples, patients with liver or pancreatic disease release FAEE synthase into their plasma
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
arachidonate + ethanol
-
646073
Homo sapiens
ethyl arachidonate + H2O
-
646073
Homo sapiens
?
fatty acid + ethanol
-
646073
Homo sapiens
fatty acyl ethyl ester + H2O
-
646073
Homo sapiens
?
fatty acid + ethanol
patients with liver or pancreatic disease release FAEE synthase into their plasma permitting nonoxidative ethanol metabolism in the plasma
646073
Homo sapiens
fatty acyl ethyl ester + H2O
responsible for the formation of FAEE, which are mediators of ethanol-induced organ damage
646073
Homo sapiens
?
oleate + ethanol
-
646073
Homo sapiens
ethyl oleate + H2O
-
646073
Homo sapiens
?
palmitate + ethanol
-
646073
Homo sapiens
ethyl palmitate + H2O
-
646073
Homo sapiens
?
stearate + ethanol
-
646073
Homo sapiens
ethyl stearate + H2O
-
646073
Homo sapiens
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
Other publictions for EC 3.1.1.67
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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1516-1520
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750562
De Jong
Physiological and transcripti ...
Saccharomyces cerevisiae
FEMS Yeast Res.
16
fov105
2015
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1
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-
-
-
-
-
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679736
Bora
Alcohol linked to enhanced ang ...
Rattus norvegicus
FEBS J.
273
1403-1414
2006
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2
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1
1
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666181
Mericle
Modulation of fatty acid methy ...
Rattus norvegicus
J. Toxicol. Environ. Health
67
583-593
2004
-
-
-
-
-
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1
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4
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4
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1
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1
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4
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1
-
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-
666967
Kaphalia
Mechanism of differential inhi ...
Homo sapiens, Rattus norvegicus
Toxicol. Appl. Pharmacol.
200
7-15
2004
-
-
-
-
-
-
3
-
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5
-
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2
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2
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3
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2
-
-
2
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646070
Mericle
Differential inhibition of hep ...
Rattus norvegicus
Toxicol. Appl. Pharmacol.
179
119-125
2002
-
-
-
-
-
-
1
-
-
-
2
-
-
5
-
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6
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3
1
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-
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-
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1
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2
-
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-
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6
-
-
3
1
-
-
-
-
-
-
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-
-
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-
-
-
-
646074
Kaphalia
Purification and characterizat ...
Rattus norvegicus
J. Biochem. Mol. Toxicol.
15
165-171
2001
-
-
-
-
-
-
-
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1
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2
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-
2
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1
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2
5
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2
2
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5
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1
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2
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1
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2
5
-
2
2
-
-
-
-
-
-
-
5
-
-
-
-
-
-
646076
Diczfalusy
Characterization of enzymes in ...
Homo sapiens
J. Lipid Res.
42
1025-1032
2001
-
-
-
-
-
-
-
-
1
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1
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2
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9
1
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4
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1
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1
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1
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9
1
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4
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1
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-
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-
-
-
-
646075
Kaphalia
Fatty acid ethyl and methyl es ...
Homo sapiens, Rattus norvegicus
Toxicol. Appl. Pharmacol.
159
134-141
1999
-
-
-
-
-
-
3
-
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-
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6
-
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-
4
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10
-
2
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2
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3
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4
-
-
10
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
646077
Bora
Mutagenesis and characterizati ...
Homo sapiens
Mol. Cell. Biochem.
180
111-115
1998
-
-
1
-
3
-
-
-
-
-
1
1
-
1
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1
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1
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3
1
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1
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3
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1
1
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1
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3
1
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-
646078
Kaphalia
Purification and characterizat ...
Rattus norvegicus
Chem. Res. Toxicol.
10
211-218
1997
-
-
-
-
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-
1
1
1
-
2
1
-
2
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1
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2
1
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7
1
1
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1
1
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1
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1
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1
1
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2
1
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1
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2
1
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7
1
1
-
-
1
1
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1
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-
-
646071
Treloar
Fatty acid ethyl ester synthes ...
Homo sapiens
Biochim. Biophys. Acta
1299
160-166
1996
-
-
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2
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3
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2
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1
2
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2
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1
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-
646073
Aleryani
Fatty acid ethyl ester synthas ...
Homo sapiens
Clin. Chem.
42
24-27
1996
-
1
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2
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1
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2
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5
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6
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1
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1
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1
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5
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6
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1
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646079
Bora
Purification and characterizat ...
Homo sapiens
J. Mol. Cell. Cardiol.
28
2027-2032
1996
-
-
-
-
-
-
-
2
3
-
1
1
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3
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1
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2
1
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4
1
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3
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1
1
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1
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2
1
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4
1
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-
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646072
Heith
Fatty acid ethyl ester synthas ...
Homo sapiens
Biochem. Biophys. Res. Commun.
208
549-554
1995
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1
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2
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646068
Tsujita
Fatty acid ethyl ester synthas ...
Rattus norvegicus
J. Biol. Chem.
267
23489-23494
1992
-
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1
1
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1
2
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3
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1
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6
2
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8
1
1
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2
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1
1
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1
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646067
Sharma
Independent segregation of glu ...
Homo sapiens
Biochem. J.
275
507-513
1991
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7
1
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1
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1
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646069
Bora
Molecular cloning, sequencing, ...
Homo sapiens
J. Biol. Chem.
266
16774-16777
1991
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1
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2
1
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1
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4
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1
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1
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1
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4
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3
1
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1
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-
646066
Riley
Pancreatic cholesterol esteras ...
Homo sapiens
Biochemistry
29
3848-3852
1990
1
-
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1
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1
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2
1
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3
-
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1
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2
1
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10
1
1
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1
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1
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-
-
-
-
-
1
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1
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2
1
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1
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2
1
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10
1
1
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1
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646065
Bora
Purification to homogeneity an ...
Homo sapiens
FEBS Lett.
258
236-239
1989
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5
2
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2
1
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2
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3
2
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7
1
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1
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5
2
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2
1
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1
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3
2
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7
1
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1
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646062
Mogelson
Nonoxidative ethanol metabolis ...
Oryctolagus cuniculus
Biochemistry
23
4075-4081
1984
-
-
-
-
-
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3
9
1
-
2
2
-
1
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1
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-
2
2
-
12
1
1
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-
1
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-
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-
-
-
-
-
-
-
-
-
3
-
9
1
-
2
2
-
-
-
1
-
2
2
-
12
1
1
-
-
-
1
-
-
-
-
-
-
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-
646063
Mogelson
Partial purification and produ ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
798
144-148
1984
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-
-
-
-
-
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2
2
-
-
1
-
1
-
-
1
-
-
2
-
-
3
-
1
-
-
-
1
-
-
-
-
-
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-
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-
-
-
-
-
-
2
2
-
-
1
-
-
-
1
-
2
-
-
3
-
1
-
-
-
1
-
-
-
-
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-
646064
Mogelson
Thermodynamic bases for fatty ...
Oryctolagus cuniculus
Biochemistry
23
4082-4087
1984
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1
1
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1
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1
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2
2
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2
-
1
-
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3
1
-
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-
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-
1
1
-
-
-
-
-
-
1
-
2
2
-
2
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1
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3
1
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