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Literature summary for 3.1.1.25 extracted from

  • Gaidukov, L.; Tawfik, D.S.
    High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I (2005), Biochemistry, 44, 11843-11854.
    View publication on PubMed
Search for more literature for 3.1.1.25

Activating Compound

Activating Compound Comment Organism Structure
apolipoprotein apoA-I only apolipoprotein apoA-I is capable of stimulating the lactonase activity, while apoA-IV and apoA-II have almost no effect Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.3
-
 gamma-dodecanoic lactone pH 8.3, activity buffer with 0.01 mM apolipoprotein apoA-I rHDL Homo sapiens
0.5
-
 delta-valerolactone pH 8.3, activity buffer with 0.01 mM apolipoprotein apoA-I rHDL Homo sapiens
0.7
-
 gamma-dodecanoic lactone pH 8.3, activity buffer with 0.1% tergitol Homo sapiens
0.9
-
 delta-valerolactone pH 8.3, activity buffer with 0.1% tergitol Homo sapiens
1
-
 delta-valerolactone pH 8.3, activity buffer Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27169
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
delta-valerolactone + H2O
-
 Homo sapiens 5-hydroxypentanoic acid
-
 ?
gamma-dodecanoic lactone + H2O
-
 Homo sapiens 4-hydroxydodecanoic acid
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
34
-
 gamma-dodecanoic lactone pH 8.3, activity buffer with 0.1% tergitol Homo sapiens
94
-
 delta-valerolactone pH 8.3, activity buffer Homo sapiens
101
-
 gamma-dodecanoic lactone pH 8.3, activity buffer with 0.01 mM apolipoprotein apoA-I rHDL Homo sapiens
156
-
 delta-valerolactone pH 8.3, activity buffer with 0.1% tergitol Homo sapiens
632
-
 delta-valerolactone pH 8.3, activity buffer with 0.01 mM apolipoprotein apoA-I rHDL Homo sapiens