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Literature summary for 3.1.1.13 extracted from

  • Sakai, K.; Igarashi, M.; Yamamuro, D.; Ohshiro, T.; Nagashima, S.; Takahashi, M.; Enkhtuvshin, B.; Sekiya, M.; Okazak, H.; Osuga, J.I.; Ishibashi, S.
    Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages (2014), J. Lipid Res., 55, 2033-2040.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.13

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293A cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
(+)-AS115 non-selective inhibitor Mus musculus
(-)-AS115 non-selective inhibitor Mus musculus
76-0079
-
 Mus musculus
additional information not inhibited by orlistat and benzil Mus musculus
paraoxon selective inhibitor Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 x * 50000, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q8BLF1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
peritoneal macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesteryl oleate + H2O
-
 Mus musculus cholesterol + oleic acid
-
 ?

Subunits

Subunits Comment Organism
? x * 50000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
NCEH
-
 Mus musculus
Nceh1
-
 Mus musculus
neutral CE hydrolase 1
-
 Mus musculus
neutral cholesteryl ester hydrolase 1
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000003
-
 pH and temperature not specified in the publication Mus musculus paraoxon
0.0001
-
 pH and temperature not specified in the publication Mus musculus (-)-AS115
0.0003
-
 pH and temperature not specified in the publication Mus musculus (+)-AS115
0.0023
-
 pH and temperature not specified in the publication Mus musculus 76-0079

Expression

Organism Comment Expression
Mus musculus enzyme activity is not increased by overexpression of Ces3 additional information
Mus musculus enzyme activity is increased 24.9fold by overexpression of hormone-sensitive lipase up

General Information

General Information Comment Organism
physiological function the enzyme plays a dominant role over hormone-sensitive lipase in the hydrolysis of cholesteryl ester and subsequent cholesterol efflux in mouse peritoneal macrophages Mus musculus