Literature summary for 3.1.1.13 extracted from

Yan, C.; Lian, X.; Li, Y.; Dai, Y.; White, A.; Qin, Y.; Li, H.; Hume, D.A.; Du, H.
Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal-/- mice (2006), Am. J. Pathol., 169, 916-926.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in lal-/- mice and macrophages	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	doxycycline-induced enzyme expression in macrophages significantly ameliorates aberrant gene expression, inflamatory cell influx, and pathogenesis in multiple organs of transgenic enzyme-deficient mice	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	neutral lipid metabolism in macrophages contributes to organ inflammation and pathogenesis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	neutral lipid metabolism in macrophages contributes to organ inflammation and pathogenesis	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
LAL	-	Homo sapiens
lysosomal acid lipase	-	Homo sapiens

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Release 2023.1 (January 2023)