Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.103 extracted from

  • Qamar, A.; Golemi-Kotra, D.
    Dual roles of FmtA in Staphylococcus aureus cell wall biosynthesis and autolysis (2012), Antimicrob. Agents Chemother., 56, 3797-3805 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.103

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Staphylococcus aureus

Protein Variants

Protein Variants Comment Organism
S127A the mutant show strongly reduced activity and no DD-carboxypeptidase activity compared to the wild type enzyme Staphylococcus aureus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell wall
-
 Staphylococcus aureus 5618
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + H2O Staphylococcus aureus
-
 [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + D-alanine
-
 ?
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + H2O Staphylococcus aureus RN4220
-
 [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + D-alanine
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus RN4220
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-Ala + H2O
-
 Staphylococcus aureus Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala + D-Ala
-
 ?
Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-Ala + H2O
-
 Staphylococcus aureus RN4220 Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala + D-Ala
-
 ?
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + H2O
-
 Staphylococcus aureus [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + D-alanine
-
 ?
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + H2O
-
 Staphylococcus aureus RN4220 [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + D-alanine
-
 ?

Synonyms

Synonyms Comment Organism
fmtA
-
 Staphylococcus aureus

General Information

General Information Comment Organism
physiological function the enzyme has weak D-Ala-D-Ala-carboxypeptidase activity and is capable of covalently incorporating C14-Gly into cell walls Staphylococcus aureus