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Literature summary for 2.8.2.5 extracted from
- Chondroitin 4-O-sulfotransferase-1 regulates E disaccharide expression of chondroitin sulfate required for Herpes simplex virus infectivity (2006), J. Biol. Chem., 281, 38668-38674.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of C4ST-1 in enzyme-deficient sog9 cells | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | CS-deficient sog9 cells, derived from gro2C cells partially resistant to HSV-1 infection and defective in the expression of heparan sulfate because of a splice site mutation in the EXT1 gene encoding the HS-synthesizing enzyme, have a defect in the expression of C4ST-1 in addition to EXT1, decrease in the amount of chondroitin sulfate in sog9 cells is the result of a reduction in the length of chondroitin sulfate chains, glycosyltransferases participating in the biosynthesis of chondroitin sulfate are not affected in sog9 cells, rescue of sog9 cells only by introducing C4ST-1 | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | the enzyme regulates E disaccharide expression of chondroitin sulfate required for Herpes simplex virus infectivity in mouse cells, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme regulates E disaccharide expression of chondroitin sulfate required for Herpes simplex virus infectivity in mouse cells, overview | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| chondroitin 4-O-sulfotransferase-1 | - |
Mus musculus |
| More | the enzyme belongs to the chondroitin/dermatan 4-O-sulfotransferase, C4ST/D4ST, family | Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
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