Any feedback?
Information on EC 2.8.2.5 - chondroitin 4-sulfotransferase
for references in articles please use BRENDA:EC2.8.2.5Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
2.8.2.5 chondroitin 4-sulfotransferaseIUBMB Comments
The sulfation takes place at the 4-position of N-acetyl-galactosamine residues of chondroitin. Not identical with EC 2.8.2.17 chondroitin 6-sulfotransferase.
Specify your search results
Word Map
- 2.8.2.5
- proteoglycans
- glycosaminoglycans
-
sulfotransferases
- keratan
- n-acetylgalactosamine
- 4-sulfate
-
chst15
-
4-o-sulfation
-
6-sulfotransferase
-
uronyl
-
2-o-sulfotransferase
-
iduronic
- medicine
- synthesis
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
c4st-1, chst11, carbohydrate sulfotransferase, c4st, chondroitin 4-sulfotransferase, c4st-2, chondroitin 4-o-sulfotransferase-1, chondroitin-4-sulfotransferase, chondroitin 4-o-sulfotransferase, chondroitin sulfotransferase, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
C41C4.1
C4ST
C4ST-1
C4ST-2
carbohydrate sulfotransferase
Chn 4-O-sulfotransferase
chondroitin 4-O-sulfotransferase
chondroitin 4-O-sulfotransferase-1
chondroitin 4-O-sulfotransferase-2
chondroitin 4-sulfotransferase 1
chondroitin 4-sulfotransferase 2
chondroitin sulfotransferase
-
-
-
-
chondroitin-4-sulfotransferase
chst-1
CHST11
CS-sulfotransferase
sulfotransferase, chondroitin
-
-
-
-
sulfotransferase, chondroitin 4-
-
-
-
-
additional information
-
the enzyme belongs to the chondroitin/dermatan 4-O-sulfotransferase, C4ST/D4ST, family
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
sulfate group transfer
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase
The sulfation takes place at the 4-position of N-acetyl-galactosamine residues of chondroitin. Not identical with EC 2.8.2.17 chondroitin 6-sulfotransferase.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
83589-04-2
-
9026-07-7
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
3'-phosphoadenylylsulfate + chondroitin sulfate C
adenosine 3',5'-bisphosphate + chondroitin sulfate C 4'-sulfate
3'-phosphoadenylylsulfate + chondroitin sulfate D
adenosine 3',5'-bisphosphate + chondroitin sulfate D 4'-sulfate
low activity
-
-
?
3'-phosphoadenylylsulfate + chondroitin-derived oligosaccharides
adenosine 3',5'-bisphosphate + mixture of 4'-monosulfated oligosaccharides
3'-phosphoadenylylsulfate + desulfated chondroitin sulfate A
adenosine 3',5'-bisphosphate + chondroitin sulfate A
3'-phosphoadenylylsulfate + desulfated chondroitin sulfate B
adenosine 3',5'-bisphosphate + chondroitin sulfate B
low activity
-
-
?
3'-phosphoadenylylsulfate + desulfated dermatan sulfate
adenosine 3',5'-bisphosphate + ?
-
113% of the activity with chondroitin
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
recombinant C4ST-1 shows a substrate preference for chondroitin and catalysed the 4-O-sulfation of GalNAc residues
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
the enzyme is involved in the biosynthesis of dermatan sulfate in addition to chondroitin sulfate intermediates
-
-
?
3'-phosphoadenylyl sulfate + dermatan
adenosine 3',5'-bisphosphate + dermatan 4'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + dermatan
adenosine 3',5'-bisphosphate + dermatan 4'-sulfate
-
the enzyme is involved in the biosynthesis of dermatan sulfate in addition to chondroitin sulfate intermediates
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
involved in biosynthesis of chondroitin sulfate
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
isozyme C4ST1, best substrate
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + chondroitin sulfate C
adenosine 3',5'-bisphosphate + chondroitin sulfate C 4'-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + chondroitin sulfate C
adenosine 3',5'-bisphosphate + chondroitin sulfate C 4'-sulfate
low activity
-
-
?
3'-phosphoadenylylsulfate + chondroitin sulfate C
adenosine 3',5'-bisphosphate + chondroitin sulfate C 4'-sulfate
-
low activity
-
-
?
3'-phosphoadenylylsulfate + chondroitin-derived oligosaccharides
adenosine 3',5'-bisphosphate + mixture of 4'-monosulfated oligosaccharides
-
-
-
?
3'-phosphoadenylylsulfate + chondroitin-derived oligosaccharides
adenosine 3',5'-bisphosphate + mixture of 4'-monosulfated oligosaccharides
-
-
-
-
?
3'-phosphoadenylylsulfate + desulfated chondroitin sulfate A
adenosine 3',5'-bisphosphate + chondroitin sulfate A
-
-
-
?
3'-phosphoadenylylsulfate + desulfated chondroitin sulfate A
adenosine 3',5'-bisphosphate + chondroitin sulfate A
low activity
-
-
?
3'-phosphoadenylylsulfate + desulfated chondroitin sulfate A
adenosine 3',5'-bisphosphate + chondroitin sulfate A
-
low activity
-
-
?
3'-phosphoadenylylsulfate + desulfated dermatan sulfate
?
-
-
-
?
3'-phosphoadenylylsulfate + desulfated dermatan sulfate
?
i.e. dermatan
-
-
?
3'-phosphoadenylylsulfate + partially desulfated dermatan sulfate
?
-
-
-
?
3'-phosphoadenylylsulfate + partially desulfated dermatan sulfate
?
isozyme C4ST2, best substrate
-
-
?
3'-phosphoadenylylsulfate + partially desulfated dermatan sulfate
?
isozyme C4ST3, very low activity
-
-
?
additional information
?
-
C4ST-1 also shows activity with partially desulfated dermatan sulfate, strong preference of zebrafish C4ST-1 for the sequence -GlcA-GalNAc(4S)-GlcA- over -IdoA-GalNAc(4S)-IdoA-
-
-
?
additional information
?
-
C4ST-1 also shows activity with partially desulfated dermatan sulfate, strong preference of zebrafish C4ST-1 for the sequence -GlcA-GalNAc(4S)-GlcA- over -IdoA-GalNAc(4S)-IdoA-
-
-
?
additional information
?
-
-
C4ST-1 also shows activity with partially desulfated dermatan sulfate, strong preference of zebrafish C4ST-1 for the sequence -GlcA-GalNAc(4S)-GlcA- over -IdoA-GalNAc(4S)-IdoA-
-
-
?
additional information
?
-
C4ST-2 also shows activity with partially desulfated dermatan sulfate
-
-
?
additional information
?
-
C4ST-2 also shows activity with partially desulfated dermatan sulfate
-
-
?
additional information
?
-
-
C4ST-2 also shows activity with partially desulfated dermatan sulfate
-
-
?
additional information
?
-
no activity with dermatan sulfate, keratan sulfate
-
-
?
additional information
?
-
no activity with dermatan sulfate, keratan sulfate
-
-
?
additional information
?
-
-
no activity with dermatan sulfate, keratan sulfate
-
-
?
additional information
?
-
no activity with desulfated and N-sulfated heparin, and desulfated and N-acetylated heparin
-
-
?
additional information
?
-
no activity with desulfated and N-sulfated heparin, and desulfated and N-acetylated heparin
-
-
?
additional information
?
-
-
no activity with desulfated and N-sulfated heparin, and desulfated and N-acetylated heparin
-
-
?
additional information
?
-
-
no substrate: chondroitin sulfate A, chondroitin sulfate C, dermatan sulfate. Enzyme mainly transfers sulfate to position 4 of the GalNAc residue located at the GlcA-GalNAc-GlcA sequence
-
-
?
additional information
?
-
-
enzyme is required for proper chondroitin sulfate localization, modulation of distinct signaling pathways and cartilage growth plate morphogenesis
-
-
?
additional information
?
-
-
the enzyme regulates E disaccharide expression of chondroitin sulfate required for Herpes simplex virus infectivity in mouse cells, overview
-
-
?
additional information
?
-
-
chondroitin 4-sulfotransferase-1 and -2, which catalyze the 4-O-sulfation of nonsulfated GalNAc residues
-
-
?
additional information
?
-
-
chondroitin 4-sulfotransferase-1 and -2, which catalyze the 4-O-sulfation of nonsulfated GalNAc residues
-
-
?
additional information
?
-
-
no activity with dermatan sulfate, keratan sulfate
-
-
?
additional information
?
-
-
chondroitin sulfate E, heparan sulfate, and completely desulfated N-resulfated heparin are no acceptor substrates
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
3'-phosphoadenylyl sulfate + dermatan
adenosine 3',5'-bisphosphate + dermatan 4'-sulfate
-
the enzyme is involved in the biosynthesis of dermatan sulfate in addition to chondroitin sulfate intermediates
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
the enzyme is involved in the biosynthesis of dermatan sulfate in addition to chondroitin sulfate intermediates
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
involved in biosynthesis of chondroitin sulfate
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + chondroitin
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
-
-
?
additional information
?
-
-
enzyme is required for proper chondroitin sulfate localization, modulation of distinct signaling pathways and cartilage growth plate morphogenesis
-
-
?
additional information
?
-
-
the enzyme regulates E disaccharide expression of chondroitin sulfate required for Herpes simplex virus infectivity in mouse cells, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
Mn2+
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Detergents
-
with the exception of Triton X-100 and Nonidet P-40, inhibit sulfation in the mast cell system
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
stimulation by basic substances is much higher than that by Mn2+, however increasing Mn2+ concentration immediately reduces the stimulation by basic substances
-
protamine
-
molar ratio of protamine to repeating disaccharide unit of chondroitin is 1:100
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase.
Adenocarcinoma
Prognostic impact of carbohydrate sulfotransferase 15 in patients with pancreatic ductal adenocarcinoma.
Atherosclerosis
Correlation of C4ST-1 and ChGn-2 expression with chondroitin sulfate chain elongation in atherosclerosis.
Brain Injuries, Traumatic
Decline in arylsulfatase B and Increase in chondroitin 4-sulfotransferase combine to increase chondroitin 4-sulfate in traumatic brain injury.
Breast Neoplasms
Carbohydrate (Chondroitin 4) Sulfotransferase-11-Mediated Induction of Epithelial-Mesenchymal Transition and Generation of Cancer Stem Cells.
Breast Neoplasms
Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11 gene expression in forming surface P-selectin ligands in aggressive breast cancer cells.
Breast Neoplasms
Cleavage of Syndecan-1 Promotes the Proliferation of the Basal-Like Breast Cancer Cell Line BT-549 Via Akt SUMOylation.
Breast Neoplasms
Long noncoding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15.
Carcinoma, Hepatocellular
Carbohydrate Sulfotransferase 4 Inhibits the Progression of Hepatitis B Virus-Related Hepatocellular Carcinoma and Is a Potential Prognostic Marker in Several Tumors.
Cardiomyopathy, Dilated
Small interfering RNA therapy against carbohydrate sulfotransferase 15 inhibits cardiac remodeling in rats with dilated cardiomyopathy.
chondroitin 4-sulfotransferase deficiency
Inherited CHST11/MIR3922 deletion is associated with a novel recessive syndrome presenting with skeletal malformation and malignant lymphoproliferative disease.
Chondrosarcoma
Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues.
Chondrosarcoma
N-linked oligosaccharides are required to produce and stabilize the active form of chondroitin 4-sulphotransferase-1.
Chondrosarcoma
Purification and characterization of chondroitin 4-sulfotransferase from the culture medium of a rat chondrosarcoma cell line.
Colitis
Pivotal Role of Carbohydrate Sulfotransferase 15 in Fibrosis and Mucosal Healing in Mouse Colitis.
Corneal Dystrophies, Hereditary
Different mutations in carbohydrate sulfotransferase 6 (CHST6) gene cause macular corneal dystrophy types I and II in a single sibship.
Corneal Dystrophies, Hereditary
Identification of novel mutations in the carbohydrate sulfotransferase gene (CHST6) causing macular corneal dystrophy.
Corneal Dystrophies, Hereditary
Impairment of the autophagy-lysosomal pathway and activation of pyroptosis in macular corneal dystrophy.
Corneal Dystrophies, Hereditary
In vivo laser confocal microscopic findings of corneal stromal dystrophies.
Corneal Dystrophies, Hereditary
Localization and expression of CHST6 and keratan sulfate proteoglycans in the human cornea.
Corneal Dystrophies, Hereditary
Macular corneal dystrophy in a Chinese family related with novel mutations of CHST6.
Corneal Dystrophies, Hereditary
Mutation analysis of CHST6 gene in Chinese patients with macular corneal dystrophy.
Corneal Dystrophies, Hereditary
Mutation analysis of the carbohydrate sulfotransferase gene in Vietnamese with macular corneal dystrophy.
Corneal Dystrophies, Hereditary
Mutations in corneal carbohydrate sulfotransferase 6 gene (CHST6) cause macular corneal dystrophy in Iceland.
Corneal Dystrophies, Hereditary
Novel CHST6 Gene Mutations in 2 Unrelated Cases of Macular Corneal Dystrophy.
Corneal Dystrophies, Hereditary
Novel CHST6 nonsense and missense mutations responsible for macular corneal dystrophy.
Corneal Dystrophies, Hereditary
Novel compound heterozygous mutations in the CHST6 gene cause macular corneal dystrophy in a Han Chinese family.
Corneal Dystrophies, Hereditary
Novel mutations in the carbohydrate sulfotransferase gene (CHST6) in American patients with macular corneal dystrophy.
Corneal Dystrophies, Hereditary
Novel mutations in the CHST6 gene associated with macular corneal dystrophy in southern India.
Corneal Dystrophies, Hereditary
Novel mutations in the CHST6 gene causing macular corneal dystrophy.