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Literature summary for 2.8.2.30 extracted from

  • Vanpouille, C.; Deligny, A.; Delehedde, M.; Denys, A.; Melchior, A.; Lienard, X.; Lyon, M.; Mazurier, J.; Fernig, D.G.; Allain, F.
    The heparin/heparan sulfate sequence that interacts with cyclophilin B contains a 3-O-sulfated N-unsubstituted glucosamine residue (2007), J. Biol. Chem., 282, 24416-24429.
    View publication on PubMed
Search for more literature for 2.8.2.30

Protein Variants

Protein Variants Comment Organism
additional information a synthetic siRNA duplex, si3-OST-3, corresponding to 3-OST-3 mRNA sequences is used to inhibit the expression of mRNAs encoding 3-OST-3 isoforms, downregulation of the expression of 3-OST-3 by RNA interference potently reduced CyPB binding and consequent activation of p44/42 mitogen-activated protein kinases, overview Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information cyclosporine B heparin binding kinetics, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine Homo sapiens 3-O-sulfation of GlcNH2-containing heparan sulfate by 3-OST-3 provides binding sites for glycoprotein gD of Herpes simplex virus type I and is involved in involved in cyclosporine B, CyPB, binding and viral infection, analysis of heparin sulfate structures involve, overview adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell clone E6-1,expresssion of 3-OST-3B isoform Homo sapiens
-
T-lymphocyte of peripheral blood, expresssion of 3-OST-3B isoform Homo sapiens
-
THP-1 cell promonocytic leukemia cells Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 p44/42 MAPK activation, semi-quantitative expression analysis by RT-PCR, determination of unmodified heparin and cell surface binding, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine 3-O-sulfation of GlcNH2-containing heparan sulfate by 3-OST-3 provides binding sites for glycoprotein gD of Herpes simplex virus type I and is involved in involved in cyclosporine B, CyPB, binding and viral infection, analysis of heparin sulfate structures involve, overview Homo sapiens adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine C5 epimerization of some GlcUA into L-iduronic acid, IdoUA, 2-O-sulfation of IdoUA, and 6-O-sulfation of GlcN units Homo sapiens adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
3-O-sulfotransferase-3
-
 Homo sapiens
3-OST-3
-
 Homo sapiens