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Literature summary for 2.8.2.21 extracted from

  • Patnode, M.L.; Yu, S.Y.; Cheng, C.W.; Ho, M.Y.; Tegesjoe, L.; Sakuma, K.; Uchimura, K.; Khoo, K.H.; Kannagi, R.; Rosen, S.D.
    KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing (2013), Glycobiology, 23, 381-394.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + keratan Mus musculus
-
 adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymph node expressed in high endothelial venules of lymph nodes Mus musculus
-
Peyer's patch expressed in high endothelial venules of Peyer's patches Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + keratan
-
 Mus musculus adenosine 3',5'-bisphosphate + keratan 6'-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
keratan sulfate galactose 6-O-sulfotransferase
-
 Mus musculus
KSGal6ST
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme knockout mice do not exhibit a detectable deficiency in short-term lymphocyte homing Mus musculus
metabolism the enzyme is required for the generation of Siaalpha2->3[6S]beta->4[6S]GlcNAc or a closely related structure in lymph node high endothelial venules. The enzyme does does not contribute to L-selectin ligand expression or lymphocyte homing Mus musculus