Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-hydroxytamoxifen | noncompetitive inhibition | Homo sapiens | |
endoxifen | i.e. 4-hydroxy-N-desmethyltamoxifen, potent noncompetitive inhibition | Homo sapiens | |
N-demethyltamoxifen | competitive inhibition | Homo sapiens | |
tamoxifen N-oxide | noncompetitive inhibition | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + dehydroepiandrosterone | Homo sapiens | - |
adenosine 3',5'-bisphosphate + dehydroepiandrosterone sulfate | - |
? | |
3'-phosphoadenylyl sulfate + pregnenolone | Homo sapiens | - |
adenosine 3',5'-bisphosphate + pregnenolone sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q06520 | - |
- |
Purification (Comment) | Organism |
---|---|
DE-52 column chromatography and hydroxyapatite column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + dehydroepiandrosterone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + dehydroepiandrosterone sulfate | - |
? | |
3'-phosphoadenylyl sulfate + pregnenolone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + pregnenolone sulfate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
human hydroxysteroid sulfotransferase 2A1 | - |
Homo sapiens |
SULT2A1 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0028 | - |
endoxifen | with dehydroepiandrosterone as substrate, at pH 7.4 and 37°C | Homo sapiens | |
0.0035 | - |
endoxifen | with pregnenolone as substrate, at pH 7.4 and 37°C | Homo sapiens | |
0.0096 | - |
tamoxifen N-oxide | with dehydroepiandrosterone as substrate, at pH 7.4 and 37°C | Homo sapiens | |
0.0098 | - |
N-demethyltamoxifen | with pregnenolone as substrate, at pH 7.4 and 37°C | Homo sapiens | |
0.0127 | - |
4-hydroxytamoxifen | with pregnenolone as substrate, at pH 7.4 and 37°C | Homo sapiens | |
0.0169 | - |
tamoxifen N-oxide | with pregnenolone as substrate, at pH 7.4 and 37°C | Homo sapiens | |
0.0172 | - |
N-demethyltamoxifen | with dehydroepiandrosterone as substrate, at pH 7.4 and 37°C | Homo sapiens | |
0.0194 | - |
4-hydroxytamoxifen | with dehydroepiandrosterone as substrate, at pH 7.4 and 37°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0017 | - |
with dehydroepiandrosterone as substrate, at pH 7.4 and 37°C | Homo sapiens | endoxifen | |
0.0027 | - |
with pregnenolone as substrate, at pH 7.4 and 37°C | Homo sapiens | endoxifen | |
0.0083 | - |
with dehydroepiandrosterone as substrate, at pH 7.4 and 37°C | Homo sapiens | N-demethyltamoxifen | |
0.01 | - |
with dehydroepiandrosterone as substrate, at pH 7.4 and 37°C | Homo sapiens | 4-hydroxytamoxifen | |
0.0111 | - |
with dehydroepiandrosterone as substrate, at pH 7.4 and 37°C | Homo sapiens | tamoxifen N-oxide | |
0.015 | - |
with pregnenolone as substrate, at pH 7.4 and 37°C | Homo sapiens | N-demethyltamoxifen | |
0.0161 | - |
with pregnenolone as substrate, at pH 7.4 and 37°C | Homo sapiens | tamoxifen N-oxide | |
0.0167 | - |
with pregnenolone as substrate, at pH 7.4 and 37°C | Homo sapiens | 4-hydroxytamoxifen |