Cloned (Comment) | Organism |
---|---|
expression of SULT1A2 in Escherichia coli strain BL21 (DE3) | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4'-hydroxy-2,5-dichlorobiphenyl | i.e. 4'-OH PCB 9, inhibition of SULT1A2 | Homo sapiens | |
4-hydroxy-2',3,5-trichlorobiphenyl | i.e. 4-OH PCB 34, substrate inhibition of SULT1A2 | Homo sapiens | |
dehydroepiandrosterone | i.e. DHEA, substrate inhibition of SULT1A2 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | for 4'-OH PCB 68, the limit of solubility makes the determination of kinetic constants difficult, the highest rate of sulfation is observed at the limit of solubility at about 0.05 mM | Homo sapiens | |
0.025 | - |
dehydroepiandrosterone | pH 7.0, 37°C, recombinant SULT1A2 | Homo sapiens | |
0.046 | - |
4-hydroxy-2',3,5-trichlorobiphenyl | pH 7.0, 37°C, recombinant SULT1A2 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + dehydroepiandrosterone | Homo sapiens | - |
adenosine 3',5'-bisphosphate + dehydroepiandrosterone O-sulfate | - |
? | |
additional information | Homo sapiens | hydroxylated polychlorinated biphenyls may compete with other xenobiotic substrates as well as endogenous substrates for SULT2A1 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
SULT2A1 | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0175 | - |
purified recombinant SULT1A2, substrate 4'-hydroxy-2,3',4,5'-tetrachlorobiphenyl | Homo sapiens |
0.027 | - |
purified recombinant SULT1A2, substrate 4-hydroxy-2',3,5-trichlorobiphenyl | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + 4'-hydroxy-2,3',4,5'-tetrachlorobiphenyl | i.e. 4'-OH PCB 68, substrate of SULT1A2 | Homo sapiens | adenosine 3',5'-bisphosphate + 4'-hydroxy-2,3',4,5'-tetrachlorobiphenyl 4'-O-sulfate | - |
? | |
3'-phosphoadenylyl sulfate + 4-hydroxy-2',3,5-trichlorobiphenyl | i.e. 4-OH PCB 34, substrate of SULT1A2 | Homo sapiens | adenosine 3',5'-bisphosphate + 2',3,5-trichlorobiphenyl-4-yl hydrogen sulfate | - |
? | |
3'-phosphoadenylyl sulfate + dehydroepiandrosterone | i.e. DHEA, substrate of SULT1A2 | Homo sapiens | adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate | - |
? | |
3'-phosphoadenylyl sulfate + dehydroepiandrosterone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + dehydroepiandrosterone O-sulfate | - |
? | |
additional information | hydroxylated polychlorinated biphenyls may compete with other xenobiotic substrates as well as endogenous substrates for SULT2A1 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DHEA-ST | - |
Homo sapiens |
hydroxysteroid sulfotransferase | - |
Homo sapiens |
More | SULT2A1 belongs to the family of phenol sulfotransferases | Homo sapiens |
ST2A3 | - |
Homo sapiens |
SULT2A1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.112 | - |
dehydroepiandrosterone | pH 7.0, 37°C, recombinant SULT1A2 | Homo sapiens | |
0.253 | - |
4-hydroxy-2',3,5-trichlorobiphenyl | pH 7.0, 37°C, recombinant SULT1A2 | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0039 | - |
pH 7.0, 37°C, recombinant SULT1A2 | Homo sapiens | 4'-hydroxy-2,5-dichlorobiphenyl |