Application | Comment | Organism |
---|---|---|
medicine | colon cancer cells exposed to N-acetylcysteine for 24 h display increased expression and activity of MST and sulfide:quinone oxidoreductase. N-acetylcysteine persists at detectable levels inside the cells exposed to the drug for up to 24 h and sustains H2S synthesis by MST more effectively than cysteine | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
6 | - |
L-cysteine | pH 8.0, 37°C | Homo sapiens | |
11.4 | - |
N-acetyl-L-cysteine | pH 8.0, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | partly | Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P25325 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
SW-480 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxo-3-sulfanylpropanoate + [3-mercaptopyruvate sulfurtransferase]-L-cysteine | - |
Homo sapiens | pyruvate + [3-mercaptopyruvate sulfurtransferase]-S-sulfanyl-L-cysteine | - |
? | |
7-azido-4-methylcoumarin + L-cysteine | - |
Homo sapiens | ? | - |
? | |
7-azido-4-methylcoumarin + N-acetyl-L-cysteine | - |
Homo sapiens | ? | - |
? | |
[3-mercaptopyruvate sulfurtransferase]-S-sulfanyl-L-cysteine + reduced thioredoxin | - |
Homo sapiens | hydrogen sulfide + [3-mercaptopyruvate sulfurtransferase]-L-cysteine + oxidized thioredoxin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MPST | - |
Homo sapiens |
MST | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | N-acetylcysteine, presence for 24 h, about 60% increase in expression | up |