Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.8 extracted from

  • Fan, Z.; Chen, H.; Li, M.; Pan, X.; Fu, W.; Ren, H.; Chen, R.; Bai, F.; Jin, Y.; Cheng, Z.; Jin, S.; Wu, W.
    Pseudomonas aeruginosa polynucleotide phosphorylase contributes to ciprofloxacin resistance by regulating PrtR (2019), Front. Microbiol., 10, 1762 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.8

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa Q9HV59
-
-

General Information

General Information Comment Organism
physiological function mutation of the polynucleotide phosphorylase coding gene pnp increases the bacterial resistance to ciprofloxacin.The expression of pyocin biosynthesis genes is decreased in the pnp mutant. PrtR, a negative regulator of pyocin biosynthesis genes, is upregulated in the pnp mutant. Polynucleotide phosphorylase represses the expression of PrtR on the posttranscriptional level. A fragment containing 43 nucleotides of the 5' untranslated region is involved in the polynucleotide phosphorylase mediated regulation of PrtR Pseudomonas aeruginosa