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Literature summary for 2.7.7.8 extracted from

  • Fan, Z.; Pan, X.; Wang, D.; Chen, R.; Fu, T.; Yang, B.; Jin, Y.; Bai, F.; Cheng, Z.; Wu, W.
    Pseudomonas aeruginosa polynucleotide phosphorylase controls tolerance to aminoglycoside antibiotics by regulating the MexXY multidrug efflux pump (2020), Antimicrob. Agents Chemother., 65, e01846 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa Q9HV59
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General Information

General Information Comment Organism
physiological function mutation of the polynucleotide phosphorylase encoding gene increases bacterial tolerance to aminoglycoside antibiotics. The upregulation of the multidrug efflux pump MexXY genes is responsible for the increased tolerance of the polynucleotide phosphorylase mutant. Polynucleotide phosphorylase controls the translation of the armZ mRNA, which regulates the expression of MexXY through its 59 untranslated region Pseudomonas aeruginosa