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Literature summary for 2.7.7.49 extracted from

  • Lenzi, G.M.; Domaoal, R.A.; Kim, D.H.; Schinazi, R.F.; Kim, B.
    Mechanistic and kinetic differences between reverse transcriptases of Vpx coding and non-coding lentiviruses (2015), J. Biol. Chem., 290, 30078-30086.
    View publication on PubMedView publication on EuropePMC
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
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 additional information presteady-state kinetic analysis of reverse transcriptases from lentiviruses coding and noncoding for encoded accessory protein Vpx. At all three sites of the template tested, the two reverse transcriptases of the Vpx noncoding viruses (HIV-1) display higher kpol values than the reverse transcriptases of the Vpx coding HIV-2 and African green monkey SIV, whereas there is no significant difference in the Kd values of these two groups of reverse transcriptases. When employing viral RNA templates that induce reverse transcriptases pausing by their secondary structures, the HIV-1 reverse transcriptases show more efficient DNA synthesis through pause sites than the HIV-2/SIV reverse transcriptases Human immunodeficiency virus 1
additional information
-
 additional information presteady-state kinetic analysis of reverse transcriptases from lentiviruses coding and noncoding for encoded accessory protein Vpx. At all three sites of the template tested, the two reverse transcriptases of the Vpx noncoding viruses (HIV-1) display higher kpol values than the reverse transcriptases of the Vpx coding HIV-2 and African green monkey SIV, whereas there is no significant difference in the Kd values of these two groups of reverse transcriptases. When employing viral RNA templates that induce reverse transcriptases pausing by their secondary structures, the HIV-1 reverse transcriptases show more efficient DNA synthesis through pause sites than the HIV-2/SIV reverse transcriptases Simian immunodeficiency virus
additional information
-
 additional information presteady-state kinetic analysis of reverse transcriptases from lentiviruses coding and noncoding for encoded accessory protein Vpx. At all three sites of the template tested, the two reverse transcriptases of the Vpx noncoding viruses (HIV-1) display higher kpol values than the reverse transcriptases of the Vpx coding HIV-2 and African green monkey SIV, whereas there is no significant difference in the Kd values of these two groups of reverse transcriptases. When employing viral RNA templates that induce reverse transcriptases pausing by their secondary structures, the HIV-1 reverse transcriptases show more efficient DNA synthesis through pause sites than the HIV-2/SIV reverse transcriptases Human immunodeficiency virus 2

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
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Human immunodeficiency virus 2
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Simian immunodeficiency virus
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