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Literature summary for 2.7.7.43 extracted from

  • O Day, E.M.; Idos, G.E.; Hill, C.; Chen, J.W.; Wagner, G.
    Cytidine monophosphate N-acetylneuraminic acid synthetase enhances invasion of human triple-negative breast cancer cells (2018), OncoTargets Ther., 11, 6827-6838 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + N-acylneuraminate Homo sapiens
-
 diphosphate + CMP-N-acylneuraminate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NFW8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BPLER cell
-
 Homo sapiens
-
breast cancer cell
-
 Homo sapiens
-
HMLER cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + N-acylneuraminate
-
 Homo sapiens diphosphate + CMP-N-acylneuraminate
-
 ?

Synonyms

Synonyms Comment Organism
CMAS
-
 Homo sapiens
cytidine monophosphate N-acetylneuraminic acid synthetase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme expression is increased in triple-negative breast cancer up

General Information

General Information Comment Organism
physiological function the enzyme plays an important role in triple-negative breast cancer tumor formation and invasivity Homo sapiens