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4-O-methyl-N-acetylneuraminate + CTP
CMP-4-O-methyl-N-acetylneuraminate + diphosphate
CDP + N-acetylneuraminate
phosphate + CMP-N-acetylneuraminate
CTP + (2S,4S,5R,6R)-6-((1R,2S)-3-azido-1,2-dihydroxy-propyl)-2,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-carboxylic acid
diphosphate + CMP-(2S,4S,5R,6R)-6-((1R,2S)-3-azido-1,2-dihydroxy-propyl)-2,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-carboxylic acid
-
-
-
-
?
CTP + (N-4-O-)diacetylneuraminic acid
diphosphate + CMP-N-4-O-diacetylneuraminate
-
(N-4-O-)diacetylneuraminic acid is 46% effective compared to N-acylneuraminate
-
-
?
CTP + 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid
diphosphate + CMP-2-keto-3-deoxy-D-glycero-D-galacto-nononic acid
CTP + 3-deoxy-D-galacto-2-octulosonic acid
diphosphate + CMP-3-deoxy-D-galacto-2-octulosonic acid
-
-
-
-
?
CTP + 3-deoxy-D-glycero-D-galacto-nononate
diphosphate + CMP-3-deoxy-D-glycero-D-galacto-nononate
CTP + 5-deaminoneuraminate
diphosphate + CMP-5-deaminoneuraminate
-
-
-
?
CTP + 8-O-methyl-N-acetylneuraminate
diphosphate + CMP-(8-O-methyl)-N-acetylneuraminate
-
-
-
-
?
CTP + deaminoneuraminic acid
?
-
-
-
-
?
CTP + N-(N-benzyloxycarbonyl-glycyl)-muramic acid
diphosphate + CMP-N-(N-benzyloxycarbonyl-glycyl)-muramic acid
-
-
-
-
?
CTP + N-acetyl-neuraminate
diphosphate + CMP-N-acetylneuraminate
-
-
-
?
CTP + N-acetyl-neuraminic acid
CMP-Neu5Ac + diphosphate
-
-
-
-
?
CTP + N-acetylmuramic acid
diphosphate + CMP-N-acetylmuramic acid
-
-
-
-
?
CTP + N-acetylneuraminate
diphosphate + CMP-N-acetylneuraminate
CTP + N-acetylneuraminic acid
diphosphate + CMP-N-acetylneuraminic acid
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
CTP + N-acylneuraminate methyl ester
diphosphate + CMP-N-acylneuraminate methyl ester
CTP + N-azidoacetylmuramic acid
diphosphate + CMP-N-azidoacetylmuramic acid
-
-
-
-
?
CTP + N-azidomuramic acid
diphosphate + CMP-N-azidomuramic acid
-
-
-
-
?
CTP + N-glycolneuraminate
diphosphate + CMP-N-glycolneuraminate
CTP + N-glycolylneuraminate
diphosphate + CMP-N-glycolylneuraminate
CTP + N-glycolylneuraminic acid
CMP-N-glycolylneuraminate + diphosphate
CTP + N-hydroxyacetylmuramic acid
diphosphate + CMP-N-hydroxyacetylmuramic acid
-
-
-
-
?
CTP + N-hydroxymuramic acid
diphosphate + CMP-N-hydroxymuramic acid
-
-
-
-
?
CTP + N-methylglycolylneuraminate
diphosphate + CMP-N-methylglycolylneuraminate
-
-
-
-
?
CTP + sialic acid
CMP-sialic acid + diphosphate
CTP + sialic acid
diphosphate + CMP-sialic acid
-
-
-
?
deaminoneuraminic acid + CTP
CMP-KDN + diphosphate
N-glycolylneuraminic acid (Neu5Gc) and deaminoneuraminic acid (KDN) are also substrates
-
-
?
fluoroacetylneuraminate + CTP
diphosphate + CMP-N-fluoroacetylneuraminate
N-acetyl-4-O-acetylneuraminate + CTP
diphosphate + CMP-N-acetyl-4-O-acetylneuraminate
N-acetyl-7(8)-O-acetylneuraminate + CTP
diphosphate + CMP-N-acetyl-7(8)-O-acetylneuraminate
N-acetylneuraminic acid + CTP
CMP-Neu5Ac + diphosphate
N-acetylneuraminic acid + CTP
CMP-NeuAc + diphosphate
N-chloroacetylneuraminate + CTP
diphosphate + CMP-N-chloroacetylneuraminate
N-glycolylneuraminic acid + CTP
CMP-N-glycolylneuraminate + diphosphate
N-glycolylneuraminic acid + CTP
CMP-Neu5Gc + diphosphate
N-glycolylneuraminic acid (Neu5Gc) and deaminoneuraminic acid (KDN) are also substrates
-
-
?
TTP + N-acylneuraminate
diphosphate + TMP-N-acylneuraminate
TTP + N-glycolylneuraminic acid
TMP-N-glycolylneuraminate + diphosphate
UDP + N-acetylneuraminate
phosphate + UMP-N-acetylneuraminate
-
-
-
-
?
UDP + N-acylneuraminate
phosphate + UMP-N-acetylneuraminate
UTP + N-acylneuraminate
diphosphate + UMP-N-acylneuraminate
UTP + N-glycolylneuraminic acid
UMP-N-glycolylneuraminate + diphosphate
-
-
-
-
?
additional information
?
-
4-O-methyl-N-acetylneuraminate + CTP

CMP-4-O-methyl-N-acetylneuraminate + diphosphate
-
-
-
?
4-O-methyl-N-acetylneuraminate + CTP
CMP-4-O-methyl-N-acetylneuraminate + diphosphate
-
no activity
-
-
?
CDP + N-acetylneuraminate

phosphate + CMP-N-acetylneuraminate
-
-
-
-
?
CDP + N-acetylneuraminate
phosphate + CMP-N-acetylneuraminate
-
no activity with CDP
-
-
?
CDP + N-acetylneuraminate
phosphate + CMP-N-acetylneuraminate
-
-
-
-
?
CDP + N-acetylneuraminate
phosphate + CMP-N-acetylneuraminate
-
-
-
-
?
CDP + N-acetylneuraminate
phosphate + CMP-N-acetylneuraminate
-
-
-
-
?
CDP + N-acetylneuraminate
phosphate + CMP-N-acetylneuraminate
-
no activity with CDP
-
-
?
CDP + N-acetylneuraminate
phosphate + CMP-N-acetylneuraminate
-
no activity with CDP
-
-
?
CTP + 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid

diphosphate + CMP-2-keto-3-deoxy-D-glycero-D-galacto-nononic acid
recombinant enzyme shows 15times lower activity towards 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid than towards N-acetylneuraminate
-
-
?
CTP + 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid
diphosphate + CMP-2-keto-3-deoxy-D-glycero-D-galacto-nononic acid
enzyme shows high activity towards 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid and towards N-acetylneuraminate
-
-
?
CTP + 3-deoxy-D-glycero-D-galacto-nononate

diphosphate + CMP-3-deoxy-D-glycero-D-galacto-nononate
-
reaction of EC 2.7.7.92
-
?
CTP + 3-deoxy-D-glycero-D-galacto-nononate
diphosphate + CMP-3-deoxy-D-glycero-D-galacto-nononate
-
reaction of EC 2.7.7.92
-
?
CTP + N-acetylneuraminate

diphosphate + CMP-N-acetylneuraminate
-
-
-
?
CTP + N-acetylneuraminate
diphosphate + CMP-N-acetylneuraminate
-
-
-
-
?
CTP + N-acetylneuraminate
diphosphate + CMP-N-acetylneuraminate
-
-
-
?
CTP + N-acetylneuraminate
diphosphate + CMP-N-acetylneuraminate
-
-
-
-
?
CTP + N-acetylneuraminate
diphosphate + CMP-N-acetylneuraminate
-
-
-
-
?
CTP + N-acetylneuraminate
diphosphate + CMP-N-acetylneuraminate
-
-
-
-
?
CTP + N-acetylneuraminate
diphosphate + CMP-N-acetylneuraminate
-
-
-
-
?
CTP + N-acetylneuraminate
diphosphate + CMP-N-acetylneuraminate
-
-
-
-
?
CTP + N-acetylneuraminic acid

diphosphate + CMP-N-acetylneuraminic acid
-
-
-
?
CTP + N-acetylneuraminic acid
diphosphate + CMP-N-acetylneuraminic acid
the enzyme displays specificity for N-acetylneuraminic acid as a substrate
-
-
?
CTP + N-acetylneuraminic acid
diphosphate + CMP-N-acetylneuraminic acid
-
-
-
?
CTP + N-acetylneuraminic acid
diphosphate + CMP-N-acetylneuraminic acid
-
-
-
?
CTP + N-acylneuraminate

diphosphate + CMP-N-acylneuraminate
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
the product of the reaction CMP-N-acylneuraminate is the substrate for the sialylation of glycoconjugates by sialyltransferases
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
the lec32 mutation reduces CMP-NeuAc synthetase activity to undetectable levels and reduces Neu-Ac on glycoproteins and glycolipids by 95%
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
reaction is theoretically reversible, even though the ratio between the velocities in the anabolic and catabolic direction is 1000:1
-
-
r
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
CMP-NeuAc is essential for the formation of capsule polysialylate for strain K1
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
CMP-NeuAc is essential for the formation of capsule polysialylate for strain K1
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
neuroinvasive and septicaemia-causing pathogens often display a polysialic acid capsule that is involved in invasive behaviour. N-Acetylneuraminate is the basic monomer of polysialic acid. The activated form CMP-N-acylneuraminate is synthesized by N-acylneuraminate cytidylyltransferase
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
neuroinvasive and septicaemia-causing pathogens often display a polysialic acid capsule that is involved in invasive behaviour. N-Acetylneuraminate is the basic monomer of polysialic acid. The activated form CMP-N-acylneuraminate is synthesized by N-acylneuraminate cytidylyltransferase
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
production of CMP-N-acetylneuraminate is required for the synthesis of sialylated glycoconjugates
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
enzyme shows pronounced specificity for N-acylneuraminate
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
ir
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
the enzyme is involved in the production of activated sialic acids
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
enzyme is equally active with either of the three substrates: N-acylneuraminate, N-glycolylneuraminate and deaminoneuraminic acid
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
changes in the level of sialylation during development are intimately related to variations in the expression of the enzyme, at least in brain, heart, kidney, stomach, intestine and lung
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
the enzyme is involved in synthesis of capsular polysaccharide, the recombinant enzyme can function in K1 capsular polysaccharide biosynthesis in Escherichia coli
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
the enzyme is essential in capsular polysaccharide biosynthesis, activates N-acetylneuraminate for transfer to the nascent capsular polysaccharide
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
the enzyme is essential in capsular polysaccharide biosynthesis, activates N-acetylneuraminate for transfer to the nascent capsular polysaccharide
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
r
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
r
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
r
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
reaction is freely reversible and the ratio of the velocities in synthesis and degradation direction is 3:1
-
-
r
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
the enzyme produces CMP-N-acetylneuraminate, the nucleotide sugar donor used by sialyltransferase
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
the enzyme produces CMP-N-acetylneuraminate, the nucleotide sugar donor used by sialyltransferase
-
-
?
CTP + N-acylneuraminate methyl ester

diphosphate + CMP-N-acylneuraminate methyl ester
-
-
-
-
?
CTP + N-acylneuraminate methyl ester
diphosphate + CMP-N-acylneuraminate methyl ester
-
-
-
-
?
CTP + N-glycolneuraminate

diphosphate + CMP-N-glycolneuraminate
relatively inferior substrate
-
-
?
CTP + N-glycolneuraminate
diphosphate + CMP-N-glycolneuraminate
-
N-glycolneuraminate is a relatively weaker substrate than N-acylneuraminate
-
-
?
CTP + N-glycolylneuraminate

diphosphate + CMP-N-glycolylneuraminate
-
-
-
-
?
CTP + N-glycolylneuraminate
diphosphate + CMP-N-glycolylneuraminate
-
-
-
?
CTP + N-glycolylneuraminate
diphosphate + CMP-N-glycolylneuraminate
-
-
-
-
?
CTP + N-glycolylneuraminate
diphosphate + CMP-N-glycolylneuraminate
-
-
-
-
?
CTP + N-glycolylneuraminate
diphosphate + CMP-N-glycolylneuraminate
-
-
-
-
?
CTP + N-glycolylneuraminate
diphosphate + CMP-N-glycolylneuraminate
-
-
-
?
CTP + N-glycolylneuraminate
diphosphate + CMP-N-glycolylneuraminate
-
-
-
?
CTP + N-glycolylneuraminate
diphosphate + CMP-N-glycolylneuraminate
-
-
-
-
?
CTP + N-glycolylneuraminate
diphosphate + CMP-N-glycolylneuraminate
-
-
-
-
?
CTP + N-glycolylneuraminate
diphosphate + CMP-N-glycolylneuraminate
-
-
-
-
?
CTP + N-glycolylneuraminate
diphosphate + CMP-N-glycolylneuraminate
-
-
-
-
?
CTP + N-glycolylneuraminate
diphosphate + CMP-N-glycolylneuraminate
-
-
-
-
?
CTP + N-glycolylneuraminate
diphosphate + CMP-N-glycolylneuraminate
-
-
-
r
CTP + N-glycolylneuraminate
diphosphate + CMP-N-glycolylneuraminate
-
-
-
-
?
CTP + N-glycolylneuraminate
diphosphate + CMP-N-glycolylneuraminate
-
-
-
-
?
CTP + N-glycolylneuraminic acid

CMP-N-glycolylneuraminate + diphosphate
-
-
-
-
?
CTP + N-glycolylneuraminic acid
CMP-N-glycolylneuraminate + diphosphate
-
-
-
-
?
CTP + N-glycolylneuraminic acid
CMP-N-glycolylneuraminate + diphosphate
-
-
-
-
?
CTP + N-glycolylneuraminic acid
CMP-N-glycolylneuraminate + diphosphate
-
-
-
-
?
CTP + N-glycolylneuraminic acid
CMP-N-glycolylneuraminate + diphosphate
-
-
-
-
?
CTP + sialic acid

CMP-sialic acid + diphosphate
-
-
-
?
CTP + sialic acid
CMP-sialic acid + diphosphate
-
-
-
-
?
CTP + sialic acid
CMP-sialic acid + diphosphate
-
-
-
-
?
fluoroacetylneuraminate + CTP

diphosphate + CMP-N-fluoroacetylneuraminate
-
-
-
-
?
fluoroacetylneuraminate + CTP
diphosphate + CMP-N-fluoroacetylneuraminate
-
-
-
-
?
fluoroacetylneuraminate + CTP
diphosphate + CMP-N-fluoroacetylneuraminate
-
-
-
-
?
N-acetyl-4-O-acetylneuraminate + CTP

diphosphate + CMP-N-acetyl-4-O-acetylneuraminate
-
-
-
-
?
N-acetyl-4-O-acetylneuraminate + CTP
diphosphate + CMP-N-acetyl-4-O-acetylneuraminate
-
-
-
-
?
N-acetyl-4-O-acetylneuraminate + CTP
diphosphate + CMP-N-acetyl-4-O-acetylneuraminate
-
-
-
-
?
N-acetyl-7(8)-O-acetylneuraminate + CTP

diphosphate + CMP-N-acetyl-7(8)-O-acetylneuraminate
-
-
-
-
?
N-acetyl-7(8)-O-acetylneuraminate + CTP
diphosphate + CMP-N-acetyl-7(8)-O-acetylneuraminate
-
-
-
-
?
N-acetyl-7(8)-O-acetylneuraminate + CTP
diphosphate + CMP-N-acetyl-7(8)-O-acetylneuraminate
-
-
-
-
?
N-acetylneuraminic acid + CTP

CMP-Neu5Ac + diphosphate
-
DmCSAS is shown to be functional both in vitro and in vivo
-
-
?
N-acetylneuraminic acid + CTP
CMP-Neu5Ac + diphosphate
N-glycolylneuraminic acid (Neu5Gc) and deaminoneuraminic acid (KDN) are also substrates
-
-
?
N-acetylneuraminic acid + CTP

CMP-NeuAc + diphosphate
-
-
-
-
?
N-acetylneuraminic acid + CTP
CMP-NeuAc + diphosphate
-
bi-bi catalytic mechanism, enzyme also accepts N-glycolylneuraminic acid (NeuGc) as a substrate
-
-
?
N-acetylneuraminic acid + CTP
CMP-NeuAc + diphosphate
-
bi-bi catalytic mechanism, enzyme also accepts N-glycolylneuraminic acid (NeuGc) as a substrate
-
-
?
N-chloroacetylneuraminate + CTP

diphosphate + CMP-N-chloroacetylneuraminate
-
-
-
-
?
N-chloroacetylneuraminate + CTP
diphosphate + CMP-N-chloroacetylneuraminate
-
-
-
-
?
N-chloroacetylneuraminate + CTP
diphosphate + CMP-N-chloroacetylneuraminate
-
-
-
-
?
N-glycolylneuraminic acid + CTP

CMP-N-glycolylneuraminate + diphosphate
-
-
-
-
?
N-glycolylneuraminic acid + CTP
CMP-N-glycolylneuraminate + diphosphate
-
-
-
-
?
TTP + N-acylneuraminate

diphosphate + TMP-N-acylneuraminate
-
no activity with TTP
-
-
?
TTP + N-acylneuraminate
diphosphate + TMP-N-acylneuraminate
-
-
-
-
?
TTP + N-acylneuraminate
diphosphate + TMP-N-acylneuraminate
-
-
-
-
?
TTP + N-acylneuraminate
diphosphate + TMP-N-acylneuraminate
-
no activity with TTP
-
-
?
TTP + N-acylneuraminate
diphosphate + TMP-N-acylneuraminate
-
no activity with TTP
-
-
?
TTP + N-glycolylneuraminic acid

TMP-N-glycolylneuraminate + diphosphate
-
-
-
-
?
TTP + N-glycolylneuraminic acid
TMP-N-glycolylneuraminate + diphosphate
-
-
-
-
?
UDP + N-acylneuraminate

phosphate + UMP-N-acetylneuraminate
-
-
-
-
?
UDP + N-acylneuraminate
phosphate + UMP-N-acetylneuraminate
-
-
-
-
?
UTP + N-acylneuraminate

diphosphate + UMP-N-acylneuraminate
-
-
-
-
?
UTP + N-acylneuraminate
diphosphate + UMP-N-acylneuraminate
-
no activity with UTP
-
-
?
UTP + N-acylneuraminate
diphosphate + UMP-N-acylneuraminate
-
-
-
-
?
UTP + N-acylneuraminate
diphosphate + UMP-N-acylneuraminate
-
-
-
-
?
UTP + N-acylneuraminate
diphosphate + UMP-N-acylneuraminate
-
no activity with UTP
-
-
?
UTP + N-acylneuraminate
diphosphate + UMP-N-acylneuraminate
-
no activity with UTP
-
-
?
additional information

?
-
enzyme is strictly dependent on CTP
-
-
?
additional information
?
-
enzyme is strictly dependent on CTP
-
-
?
additional information
?
-
-
enzyme is strictly dependent on CTP
-
-
?
additional information
?
-
ATP, GTP and UTP, along with CDP and CMP cannot be used as substrates. The enzyme has a nearly undetectable activity toward 2-keto-3-deoxynononic acid and 2-keto-3-deoxyoctonic acid while no activity is detected with 3-deoxy-D-manno-2-octulosonic acid
-
-
-
additional information
?
-
-
ATP, GTP and UTP, along with CDP and CMP cannot be used as substrates. The enzyme has a nearly undetectable activity toward 2-keto-3-deoxynononic acid and 2-keto-3-deoxyoctonic acid while no activity is detected with 3-deoxy-D-manno-2-octulosonic acid
-
-
-
additional information
?
-
-
does not utilize N-glycolylneuraminic acid as a substrate
-
-
?
additional information
?
-
-
does not utilize N-glycolylneuraminic acid as a substrate
-
-
?
additional information
?
-
the enzyme interacts with fragile X related protein 1
-
-
-
additional information
?
-
-
the enzyme is used for preparative synthesis of CMP-sialic acid derivatives in a one-pot two-enzyme system with EC 4.1.3.3 and EC 2.7.7.43
-
-
?
additional information
?
-
-
does not accept N-glycolylneuraminic acid and triacetylneuraminic acid as substrates
-
-
?
additional information
?
-
no substrate: 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid, kcat/Km value is about 5000fold lower than that of N-acetylneuraminate
-
-
?
additional information
?
-
-
no substrate: 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid, kcat/Km value is about 5000fold lower than that of N-acetylneuraminate
-
-
?
additional information
?
-
-
no activity with N-acetyl-9-O-acetylneuraminate
-
-
?
additional information
?
-
-
no substrates: 6'-thioneuraminate, 6-ketodeoxyoctulosonate
-
-
?
additional information
?
-
-
no substrates: 6'-thioneuraminate, 6-ketodeoxyoctulosonate
-
-
?
additional information
?
-
SaV CSS is a bifunctional enzyme having both CMP-sialic acid synthetase and acetylhydrolase (acylesterase) activities
-
-
?
additional information
?
-
-
SaV CSS is a bifunctional enzyme having both CMP-sialic acid synthetase and acetylhydrolase (acylesterase) activities
-
-
?
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CTP + N-acetylneuraminate
diphosphate + CMP-N-acetylneuraminate
-
-
-
?
CTP + N-acetylneuraminic acid
diphosphate + CMP-N-acetylneuraminic acid
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
CTP + N-glycolneuraminate
diphosphate + CMP-N-glycolneuraminate
-
N-glycolneuraminate is a relatively weaker substrate than N-acylneuraminate
-
-
?
CTP + sialic acid
CMP-sialic acid + diphosphate
CTP + sialic acid
diphosphate + CMP-sialic acid
-
-
-
?
CTP + N-acylneuraminate

diphosphate + CMP-N-acylneuraminate
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
the product of the reaction CMP-N-acylneuraminate is the substrate for the sialylation of glycoconjugates by sialyltransferases
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
the lec32 mutation reduces CMP-NeuAc synthetase activity to undetectable levels and reduces Neu-Ac on glycoproteins and glycolipids by 95%
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
CMP-NeuAc is essential for the formation of capsule polysialylate for strain K1
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
CMP-NeuAc is essential for the formation of capsule polysialylate for strain K1
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
neuroinvasive and septicaemia-causing pathogens often display a polysialic acid capsule that is involved in invasive behaviour. N-Acetylneuraminate is the basic monomer of polysialic acid. The activated form CMP-N-acylneuraminate is synthesized by N-acylneuraminate cytidylyltransferase
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
neuroinvasive and septicaemia-causing pathogens often display a polysialic acid capsule that is involved in invasive behaviour. N-Acetylneuraminate is the basic monomer of polysialic acid. The activated form CMP-N-acylneuraminate is synthesized by N-acylneuraminate cytidylyltransferase
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
production of CMP-N-acetylneuraminate is required for the synthesis of sialylated glycoconjugates
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
the enzyme is involved in the production of activated sialic acids
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
changes in the level of sialylation during development are intimately related to variations in the expression of the enzyme, at least in brain, heart, kidney, stomach, intestine and lung
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
the enzyme is involved in synthesis of capsular polysaccharide, the recombinant enzyme can function in K1 capsular polysaccharide biosynthesis in Escherichia coli
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
the enzyme is essential in capsular polysaccharide biosynthesis, activates N-acetylneuraminate for transfer to the nascent capsular polysaccharide
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
the enzyme is essential in capsular polysaccharide biosynthesis, activates N-acetylneuraminate for transfer to the nascent capsular polysaccharide
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
the enzyme produces CMP-N-acetylneuraminate, the nucleotide sugar donor used by sialyltransferase
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
-
the enzyme produces CMP-N-acetylneuraminate, the nucleotide sugar donor used by sialyltransferase
-
-
?
CTP + sialic acid

CMP-sialic acid + diphosphate
-
-
-
?
CTP + sialic acid
CMP-sialic acid + diphosphate
-
-
-
-
?
CTP + sialic acid
CMP-sialic acid + diphosphate
-
-
-
-
?
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0.56 - 3
2-keto-3-deoxy-D-glycero-D-galacto-nononic acid
0.56 - 3
3-deoxy-D-glycero-D-galacto-nononate
2.5
4-O-methyl-N-acetylneuraminate
-
pH 7, 37ưC
1.5 - 5.3
8-O-methyl-N-acetylneuraminate
2.1
CDP
-
pH 9.0, 37ưC, reaction with N-acetylneuraminate
0.62
deaminoneuraminic acid
-
1.2 - 1.4
N-acetyl-4-O-acetylneuraminate
1.1 - 1.6
N-acetyl-7(8)-O-acetylneuraminate
0.00036 - 7.6
N-acetylneuraminate
1.3
N-acetylneuraminate methyl ester
-
pH 9.0, 37ưC, reaction with CTP
0.26 - 2.8
N-acetylneuraminic acid
0.127 - 4
N-acylneuraminate
1.483 - 3.5
N-glycolneuraminate
-
1.2 - 6.2
N-glycolylneuraminate
0.16 - 0.35
N-glycolylneuraminic acid
2 - 7
N-methylglycolylneuraminate
8.1
TTP
-
pH 9.0, 37ưC, reaction with N-acetylneuraminate
3
UDP
-
pH 9.0, 37ưC, reaction with N-acetylneuraminate
2.7
UTP
-
pH 9.0, 37ưC, reaction with N-acetylneuraminate
0.56
2-keto-3-deoxy-D-glycero-D-galacto-nononic acid

pH 9.0, 37ưC
3
2-keto-3-deoxy-D-glycero-D-galacto-nononic acid
pH 9.0, 37ưC
0.56
3-deoxy-D-glycero-D-galacto-nononate

pH 9.0, 25ưC
3
3-deoxy-D-glycero-D-galacto-nononate
pH 9.0, 25ưC
1.5
8-O-methyl-N-acetylneuraminate

-
mutant S81R, pH 8.5, 37ưC
5.3
8-O-methyl-N-acetylneuraminate
-
wild-type, pH 8.5, 37ưC
0.00046
CTP

-
pH 9.0, 37ưC
0.0106
CTP
-
pH 7.1, 25ưC
0.017
CTP
wild-type, pH 7.5, 22ưC
0.026
CTP
mutant D211A, pH 7.5, 22ưC
0.031
CTP
mutant Q104A, pH 7.5, 22ưC
0.034
CTP
CMP-sialic acid synthetase
0.035
CTP
-
pH 7.1, 37ưC
0.035
CTP
-
at pH 7.1 and 37ưC
0.04
CTP
mutant Y179A, pH 7.5, 22ưC
0.042
CTP
N-terminal domain of CMP-sialic acid synthetase
0.043
CTP
N-terminal domain and C-terminal domain of CMP-sialic acid synthetase
0.048
CTP
mutant R173A, pH 7.5, 22ưC
0.052
CTP
mutant F193A, pH 7.5, 22ưC
0.08
CTP
-
at pH 7.5 and 25ưC
0.15
CTP
mutant F192A, pH 7.5, 22ưC
0.16
CTP
-
wild-type, pH 8.5, 37ưC
0.22
CTP
-
mutant S81R, pH 8.5, 37ưC
0.24
CTP
-
wild-type, pH 8.5, 37ưC
0.24
CTP
-
at 50ưC, 10 mM MnCl2, 50 mM Tris buffer (pH 9.5)
0.27
CTP
mutant N175A, pH 7.5, 22ưC
0.31
CTP
-
pH 9.0, 37ưC
0.36
CTP
-
pH 9.0, 37ưC, reaction with N-glycolylneuraminate
0.45
CTP
at pH 8.0 and 37ĆĀưC
0.59
CTP
-
wild-type, pH 8.5, 37ưC
0.6
CTP
-
pH 9.0, 37ưC
0.6
CTP
-
pH 9.0, 37ưC
1.3
CTP
-
pH 9.0, 37ưC
1.5
CTP
-
pH 8.0, 37ưC
1.57
CTP
-
pH 9.0, 30ưC
1.7
CTP
-
pH 9.3, 30ưC
1.77
CTP
-
pH 9.0, 37ưC, reaction with N-acetylneuraminate
2.6
CTP
-
pH 9.0, 37ưC, reaction with N-acetylneuraminate methyl ester
1.2
N-acetyl-4-O-acetylneuraminate

-
37ưC, crude enzyme extract
1.3
N-acetyl-4-O-acetylneuraminate
-
37ưC, crude enzyme extract
1.4
N-acetyl-4-O-acetylneuraminate
-
37ưC, crude enzyme extract
1.1
N-acetyl-7(8)-O-acetylneuraminate

-
37ưC, crude enzyme extract
1.1
N-acetyl-7(8)-O-acetylneuraminate
-
37ưC, crude enzyme extract
1.6
N-acetyl-7(8)-O-acetylneuraminate
-
37ưC, crude enzyme extract
0.00036
N-acetylneuraminate

-
pH 9.0, 37ưC
0.066
N-acetylneuraminate
mutant D211A, pH 7.5, 22ưC
0.068
N-acetylneuraminate
wild-type, pH 7.5, 22ưC
0.076
N-acetylneuraminate
-
pH 7.1, 25ưC
0.1
N-acetylneuraminate
-
mutant S81R, pH 8.5, 37ưC
0.11
N-acetylneuraminate
mutant Y179A, pH 7.5, 22ưC
0.14
N-acetylneuraminate
-
wild-type, pH 8.5, 37ưC
0.18
N-acetylneuraminate
-
wild-type, pH 8.5, 37ưC
0.22
N-acetylneuraminate
-
wild-type, pH 8.5, 37ưC
0.26
N-acetylneuraminate
-
pH 7.1, 37ưC
0.26
N-acetylneuraminate
pH 9.0, 37ưC
0.29
N-acetylneuraminate
mutant R173A, pH 7.5, 22ưC
0.34
N-acetylneuraminate
pH 8.5, 37ưC
0.34
N-acetylneuraminate
-
pH 9.0, 37ưC
0.38
N-acetylneuraminate
mutant F192A, pH 7.5, 22ưC
0.7
N-acetylneuraminate
-
pH 9, 37ưC
0.78
N-acetylneuraminate
mutant F193A, pH 7.5, 22ưC
0.867
N-acetylneuraminate
-
pH 9.0, 30ưC
1
N-acetylneuraminate
-
pH 9, 37ưC
1.2
N-acetylneuraminate
-
-
1.2
N-acetylneuraminate
-
37ưC, crude enzyme extract
1.3
N-acetylneuraminate
-
pH 8.0, 37ưC
1.4
N-acetylneuraminate
-
-
1.4
N-acetylneuraminate
-
37ưC, crude enzyme extract
1.6
N-acetylneuraminate
-
pH 9.0, 37ưC
1.6
N-acetylneuraminate
-
pH 9.0, 37ưC, reaction with TTP
1.6
N-acetylneuraminate
mutant N175A, pH 7.5, 22ưC
1.8
N-acetylneuraminate
-
pH 9.0, 37ưC, reaction with CDP
1.82
N-acetylneuraminate
-
pH 9.0, 37ưC, reaction with CTP
1.9
N-acetylneuraminate
-
pH 9.0, 37ưC, reaction with UTP
1.9
N-acetylneuraminate
-
pH 9.0, 37ưC, reaction with UDP
2.1
N-acetylneuraminate
-
pH 9.3, 30ưC
2.2
N-acetylneuraminate
-
-
2.6
N-acetylneuraminate
mutant Q104A, pH 7.5, 22ưC
2.8
N-acetylneuraminate
pH 9.0, 37ưC
4
N-acetylneuraminate
-
pH 9.0, 37ưC
7.6
N-acetylneuraminate
-
-
0.26
N-acetylneuraminic acid

pH 9.0, 25ưC
0.41
N-acetylneuraminic acid
at pH 8.0 and 37ĆĀưC
2.8
N-acetylneuraminic acid
pH 9.0, 25ưC
0.127
N-acylneuraminate

-
at pH 7.5 and 25ưC
0.13
N-acylneuraminate
-
-
0.13
N-acylneuraminate
-
at 50ưC, 10 mM MnCl2, 50 mM Tris buffer (pH 9.5)
0.26
N-acylneuraminate
-
at pH 7.1 and 37ưC
0.34
N-acylneuraminate
-
-
0.8
N-acylneuraminate
-
pH 9.0, 37ưC
1.82
N-acylneuraminate
-
-
4
N-acylneuraminate
-
at 37ưC
1.483
N-glycolneuraminate

-
at pH 7.5 and 25ưC
-
3.5
N-glycolneuraminate
at pH 8.0 and 37ĆĀưC
-
1.2
N-glycolylneuraminate

-
37ưC, crude enzyme extract
1.3
N-glycolylneuraminate
-
37ưC, crude enzyme extract
1.5
N-glycolylneuraminate
-
37ưC, crude enzyme extract
2.3
N-glycolylneuraminate
-
pH 9.0, 37ưC
2.3
N-glycolylneuraminate
-
pH 9.0, 37ưC
2.6
N-glycolylneuraminate
pH 8.5, 37ưC
2.9
N-glycolylneuraminate
-
pH 9.3, 30ưC
3
N-glycolylneuraminate
-
pH 9.0, 37ưC, reaction with CTP
4
N-glycolylneuraminate
-
mutant S81R, pH 8.5, 37ưC
6.2
N-glycolylneuraminate
-
wild-type, pH 8.5, 37ưC
0.16
N-glycolylneuraminic acid

-
at 50ưC, 10 mM MnCl2, 50 mM Tris buffer (pH 9.5)
0.35
N-glycolylneuraminic acid
-
2
N-methylglycolylneuraminate

-
wild-type, pH 8.5, 37ưC
7
N-methylglycolylneuraminate
-
mutant S81R, pH 8.5, 37ưC
0.045
sialic acid

CMP-sialic acid synthetase, substrate N-acetylneuraminic acid
0.063
sialic acid
N-terminal domain and C-terminal domain of CMP-sialic acid synthetase, substrate N-acetylneuraminic acid
0.07
sialic acid
N-terminal domain of CMP-sialic acid synthetase, substrate N-acetylneuraminic acid
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