BRENDA - Enzyme Database
show all sequences of 2.7.7.41

Biosynthesis of cytidine diphosphate-diglyceride by a particulate fraction from Micrococcus cerificans

McCaman, R.E.; Finnerty, W.R.; J. Biol. Chem. 243, 5074-5080 (1968)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
Cutsum
enhances activity
Micrococcus cerificans
non-ionic detergent
absolute requirement
Micrococcus cerificans
Triton X-100
stimulates
Micrococcus cerificans
Inhibitors
Inhibitors
Commentary
Organism
Structure
hydrazine
-
Micrococcus cerificans
sodium deoxycholate
-
Micrococcus cerificans
sodium lauryl sulfate
-
Micrococcus cerificans
Sulfram
-
Micrococcus cerificans
Tween 20
-
Micrococcus cerificans
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
K+
absolute requirement for
Micrococcus cerificans
Mg2+
stimulates, 3times more active than Mn2+, optimal activity at 10 mM
Micrococcus cerificans
Mn2+
stimulates
Micrococcus cerificans
NH4+
only about half of the activity observed with K+
Micrococcus cerificans
Rb+
only about half of the activity observed with K+
Micrococcus cerificans
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
CTP + phosphatidate
Micrococcus cerificans
enzyme is involved in synthesis of CDP-diglyceride, which plays a primary role in bacterial biosyntheses of essential phosphoglycerides
diphosphate + CDPdiacylglycerol
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Micrococcus cerificans
-
-
-
Purification (Commentary)
Commentary
Organism
partial
Micrococcus cerificans
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.1333
-
-
Micrococcus cerificans
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
CTP + phosphatidate
highly specific for CTP
643297
Micrococcus cerificans
diphosphate + CDPdiacylglycerol
-
-
-
?
CTP + phosphatidate
enzyme is involved in synthesis of CDP-diglyceride, which plays a primary role in bacterial biosyntheses of essential phosphoglycerides
643297
Micrococcus cerificans
diphosphate + CDPdiacylglycerol
-
-
-
?
dCTP + phosphatidate
50% of the activity with CTP
643297
Micrococcus cerificans
diphosphate + dCDPdiacylglycerol
-
-
-
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
45
-
-
Micrococcus cerificans
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
55
-
30 min, irreversible inactivation
Micrococcus cerificans
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
-
Micrococcus cerificans
pH Range
pH Minimum
pH Maximum
Commentary
Organism
6
9.3
pH 6.0: about 45% of maximal activity, pH 9.3: about 40% of maximal activity
Micrococcus cerificans
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
Cutsum
enhances activity
Micrococcus cerificans
non-ionic detergent
absolute requirement
Micrococcus cerificans
Triton X-100
stimulates
Micrococcus cerificans
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
hydrazine
-
Micrococcus cerificans
sodium deoxycholate
-
Micrococcus cerificans
sodium lauryl sulfate
-
Micrococcus cerificans
Sulfram
-
Micrococcus cerificans
Tween 20
-
Micrococcus cerificans
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
K+
absolute requirement for
Micrococcus cerificans
Mg2+
stimulates, 3times more active than Mn2+, optimal activity at 10 mM
Micrococcus cerificans
Mn2+
stimulates
Micrococcus cerificans
NH4+
only about half of the activity observed with K+
Micrococcus cerificans
Rb+
only about half of the activity observed with K+
Micrococcus cerificans
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
CTP + phosphatidate
Micrococcus cerificans
enzyme is involved in synthesis of CDP-diglyceride, which plays a primary role in bacterial biosyntheses of essential phosphoglycerides
diphosphate + CDPdiacylglycerol
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
partial
Micrococcus cerificans
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.1333
-
-
Micrococcus cerificans
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
CTP + phosphatidate
highly specific for CTP
643297
Micrococcus cerificans
diphosphate + CDPdiacylglycerol
-
-
-
?
CTP + phosphatidate
enzyme is involved in synthesis of CDP-diglyceride, which plays a primary role in bacterial biosyntheses of essential phosphoglycerides
643297
Micrococcus cerificans
diphosphate + CDPdiacylglycerol
-
-
-
?
dCTP + phosphatidate
50% of the activity with CTP
643297
Micrococcus cerificans
diphosphate + dCDPdiacylglycerol
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
45
-
-
Micrococcus cerificans
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
55
-
30 min, irreversible inactivation
Micrococcus cerificans
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
-
Micrococcus cerificans
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
6
9.3
pH 6.0: about 45% of maximal activity, pH 9.3: about 40% of maximal activity
Micrococcus cerificans
Other publictions for EC 2.7.7.41
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738826
Qi
CDP-diacylglycerol synthases r ...
Homo sapiens, Mus musculus
J. Lipid Res.
57
767-780
2016
-
-
-
-
2
-
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4
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4
-
4
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3
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4
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4
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4
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4
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6
-
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4
-
-
-
-
-
-
-
-
-
-
4
8
-
-
-
737701
DSouza
Distinct properties of the two ...
Homo sapiens
Biochemistry
53
7358-7367
2014
1
-
1
-
-
-
6
3
1
1
-
6
-
3
-
-
-
-
-
-
2
-
30
-
1
-
-
4
1
-
-
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-
-
-
2
-
2
-
-
-
-
-
10
-
6
2
2
-
6
-
-
-
-
-
-
2
-
30
-
2
-
-
4
2
-
-
-
-
2
4
-
-
-
739033
He
Increase in cellular triacylgl ...
Schizosaccharomyces japonicus, Schizosaccharomyces japonicus yFS275, Schizosaccharomyces pombe, Schizosaccharomyces pombe 972
Mol. Biol. Cell
25
4083-4095
2014
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-
-
-
1
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2
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-
4
-
6
-
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4
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2
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1
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-
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2
-
-
4
-
-
-
-
-
-
-
-
4
-
2
-
-
-
-
-
-
-
-
6
7
-
-
-
739396
Liu
CDP-diacylglycerol synthetase ...
Drosophila melanogaster
PLoS Genet.
10
e1004172
2014
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
10
-
-
1
-
-
-
-
-
-
-
-
-
-
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-
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-
-
-
-
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-
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-
1
-
-
-
-
-
10
-
-
1
-
-
-
-
-
-
-
-
-
-
2
3
-
-
-
741020
Lilley
The essential roles of cytidin ...
Trypanosoma brucei 927, Trypanosoma brucei brucei
Mol. Microbiol.
92
453-470
2014
-
-
1
-
1
-
-
-
3
-
1
2
-
7
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
3
-
1
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
4
4
-
-
-
723221
Serricchio
Phosphatidylglycerophosphate s ...
Trypanosoma brucei brucei, Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927
Mol. Microbiol.
87
569-579
2013
-
-
-
-
-
-
-
-
-
-
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-
-
2
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-
-
-
-
-
-
-
-
1
1
-
-
-
738000
Tamura
Tam41 is a CDP-diacylglycerol ...
Saccharomyces cerevisiae
Cell Metab.
17
709-718
2013
-
-
-
-
2
-
1
4
4
3
-
1
-
3
-
-
-
-
-
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-
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3
-
-
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-
-
-
1
-
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-
-
-
-
-
-
2
-
-
1
-
4
4
3
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
1
-
-
-
4
4
-
-
-
739305
Zhou
Extraplastidial cytidinediphos ...
Arabidopsis thaliana
Plant J.
75
867-879
2013
1
-
1
-
1
-
-
-
4
1
-
3
-
6
-
-
-
-
-
2
-
-
14
-
-
-
-
-
2
-
-
-
-
-
-
3
-
2
-
-
2
-
-
-
-
-
9
3
-
3
-
-
-
-
-
5
-
-
14
-
-
-
-
-
3
-
-
-
-
3
8
-
-
-
722903
Waugh
CDP-diacylglycerol phospholipi ...
Homo sapiens
J. Lipid Res.
52
2148-2158
2011
-
-
-
-
-
-
-
-
1
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1
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1
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1
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1
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-
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-
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-
-
-
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-
-
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-
722419
Shastri
Plasmodium CDP-DAG synthase: a ...
Plasmodium falciparum
Int. J. Parasitol.
40
1257-1268
2010
-
-
-
-
-
-
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2
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4
-
1
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2
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1
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-
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-
1
1
1
1
-
-
691056
Laczko-Dobos
Role of phosphatidylglycerol i ...
Synechocystis sp.
Biochim. Biophys. Acta
1777
1184-1194
2008
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-
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-
1
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4
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1
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1
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1
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-
690426
Mercade
Characterization and physical ...
Sus scrofa
Anim. Biotechnol.
18
23-35
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
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-
1
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1
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1
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1
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-
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-
-
-
-
659064
Nishibori
Phosphatidylethanolamine domai ...
Bacillus subtilis, Bacillus subtilis Marburg / DSM 10 / ATCC 6051
J. Bacteriol.
187
2163-2174
2005
-
-
1
-
-
-
-
-
1
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2
-
7
-
-
-
-
-
-
-
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4
-
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1
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1
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2
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4
-
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-
-
-
-
-
-
-
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-
-
661820
Inglis-Broadgate
Isolation and characterization ...
Mus musculus
Gene
356
19-31
2005
-
-
1
-
-
-
-
-
1
-
2
2
-
5
-
1
-
-
-
9
-
-
4
1
-
-
-
-
-
-
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-
-
2
-
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2
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2
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2
2
-
-
2
-
-
10
-
-
4
2
-
-
-
-
-
-
-
2
-
-
-
-
-
-
662589
Jiang
Stimulation of cardiac cardiol ...
Mus musculus, Rattus norvegicus
J. Lipid Res.
45
244-252
2004
-
-
-
-
-
-
-
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2
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2
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2
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4
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2
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2
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4
-
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-
-
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-
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-
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-
643320
Martin
Characterization of Plasmodium ...
Plasmodium falciparum
Mol. Biochem. Parasitol.
110
93-105
2000
-
-
1
-
-
-
-
-
-
-
-
1
-
3
-
1
-
-
-
3
-
-
2
1
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-
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1
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1
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-
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-
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1
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1
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3
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
643317
Weber
A prototypical cytidylyltransf ...
Bacillus subtilis
Structure Fold. Des.
7
1113-1124
1999
-
-
-
1
-
-
-
-
-
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1
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-
-
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1
1
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1
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-
-
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-
-
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1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
643318
Weeks
Isolation and expression of an ...
Homo sapiens
DNA Cell Biol.
16
281-289
1997
-
-
1
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
643319
Heacock
CDP-diacylglycerol synthase fr ...
Cavia porcellus, Drosophila sp. (in: Insecta), Escherichia coli, Homo sapiens, Rattus norvegicus, Sus scrofa
Biochim. Biophys. Acta
1348
166-172
1997
-
-
1
-
-
-
-
2
2
3
-
12
-
6
-
-
-
-
-
6
-
-
23
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
2
3
-
12
-
-
-
-
-
6
-
-
23
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
643321
Dowhan
CDP-diacylglycerol synthase of ...
Escherichia coli, Saccharomyces cerevisiae
Biochim. Biophys. Acta
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1997
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Monaco
Extraction and stabilization o ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
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1997
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643323
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The role of CDP-diacylglycerol ...
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1997
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Kopka
Complementary DNAs encoding eu ...
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1997
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643325
Saito
Gene cloning and characterizat ...
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1997
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643328
Shen
Regulation of phospholipid bio ...
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643327
Shen
The CDS1 gene encoding CDP-dia ...
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643316
Wu
Regulation of PLC-mediated sig ...
Drosophila sp. (in: Insecta)
Nature
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1995
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643307
Hanenberg
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Characterization of cytidine t ...
Catharanthus roseus
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1993
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643300
Sparrow
Purification of CDPdiacylglyce ...
Escherichia coli
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643301
Carman
CDPdiacylglycerol synthase fro ...
Saccharomyces cerevisiae
Methods Enzymol.
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242-247
1992
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643302
Mok
CDP-diacylglycerol synthesis i ...
Rattus norvegicus
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236-240
1992
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643298
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Bovine brain microsomal CDP-di ...
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Kelley
Purification and characterizat ...
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Purification and properties of ...
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643306
Gaillard
Specific inhibition of phospha ...
Bacillus subtilis
Biochim. Biophys. Acta
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Carman
CDP-diacylglycerol synthase ac ...
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81-85
1982
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643311
Sribney
Biosynthesis of CDP-diacylglyc ...
Sus scrofa
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668-674
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643304
Liteplo
The stimulation of rat liver m ...
Rattus norvegicus
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643310
Belendiuk
CTP-phosphatidic acid cytidylt ...
Saccharomyces cerevisiae
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4555-4565
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Langley
Partial purification and prope ...
Escherichia coli
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Van Heusden
The influence of exogenous and ...
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643305
Sribney
Studies on the synthesis of CD ...
Rattus norvegicus
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643313
Sturton
Factors controlling the activi ...
Rattus norvegicus
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Bishop
Studies on the formation by ra ...
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McCaman
Biosynthesis of cytidine dipho ...
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643299
Petzold
The biosynthesis of cytidine d ...
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