Literature summary for 2.7.7.15 extracted from

Yue, L.; McPhee, M.J.; Gonzalez, K.; Charman, M.; Lee, J.; Thompson, J.; Winkler, D.F.H.; Cornell, R.B.; Pelech, S.; Ridgway, N.D.
Differential dephosphorylation of CTP phosphocholine cytidylyltransferase upon translocation to nuclear membranes and lipid droplets (2020), Mol. Biol. Cell, 31, 1047-1059 .

Search for more literature for 2.7.7.15

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nuclear membrane	nuclear membrane association of CCTa induced by oleate loading is linked to dephosphorylation of S319	Homo sapiens	31965	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
CTP + phosphocholine	Homo sapiens	-	diphosphate + CDP-choline	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P49585	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	oleate treatment of cultured cells triggers CCTalpha translocation to the nuclear envelope and nuclear lipid droplets and rapid dephosphorylation of pS319. Removal of oleate leads to dissociation of CCTalpha from the nuclear envelope and increased phosphorylation of S319. Choline depletion of cells causes CCTalpha translocation to the nuclear envelope and S319 dephosphorylation. Y359 and S362 are constitutively phosphorylated during oleate addition and removal. The P-domain undergoes negative charge polarization due to dephosphorylation of S319 and possibly other proline-directed sites and retention of Y359 and S362 phosphorylation. Dephosphorylation of S319 and S315 is involved in CCTalpha recruitment to nuclear membranes	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CTP + phosphocholine	-	Homo sapiens	diphosphate + CDP-choline	-	?

Synonyms

Synonyms	Comment	Organism
CCTalpha	-	Homo sapiens
CTP:phosphocholine cytidylyltransferase	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha) and CCTbeta catalyze the rate limiting step in phosphatidylcholine biosynthesis	Homo sapiens

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Release 2023.1 (January 2023)