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Information on EC 2.7.7.15 - choline-phosphate cytidylyltransferase
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2.7.7.15 choline-phosphate cytidylyltransferaseSpecify your search results
Word Map
- 2.7.7.15
- phosphatidylcholine
- phospholipid
- phosphatidylethanolamine
- surfactant
- fetal
- diacylglycerol
- phospholipase
-
ptdcho
- alveolar
-
cholinephosphotransferase
- oleate
- phosphatidylglycerol
-
amphipathic
-
membrane-binding
- n-methyltransferase
-
disaturated
- lysophosphatidylcholine
- phosphatidate
-
3hcholine
-
vance
-
kennedy
-
cytidyltransferase
- 1,2-diacylglycerols
- phosphoethanolamine
-
3hglycerol
-
amphitropic
-
l-forms
-
methyl-14ccholine
- hexadecylphosphocholine
- analysis
- diagnostics
-
choline-deficient
- cdpcholine
-
methyl-3hcholine
-
2.7.8.2
-
14ccholine
-
ctp:phosphoethanolamine
-
choline-containing
- cdp-ethanolamine
- medicine
The enzyme appears in viruses and cellular organisms
Synonyms
ctp:phosphocholine cytidylyltransferase, cctalpha, ctalpha, phosphocholine cytidylyltransferase, pcyt1a, cholinephosphate cytidylyltransferase, cctbeta, choline-phosphate cytidylyltransferase, ctp:phosphocholine cytidylyltransferase alpha, ctp:choline-phosphate cytidylyltransferase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
CCT
CCT-alpha
CCT1
CCT2
CCTalpha
CCTbeta2
CCTbeta3
CDP-choline pyrophosphorylase
-
-
-
-
CDP-choline synthetase
-
-
-
-
choline phosphate cytidylyltransferase
CTP-phosphocholine cytidylyltransferase
-
-
-
-
CTP:cholinephosphate cytidylyltransferase
-
-
-
-
CTP:phosphocholine cytidylyltransferase
CTP:phosphocholine cytidylyltransferase alpha
CTP:phosphocholine cytidylyltransferase beta2
CTP:phosphocholine cytidylyltransferase-alpha
CTP:phosphocholine cytidylyltransferase-beta2
CTP:phosphorylcholine cytidylyltransferase
-
-
-
-
cytidine diphosphocholine pyrophosphorylase
-
-
-
-
cytidylyltransferase, choline phosphate
-
-
-
-
phosphocholine cytidylyltransferase
-
-
-
-
phosphorylcholine cytidylyltransferase
-
-
-
-
phosphorylcholine transferase
-
-
-
-
phosphorylcholine:CTP cytidylyltransferase
-
-
-
-
additional information
CCT
-
-
-
-
choline phosphate cytidylyltransferase
-
-
-
-
CTP:phosphocholine cytidylyltransferase
-
-
-
-
additional information
-
different isoforms, CCTalpha and CCTbeta 2 and -3, CCTbeta 1 is not found in mice
additional information
-
four isoforms, CCTalpha ubiquitously expressed, whereas CCTbeta 1,-2, and -3 restricted in distribution
additional information
-
four isoforms, CCTalpha ubiquitously expressed, whereas CCTbeta 1,-2, and -3 restricted in distribution
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
CTP + phosphocholine = diphosphate + CDP-choline
catalytic mechanism
-
CTP + phosphocholine = diphosphate + CDP-choline
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
nucleotidyl group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
CTP:choline-phosphate cytidylyltransferase
-
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CAS REGISTRY NUMBER
COMMENTARY
9026-34-0
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CTP + phosphodimethylethanolamine
diphosphate + CDPdimethylethanolamine
-
-
-
-
?
CTP + choline phosphate
diphosphate + CDP-choline
-
rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, involved in cold acclimation
-
-
?
CTP + choline phosphate
diphosphate + CDP-choline
-
-
-
?
CTP + choline phosphate
diphosphate + CDP-choline
-
rate limiting enzyme for the synthesis of phosphatidylcholine
-
-
?
CTP + choline phosphate
diphosphate + CDP-choline
-
rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis
-
-
?
CTP + choline phosphate
diphosphate + CDP-choline
-
rate limiting enzyme for the synthesis of phosphatidylcholine
-
-
?
CTP + choline phosphate
diphosphate + CDP-choline
-
-
-
-
?
CTP + choline phosphate
diphosphate + CDP-choline
-
rate limiting enzyme for the synthesis of phosphatidylcholine
-
-
?
CTP + choline phosphate
diphosphate + CDP-choline
-
rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, disruption of CCTbeta leads to gonadal dysfunction and reduced fertility
-
-
?
CTP + choline phosphate
diphosphate + CDP-choline
-
-
-
-
?
CTP + choline phosphate
diphosphate + CDP-choline
-
rate limiting enzyme for the synthesis of phosphatidylcholine
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
-
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
rate limiting step in synthesis of phosphatidylcholine
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
dCTP can replace CTP with reduced activity
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
-
642894, 642895, 642896, 642898, 642900, 642902, 642903, 642904, 642905, 642906, 642907, 642908, 642909, 642913, 642914, 642915, 642916, 642919, 642921, 642923, 642924, 642926, 642928
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
highly specific for phosphocholine
-
-
r
CTP + choline phosphate
diphosphate + CDPcholine
-
beta2 isoform specifically up-regulated during neuronal differentiation to increase phosphatidyl choline biosynthesis for growing neuritis
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
rate limiting step in synthesis of phosphatidylcholine
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
membrane binding segment has important role in cellular lipid metabolism
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
catalyzes a major rate-limiting step in the biosynthesis of phosphocholine
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
catalyzes a major rate-limiting step in the biosynthesis of phosphocholine
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
highly specific for CTP or dCTP
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
ATP can replace CTP with less efficiency
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
plays a role in the biosynthesis of the phosphocholine-derivatized cell wall constituents that are critical for cell separation and pathogenesis
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
biosynthesis of the choline containing cell wall antigens, teichoic acid and lipoteichoic acid
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
biosynthesis of the choline containing cell wall antigens, teichoic acid and lipoteichoic acid
-
-
?
CTP + ethanolamine phosphate
diphosphate + CDPethanolamine
-
poor substrate
-
-
?
CTP + phosphocholine
diphosphate + CDP-choline
when dissociated from membranes, a portion of the M domain functions as an auto-inhibitory element to suppress catalysis. It is proposed that membrane binding enables bending of thex02E helices, bringing the active site closer to the membrane surface
-
-
?
CTP + phosphomonomethylethanolamine
diphosphate + CDPmethylethanolamine
-
-
-
-
?
CTP + phosphomonomethylethanolamine
diphosphate + CDPmethylethanolamine
-
-
-
?
additional information
?
-
-
key regulatory enzyme in the CDP-choline pathway for the biosynthesis of phosphatidylcholine, hepatic phosphatidylcholine biosynthesis is an important regulator of plasma high density lipoprotein
-
-
?
additional information
?
-
-
active lipoprotein form, i.e. H-form, is the membrane-associated form of the enzyme in adult lung
-
-
?
additional information
?
-
-
comparison of lipid regulation of yeast and rat enzyme
-
-
?
additional information
?
-
-
H-form is the active form of enzyme in cytoplasm
-
-
?
additional information
?
-
-
change in relative distribution of H-form and L-form in cytosol may be important in the regulation of phosphatidylcholine synthesis
-
-
?
additional information
?
-
-
active form of enzyme on the ER, enzyme in cytosol appears to be latent
-
-
?
additional information
?
-
-
CTbeta2 facilitates neurite outgrowth and branching
-
-
?
additional information
?
-
-
development of an assay method for determination of the catalytic activity measuring the production of radiolabeled CDP-choline from 14C-labeled phosphocholine, and separation of non-radioactive CDP-choline from CTP by C18 reverse phase HPLC using a mobile phase of 0.1 M ammonium bicarbonate (98%) and acetonitrile (2%) at pH 7.4, evaluation, overview
-
-
?
additional information
?
-
-
no substrates: ethanolamine phosphate and phosphodimethylethanolamine
-
-
?
additional information
?
-
-
comparison of lipid regulation of yeast and rat enzyme
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CTP + choline phosphate
diphosphate + CDP-choline
-
rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, involved in cold acclimation
-
-
?
CTP + choline phosphate
diphosphate + CDP-choline
-
rate limiting enzyme for the synthesis of phosphatidylcholine
-
-
?
CTP + choline phosphate
diphosphate + CDP-choline
-
rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis
-
-
?
CTP + choline phosphate
diphosphate + CDP-choline
-
rate limiting enzyme for the synthesis of phosphatidylcholine
-
-
?
CTP + choline phosphate
diphosphate + CDP-choline
-
rate limiting enzyme for the synthesis of phosphatidylcholine
-
-
?
CTP + choline phosphate
diphosphate + CDP-choline
-
rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, disruption of CCTbeta leads to gonadal dysfunction and reduced fertility
-
-
?
CTP + choline phosphate
diphosphate + CDP-choline
-
rate limiting enzyme for the synthesis of phosphatidylcholine
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
rate limiting step in synthesis of phosphatidylcholine
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
beta2 isoform specifically up-regulated during neuronal differentiation to increase phosphatidyl choline biosynthesis for growing neuritis
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
rate limiting step in synthesis of phosphatidylcholine
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
membrane binding segment has important role in cellular lipid metabolism
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
catalyzes a major rate-limiting step in the biosynthesis of phosphocholine
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
catalyzes a major rate-limiting step in the biosynthesis of phosphocholine
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
plays a role in the biosynthesis of the phosphocholine-derivatized cell wall constituents that are critical for cell separation and pathogenesis
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
biosynthesis of the choline containing cell wall antigens, teichoic acid and lipoteichoic acid
-
-
?
CTP + choline phosphate
diphosphate + CDPcholine
-
biosynthesis of the choline containing cell wall antigens, teichoic acid and lipoteichoic acid
-
-
?
additional information
?
-
-
key regulatory enzyme in the CDP-choline pathway for the biosynthesis of phosphatidylcholine, hepatic phosphatidylcholine biosynthesis is an important regulator of plasma high density lipoprotein
-
-
?
additional information
?
-
-
active lipoprotein form, i.e. H-form, is the membrane-associated form of the enzyme in adult lung
-
-
?
additional information
?
-
-
comparison of lipid regulation of yeast and rat enzyme
-
-
?
additional information
?
-
-
H-form is the active form of enzyme in cytoplasm
-
-
?
additional information
?
-
-
change in relative distribution of H-form and L-form in cytosol may be important in the regulation of phosphatidylcholine synthesis
-
-
?
additional information
?
-
-
active form of enzyme on the ER, enzyme in cytosol appears to be latent
-
-
?
additional information
?
-
-
CTbeta2 facilitates neurite outgrowth and branching
-
-
?
additional information
?
-
-
comparison of lipid regulation of yeast and rat enzyme
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Co2+
Co2+ results in significant activity at a concentration of 25 mM, with 41% of the activity seen with 25 mM Mg2+, the cation preference of CCT1 is Mg2+ > Mn2+/Co2+ > Ca2+/Ni2+ > Zn2+
Mg2+
Mn2+
Ni2+
Ni2+ yields approximately 9% of the activity seen with Mg2+, the cation preference of CCT1 is Mg2+ > Mn2+/Co2+ > Ca2+/Ni2+ > Zn2+
Zn2+
Zn2+ results in catalytic activity of only 1% when compared to the activity in the presence of Mg2+, the cation preference of CCT1 is Mg2+ > Mn2+/Co2+ > Ca2+/Ni2+ > Zn2+
Ca2+
Ca2+ yields approximately 9% of the activity seen with Mg2+, the cation preference of CCT1 is Mg2+ > Mn2+/Co2+ > Ca2+/Ni2+ > Zn2+
Mg2+
the cation preference of CCT1 is Mg2+ > Mn2+/Co2+ > Ca2+/Ni2+ > Zn2+
Mg2+
-
maximal activity at 10-40 mM, concentrations above 40 mM are inhibitory
Mn2+
Mn2+ results in significant activity at a concentration of 25 mM, with 51% of the activity seen with 25 mM Mg2+, the cation preference of CCT1 is Mg2+ > Mn2+/Co2+ > Ca2+/Ni2+ > Zn2+
Mn2+
-
can partially replace Mg2+, maximal activity at 5 mM, concentrations above 5 mM are inhibitory
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
calpain
-
calpain degrades CCTalpha, 0.6 pmol of calpain effectively cleaves 80% of purified CCTalpha (0.7 pmol) in the absence of calmodulin
-