Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-iodo-5'-fluoro-2',5'-dideoxyuridine | - |
Human alphaherpesvirus 1 | |
5-iodo-dUMP | competitive versus both thymidylate and thymidine | Human alphaherpesvirus 1 | |
ADP | ADP*Mg2+ product inhibition, competitive versus MgATP2-, noncompetitive versus thymidylate | Human alphaherpesvirus 1 | |
dTDP | product inhibition, competitive versus MgATP2- | Human alphaherpesvirus 1 | |
dTTP | competitive versus both thymidine and thymidylate | Human alphaherpesvirus 1 | |
MgADP- | - |
Human alphaherpesvirus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human alphaherpesvirus 1 | - |
thymidine/thymidylate multifunctional kinase | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + dTMP = ADP + dTDP | addition of substrates to the enzyme is random, while release of the products is ordered | Human alphaherpesvirus 1 |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | thymidine/thymidylate multifunctional kinase | Human alphaherpesvirus 1 | ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0006 | - |
5-iodo-5'-fluoro-2',5'-dideoxyuridine | versus thymidylate | Human alphaherpesvirus 1 | |
0.0009 | - |
5-iodo-5'-fluoro-2',5'-dideoxyuridine | versus thymidine | Human alphaherpesvirus 1 | |
0.05 | - |
dTTP | verus thymidylate | Human alphaherpesvirus 1 | |
0.059 | - |
dTDP | versus thymidylate | Human alphaherpesvirus 1 | |
0.06 | - |
MgADP- | versus ATP*Mg2+ | Human alphaherpesvirus 1 | |
0.062 | - |
dTTP | versus thymidine | Human alphaherpesvirus 1 | |
0.1 | - |
MgADP- | versus thymidylate | Human alphaherpesvirus 1 |