Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(NH4)2SO4 | 0.35 M, 50% inhibition | Saccharomyces cerevisiae | |
5-iodo-dUMP | 2.5 mM, 30% inhibition | Saccharomyces cerevisiae | |
ADP | 2.5 mM, 24% inhibition | Saccharomyces cerevisiae | |
dADP | 2.5 mM, 23% inhibition | Saccharomyces cerevisiae | |
dTDP | 2.5 mM, 75% inhibition | Saccharomyces cerevisiae | |
dTTP | 2.5 mM, 17% inhibition | Saccharomyces cerevisiae | |
dUDP | 2.5 mM, 15% inhibition | Saccharomyces cerevisiae | |
dUMP | 2.5 mM, 19% inhibition | Saccharomyces cerevisiae | |
KCl | 0.5 M, 10% inhibition | Saccharomyces cerevisiae | |
thymidine | 2.5 mM, 40% inhibition | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Saccharomyces cerevisiae | 5737 | - |
mitochondrion | no activity in mitochondria | Saccharomyces cerevisiae | 5739 | - |
nucleus | - |
Saccharomyces cerevisiae | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | divalent cation required, Co2 can fully substitute for Mg2+ | Saccharomyces cerevisiae | |
Fe2+ | divalent cation required, Fe2+ can fully substitute for Mg2+ | Saccharomyces cerevisiae | |
Mg2+ | divalent cation required | Saccharomyces cerevisiae | |
Mn2+ | divalent cation required, Mn2+ can fully substitute for Mg2+ | Saccharomyces cerevisiae | |
NaCl | from 0-0.5 M does not affect activity | Saccharomyces cerevisiae | |
Ni2+ | divalent cation required, Ni2+ can fully substitute for Mg2+ | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 5-iodo-dUMP | 34% of the activity with dTMP | Saccharomyces cerevisiae | ADP + 5-iodo-dUDP | - |
? | |
ATP + dTMP | - |
Saccharomyces cerevisiae | ADP + dTDP | - |
? | |
ATP + dUMP | 31% of the activity with dTMP | Saccharomyces cerevisiae | ADP + dUDP | - |
? | |
CTP + dTMP | 26% of the activity with ATP | Saccharomyces cerevisiae | CDP + dTDP | - |
? | |
dATP + dTMP | 92% of the activity with ATP | Saccharomyces cerevisiae | dADP + dTDP | - |
? | |
dCTP + dTMP | 49% of the activity ATP | Saccharomyces cerevisiae | dCDP + dTDP | - |
? | |
dGTP + dTMP | 42% of the activity with ATP | Saccharomyces cerevisiae | dGDP + dTDP | - |
? | |
GTP + dTMP | 35% of the activity with ATP | Saccharomyces cerevisiae | GDP + dTDP | - |
? | |
UTP + dTMP | 36% of the activity with ATP | Saccharomyces cerevisiae | UDP + dTDP | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
10 min, in absence of substrate activity decreases to 32% of the initial activity, completely stable in presence of 10 mM dTMP | Saccharomyces cerevisiae |
60 | - |
10 min, in absence of substrate activity decreases to 1% of the initial activity, partial protection in presence of 10 mM dTMP | Saccharomyces cerevisiae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | 9 | - |
Saccharomyces cerevisiae |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 9 | pH 5: about 45% of maximal activity, pH 6-9: optimum | Saccharomyces cerevisiae |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.62 | - |
dTDP | pH 8.0, 37°C | Saccharomyces cerevisiae |