Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.3.2 extracted from

  • Cheng, Y.; Li, R.; Lin, Z.; Chen, F.; Dai, J.; Zhu, Z.; Chen, L.; Zhao, Y.
    Structure-activity relationship analysis of dammarane-type natural products as muscle-type creatine kinase activators (2020), Bioorg. Med. Chem. Lett., 30, 127364 .
    View publication on PubMed
Search for more literature for 2.7.3.2

Activating Compound

Activating Compound Comment Organism Structure
20(R)-protopanaxadiol 23.5% increase of activity at 0.02 mM Homo sapiens
20(R)-protopanaxadiol significantly increases the enzyme activity Oryctolagus cuniculus
20(S)-protopanaxadiol best activator Oryctolagus cuniculus
20(S)-protopanaxadiol best activator of isoform CK-MM, 54.3% increase of activity at 0.04 mM Homo sapiens
20(S)-protopanaxatriol 32.2% increase of activity at 0.02 mM Homo sapiens
20(S)-protopanaxatriol significantly increases the enzyme activity Oryctolagus cuniculus
24-carboxy-protopanaxadiol 17.3% increase of activity at 0.005 mM Homo sapiens
24-COOH-protopanaxadiol significantly increases the enzyme activity Oryctolagus cuniculus
25-hydroxy-protopanaxadiol 23.5% increase of activity at 0.02 mM Homo sapiens
25-OH-protopanaxadiol significantly increases the enzyme activity Oryctolagus cuniculus
ginsenoside Rh2 3.5% increase of activity at 0.04 mM Homo sapiens
ginsenoside Rh2 significantly increases the enzyme activity Oryctolagus cuniculus
additional information not influenced by panaxatriol, ocotillol, ginsenoside Rg1, and ginsenoside Rd Homo sapiens
additional information panaxatriol, ocotillol, ginsenoside Rg1, and ginsenoside Rd have no significant influence on the enzyme activity Oryctolagus cuniculus
panaxadiol 15.4% increase of activity at 0.08 mM Homo sapiens
panaxadiol significantly increases the enzyme activity Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
jujubogenin 16.9% inhibition at 0.005 mM Homo sapiens
jujubogenin
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + creatine Homo sapiens
-
 ADP + phosphocreatine
-
 ?
ATP + creatine Oryctolagus cuniculus
-
 ADP + phosphocreatine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P06732
-
-
Oryctolagus cuniculus P00563
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
 Homo sapiens
-
skeletal muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + creatine
-
 Homo sapiens ADP + phosphocreatine
-
 ?
ATP + creatine
-
 Oryctolagus cuniculus ADP + phosphocreatine
-
 ?

Synonyms

Synonyms Comment Organism
CK-MM
-
 Homo sapiens
CK-MM
-
 Oryctolagus cuniculus
muscle creatine kinase
-
 Homo sapiens
muscle-type creatine kinase
-
 Homo sapiens
muscle-type creatine kinase
-
 Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Oryctolagus cuniculus