Application | Comment | Organism |
---|---|---|
medicine | NME1 expression is associated with reduced overall and event-free survival of neuroblastoma patients and with the strongest associations of any of the NME family member genes. NME1 expression is also higher in tumors with MYCN oncogene amplification and in tumors from patients with stage 4 disease. Isoforms NME1/NMe2 and multiple phosphorylated His-containing proteins are found in all tested neuroblastoma cell lines and in xenograft neuroblastoma tumors. NME1 expression is asssociated with neuroblastoma cell migration and differentiation | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P15531 | cf. EC 2.7.4.6 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation at residue H118 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
NM23 | - |
Homo sapiens |
NME1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | NME1 depletion impacts migration and differentiation but not proliferation in neuroblastoma cells. Candidate targets of NME1 histidine kinase activity include ENO1, GAPDH, and PKM | Homo sapiens |