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Information on EC 2.7.13.3 - histidine kinase
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2.7.13.3 histidine kinaseIUBMB Comments
This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine). A number of histones can act as acceptor.
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Word Map
- 2.7.13.3
- kinases
- autophosphorylation
- photoreceptors
-
far-red
- seedling
-
phosphorelay
- subtilis
-
biofilms
- chromophore
-
perception
-
regulons
- hypocotyls
-
perceived
-
quorum
- chey
-
light-induced
-
chemoreceptor
-
senses
-
flagellar
- pfr
- synechocystis
-
etiolated
-
autoinducer
- crescentus
-
photomorphogenesis
-
cryptochrome
-
quorum-sensing
- biliverdin
-
fluence
-
transmitter
-
histidine-containing
- caulobacter
- deinococcus
-
extracytoplasmic
-
diguanylate
- radiodurans
- phototropins
-
transphosphorylation
- arca
-
gravitropism
-
chemosensory
-
methyl-accepting
-
dark-grown
- myxococcus
- c-di-gmp
- ompc
-
photoresponses
- xanthus
- spo0a
-
four-helix
- medicine
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
33277 FimS, AaHSK1, adaptive-response sensory-kinase A, aerobic respiration control sensor protein arcB, aerobic respiration control sensor protein arcB homolog, aerobic respiration control sensor/response regulatory protein, AfGcHK, AgrC, AHK, AHK5, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
33277 FimS
AaHSK1
aerobic respiration control sensor protein arcB
AHK
AHK5
alkaline phosphatase synthesis sensor protein phoR
Arabidopsis histidine kinase
Arabidopsis histidine kinase 5
At2g47430
BA2291
BAB2_0652
BarA sensor kinase (sensory histidine kinase)
Q9L9E4
-
BinK
blue-light-activated histidine kinase
BOS1
BSU19190
BSU40400
C4-dicarboxylate transport sensor protein dctB
CheA
chemotaxis protein cheA
ChiS
Chk1p
CinS
CitA
CKI1
CKI1 histidine kinase
class I HK
class III HK
copper resistance, histidine kinase
-
CovS
CusS
cytokinin independent I histidine kinase
cytokinin independent1
DCC-1 protein
DctB
DcuS
DesK
development and carotenogenesis control-1 protein
DosT
Drak
DraK histidine kinase
ENVZ
ethylene receptor
ethylene resistant 1
-
the carboxyl-terminal part of ethylene resistant 1 consists of a histidine kinase domain and a response regulator domain
ETR1
EvgS
FimS
FimS histidine kinase
FrzE
Group III histidine kinase
Group III HK
group III two-component histidine kinase
-
heme-nitric oxide oxygen binding proteins-associated histidine kinase
-
-
high-affinity potassium transport system
Q8ZQW4
-
Hik2
Hik34
HISTIDIN kinase (histidine protein kinase PlnB, sensor protein)
histidine autokinase
histidine kinase
histidine kinase CKI1
histidine kinase PilS
histidine protein kinase
histidine sensor kinase
HK1
HK2
HP0244
hybrid histidine kinase
HydH
iron-sensing histidine kinase
KINA
KinC
KinD
LadS
LOV
LOVHK
NCU00939
NikA
nitrate/nitrite sensor protein narQ
nitrate/nitrite sensor protein narX
nitrogen regulation protein NR(II)
nitrogen regulation protein ntrB
nitrogen regulation protein ntrY
nodulation protein V
NreB
osmolarity sensor protein envZ
osmolarity two-component system protein SLN1
-
PdhS
PGN_0904
PhoQ
phosphate regulon sensor protein phoR
phosphoglycerate transport system sensor protein pgtB
-
phytochrome-like protein cph1 (light-regulated histidine)
-
PleC
PleC-DivJ homolog sensor
PleCHKD
the PleC kinase domain has histidine kinase activity
RaxH
SaeS
SAOUHSC_00021
SasA
SCO3062
secretion system regulator:sensor component
-
SenS
sensor histidine kinase
sensor histidine kinase A
sensor histidine kinase D
sensor histidine kinase mtrB
sensor kinase citA
sensor kinase cusS
sensor kinase dpiB
sensor protein atoS
sensor protein baeS
sensor protein barA
-
sensor protein basS/pmrB
sensor protein chvG
sensor protein chvG (histidine kinase sensory protein)
-
sensor protein citS
sensor protein cpxA
-
sensor protein creC
sensor protein dcuS
sensor protein degS
sensor protein evgS precursor
sensor protein fixL
sensor protein irlS
sensor protein kdpD
sensor protein phoQ
sensor protein qseC
sensor protein rcsC
sensor protein rcsC (capsular synthesis regulator)
sensor protein resE
sensor protein roxS
sensor protein rstB
sensor protein torS
sensor protein uhpB
sensor protein zraS
sensor with histidine kinase
sensor-like histidine kinase senX3
sensory histidine kinase
sensory histidine kinase in two-component regulatory system with ArcA
-
sensory histidine kinase in two-component regulatory system with DcuR, senses fumarate/C4-dicarboxylate
-
sensory histidine kinase in two-component regulatory system with NarP
-
sensory kinase (alternative) in two-component regulatory system with CreB (or alternatively PhoB), senses catabolite repression
-
sensory kinase in multi-component regulatory system with TorR
-
sensory kinase in two-component regulatory system with CpxR, senses misfolded proteins in bacterial envelope
-
sensory kinase in two-component regulatory system with PhoB, regulates pho regulon
-
sensory kinase in two-component regulatory system wtih KdpE, regulates kdp operon
Q8ZQW4
-
sensory transduction histidine kinase
sensory transduction protein kinase
Shk1
slr1147
sporulation kinase
sporulation kinase A (stage II sporulation protein J)
-
sporulation kinase D
SS1G_12694
subtilin biosynthesis sensor protein spaK
tetrathionate reductase complex: sensory transduction histidine kinase
-
TMAO reductase S
TorS
transmembrane sensor histidine kinase transcription regulator protein
Q8XVU1
-
tricarboxylic transport: regulatory protein
-
trimethylamine-N-oxide reductase S
TWO component response regulator transcription regulator protein
-
two component system histidine kinase
two-component histidine kinase
two-component sensor kinase
-
two-component sensor kinase yesM
two-component system histidine kinase
VC0622
VC_0622
VF_A0360
VicK
VicK-like protein
VirA
virulence sensor protein bvgS precursor
virulence sensor protein phoQ
-
W83 FimS
WalK
wide host range virA protein (WHR virA)
YycG
YycG kinase
additional information
aerobic respiration control sensor protein arcB
-
alkaline phosphatase synthesis sensor protein phoR
-
C4-dicarboxylate transport sensor protein dctB
-
chemotaxis protein cheA
-
chemotaxis protein cheA
-
FrzE
-
hybrid protein consisting of a CheA histidine kinase and a CheY receiver domain
HISTIDIN kinase (histidine protein kinase PlnB, sensor protein)
Q48828
-
HISTIDIN kinase (histidine protein kinase PlnB, sensor protein)
Q48828
-
-
histidine kinase
-
nitrate/nitrite sensor protein narQ
Q8Z4S5
-
nitrate/nitrite sensor protein narX
-
-
nitrogen regulation protein NR(II)
-
nitrogen regulation protein NR(II)
-
osmolarity sensor protein envZ
-
osmolarity sensor protein envZ
-
osmolarity sensor protein envZ
-
sensor histidine kinase
Q88PG3
two-component system formed by sensor histidine kinase and a response regulator
sensor histidine kinase
Q88PG3
two-component system formed by sensor histidine kinase and a response regulator
-
sensor protein basS/pmrB
-
sensor protein evgS precursor
-
sensor protein rcsC (capsular synthesis regulator)
-
sensor protein rcsC (capsular synthesis regulator)
-
sensory transduction histidine kinase
-
sensory transduction protein kinase
-
virulence sensor protein bvgS precursor
-
additional information
-
AHK5 belongs to the the canonical HK class of proteins in Arabidopsis thaliana
additional information
DcuS is a member of the periplasmic sensing histidine kinases
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
-
-
-
-
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
catalytic mechanism for Brucella LOV-HK, molecular modeling and simulations, overview
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
phospho-group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:protein-L-histidine N-phosphotransferase
This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine). A number of histones can act as acceptor.
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CAS REGISTRY NUMBER
COMMENTARY
99283-67-7
protein-histidine kinases, EC 2.7.13.1, EC 2.7.13.2, and EC 2.7.13.3 are not distinguished in Chemical Abstracts
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + histidine kinase EnvZ
ADP + histidine kinase EnvZ N-phospho-L-histidine
-
autophosphorylation. Probing catalytically essential domain orientation in histidine kinase EnvZ by targeted disulfide crosslinking
-
-
?
ATP + Spo0F protein L-histidine
ADP + Spo0F protein N-phospho-L-histidine
-
-
-
-
?
CitB + ATP
?
-
a fusion protein MalE-CitAC is composed of the maltose-binding protein and the CitA kinase domain shows constitutive autokinase activity and transfers the gamma-phosphate group of ATP to its cognate response regulator CitB
-
-
?
DcuR + ATP
?
-
the phosphoryl group of DcuS is rapidly transferred to the response regulator DcuR. Upon phosphorylation, DcuR binds specifically to dcuB promoter DNA
-
-
?
EvgA + ATP
?
-
one hybrid histidine kinase consisting of the BvgS transmitter and HPt domains and of the EvgS receiver domain BvgS-TO-EvgS-R is able to phosphorylate BvgA but not EvgA. In contrast, the hybrid protein consisting of the BvgS transmitter and the EvgS receiver and HPt domains BvgS-T-EvgS-RO is unable to phosphorylate BvgA but efficiently phosphorylates EvgA
-
-
?
Rcp1 + ATP
?
-
Cph1 is a light-regulated histidine kinase that mediates red, far-red reversible phosphorylation of the a small response regulator Rcp1
-
-
?
TorR + ATP
?
-
TorS is a sensor that contains three phosphorylation sites and transphosphorylates TorR via a four-step phosphorelay, His443 to Asp723 to His850 to Asp(TorR). TorS can dephosphorylate phospho-TorR when trimethylamine N-oxide is removed. Dephosphorylation probably occurs by a reverse phosphorelay, Asp(TorR) to His850 to Asp723
-
-
?
ArcA + ATP
?
-
ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response regulator ArcA through a His to Asp to His to Asp phosphorelay pathway
-
-
?
ArcA + ATP
?
-
ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response regulator ArcA through a His to Asp to His to Asp phosphorelay pathway
-
-
-
ArcA + ATP
?
-
the arcB gene encodes a sensor-regulator protein for anaerobic repression of the arc modulon
-
-
-
ArcA + ATP
?
-
the ArcB and ArcA proteins constitute a two-component signal transduction system that plays a broad role in transcriptional regulation. Under anoxic or environmentally reducing conditions, the sensor kinase ArcB is stimulated to autophosphorylate at the expense of ATP and subsequently transphosphorylates the response regulator ArcA
-
-
-
ArcA + ATP
?
-
phosphoryl group transfer from phosphorylated ArcB to ArcA, signal transmission occurs solely by His-Asp-His-Asp phosphorelay
-
-
-
ATP + a protein
ADP + a phosphoprotein
-
the two-component sensory transduction system chvG/chvI is required for virulence of Agrobacterium tumefaciens
-
-
-
ATP + a protein
ADP + a phosphoprotein
Agrobacterium tumefaciens C58 / ATCC 33970
-
the two-component sensory transduction system chvG/chvI is required for virulence of Agrobacterium tumefaciens
-
-
-
ATP + a protein
ADP + a phosphoprotein
-
kinase of the alternate pathway for phosphorylating the SpoOF protein
-
-
-
ATP + a protein
ADP + a phosphoprotein
-
the essential two-component regulatory system yycF/yycG modulates expression of the ftsAZ operon in Bacillus subtilis
-
-
-
ATP + a protein
ADP + a phosphoprotein
-
the two-component signal transduction system yycF/yycG is essential for growth of Bacillus subtilis
-
-
-
ATP + a protein
ADP + a phosphoprotein
regulation of the levels of OmpF and OmpC is normally controlled by a multicomponent signal-transducing regulatory pair of proteins, EnvZ and OmpR. The effect RprX and RprY have on OmpF expression is mediated at the level of transcription. Thus, RprX and RprY may be interfering with the normal regulation of OmpF by OmpR and EnvZ
-
-
-
ATP + a protein
ADP + a phosphoprotein
-
the tyrosine kinase DivL function in cell cycle and developmental regulation is mediated, at least in part, by the global response regulator CtrA, the enzyme is essential for cell viability and division
-
-
-
ATP + a protein
ADP + a phosphoprotein
the two-component regulatory system CzcS/CzcR is involved in transcriptional control of heavy-metal homoeostasis in Alcaligenes eutrophus
-
-
-
ATP + a protein
ADP + a phosphoprotein
Deinococcus radiodurans bacteriophytochrome functions as a light-regulated histidine kinase, which helps protect the bacterium from visible light
-
-
-
ATP + a protein
ADP + a phosphoprotein
the two-component regulatory system VanS-VanR activates a promoter used for cotranscription of the vanH, vanA, and vanX resistance genes
-
-
-
ATP + a protein
ADP + a phosphoprotein
the two-component regulatory system VanS-VanR activates a promoter used for cotranscription of the vanH, vanA, and vanX resistance genes
-
-
-
ATP + a protein
ADP + a phosphoprotein
enzyme is involved in signal transduction controlling chemotaxis
-
-
-
ATP + a protein
ADP + a phosphoprotein
-
photosynthesis gene expression in Rhodobacter sphaeroides is controlled in part by the two-component regulatory system composed of a membrane-bound sensor kinase PrrB and a response regulator PrrA
-
-
-
ATP + a protein
ADP + a phosphoprotein
-
regB is part of a two-component system and encodes a sensor kinase involved in the global regulation of both anoxygenic light-dependent- and oxygenic light-independent CO2 fixation as well as anoxygenic photosystem biosynthesis
-
-
-
ATP + a protein
ADP + a phosphoprotein
enzyme is involved in chemotaxis
-
-
-
ATP + a protein
ADP + a phosphoprotein
PrrB is responsive to the removal of oxygen and functions through the response regulator PrrA. Together, prrB and prrA provide the major signal involved in synthesis of the specialized intracytoplasmic membrane, harboring components essential to the light reactions of photosynthesis. PrrB is a global regulator of photosynthesis gene expression
-
-
-
ATP + a protein
ADP + a phosphoprotein
-
enzyme is involved in chemotaxis
-
-
-
ATP + a protein
ADP + a phosphoprotein
enzyme is involved in early steps of competence regulation
-
-
-
ATP + CovR L-histidine
ADP + CovR N-phospho-L-histidine
-
-
-
-
?
ATP + DraR L-histidine
ADP + DraR N-phospho-L-histidine
-
autophosphorylation of DraK and subsequent phosphotransfer to its cognate response regulator protein DraR
-
-
?
ATP + DraR L-histidine
ADP + DraR N-phospho-L-histidine
-
-
-
?
ATP + DraR L-histidine
ADP + DraR N-phospho-L-histidine
autophosphorylation of DraK and subsequent phosphotransfer to its cognate response regulator protein DraR
-
-
?
ATP + histidine kinase Hik34
ADP + histidine kinase Hik34 N-phospho-L-histidine
-
histidine kinase Hik34 might negatively regulate the expression of certain heat shock genes that might by related to thermotolerance in Synechocystis
-
-
?
ATP + histidine kinase Hik34
ADP + histidine kinase Hik34 N-phospho-L-histidine
-
autophosphorylation, in vitro at physiological temperatures, but not at elevated temperatures, such as 44°C
-
-
?
ATP + PhoN protein L-histidine
ADP + PhoN protein N-phospho-L-histidine
-
-
-
-
?
ATP + PhoN protein L-histidine
ADP + PhoN protein N-phospho-L-histidine
-
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
AtBphP1 contains a typical two-component histidine kinase domain at its C-terminus whose activity is repressed after photoconversion to Pfr
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
AtBphP2 is repressed after photoconversion to Pr
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
the two-component histidine kinase alrO117 is involved in heterocyst development
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
canonical histidine kinase activity of the transmitter domain of the ETR1 ethylene receptor from Arabidopsis is not required for signal transmission
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
histidine kinase BA1351
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
histidine kinase BA1356 is capable of inducing sporulation
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
histidine kinase BA1478
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
histidine kinase BA2291 acts as a phosphatase on the sporulation phosphorelay
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
histidine kinase BA2636
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
histidine kinase BA2644
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
histidine kinase BA3702
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
histidine kinase BA4223 is capable of inducing sporulation in Bacillus anthracis
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
histidine kinase BA5029
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
histidine kinases DivJ and PleC initiate signal transduction pathways that regulate an early cell division cycle step and the gain of motility later in the Caulobacter crescentus cell cycle
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
RodK may regulate multiple temporally separated events during fruiting body formation including stimulation of early developmental gene expression, inhibition of A-signal production and inhibition of the intercellular C-signal transduction pathway
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
the gene-disrupted mutant is unable to produce normal mature fruiting bodies and produces fewer spores
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
induced by dehydration and CaCl2. NTHK2 possesses Ser/Thr kinase activity in presence of Mn2+ and histidine kinase activity in presence of Ca2+
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
Streptococcus pyogenes MGAS2221
-
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
histidine kinase CikA resets the circadian clock
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
the circadian clock-associated histidine kinase SasA is necessary for rubustness of the circadian rhythm of gene expression and involved in clock output
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
Q55586
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
in Synechocystis sp. PCC 6803 four histidine kinases, Hik16, Hik33, Hik34, and Hik41, perceive and transduce salt signals
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
in Synechocystis sp. PCC 6803 four histidine kinases, Hik16, Hik33, Hik34, and Hik41, perceive and transduce salt signals. The Hik16/Hik41 system responds only to NaCl
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
the three-component system of histidine kinases and response regulator, His16-Hik41-Rre17, acts as transducer of hyperosmotic stress
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
the two-component system of histidine kinase and response regulator, His10-Rre3, acts as transducer of hyperosmotic stress
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
the two-component system of histidine kinase and response regulator, His33-Rre31, acts as transducer of hyperosmotic stress
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
the two-component systes of histidine kinase and response regulator, His34-Rre1, acts as transducer of hyperosmotic stress
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
-
the two active sites of CheA homodimers exhibit large differences in their interactions with ATP
-
-
?
ATP + Spo0A L-histidine
ADP + Spo0A N-phospho-L-histidine
-
-
-
?
ATP + VicR L-histidine
ADP + VicR N-phospho-L-histidine
-
-
-
?
ATP + VicR protein L-histidine
ADP + VicR protein N-phospho-L-histidine
-
-
-
?
ATP + VicR protein L-histidine
ADP + VicR protein N-phospho-L-histidine
Streptococcus pneumoniae D39 / ATCC 7466
-
-
-
?
ATP + YycF
ADP + phospho-YycF
the formation of the division septum is necessary for YycG phosphorylation of YycF
-
-
?
ATP + YycF
ADP + phospho-YycF
a response regulator/transcription factor
-
-
?
BvgA + ATP
?
-
the phosphorylated, purified C-terminal domain alone is sufficient for phosphotransfer to BvgA
-
-
?
BvgA + ATP
?
-
one hybrid histidine kinase consisting of the BvgS transmitter and HPt domains and of the EvgS receiver domain BvgS-TO-EvgS-R is able to phosphorylate BvgA but not EvgA. In contrast, the hybrid protein consisting of the BvgS transmitter and the EvgS receiver and HPt domains BvgS-T-EvgS-RO is unable to phosphorylate BvgA but efficiently phosphorylates EvgA
-
-
?
GTP + protein-L-histidine
GDP + protein N-phospho-L-histidine
Q81QX4
the enzyme is involved the transition between the vegetative cycle and sporulation, multiple sensor histidine kinases are induced to autophosphorylate in response to sporulation specific signals in the phosphorelay, the BA2291 protein may act as a phosphatase on the sporulation phosphorelay when present at elevated levels, overview
-
-
r
GTP + protein-L-histidine
GDP + protein N-phospho-L-histidine
Q81QX4
BA2291 is absolutely specific for guanine nucleotides in both the forward and reverse reactions, nucleotide specificity of BA2291, overview
-
-
r
GTP + protein-L-histidine
GDP + protein N-phospho-L-histidine
Q81QX4
the enzyme is involved the transition between the vegetative cycle and sporulation, multiple sensor histidine kinases are induced to autophosphorylate in response to sporulation specific signals in the phosphorelay, the BA2291 protein may act as a phosphatase on the sporulation phosphorelay when present at elevated levels, overview
-
-
r
GTP + protein-L-histidine
GDP + protein N-phospho-L-histidine
Q81QX4
BA2291 is absolutely specific for guanine nucleotides in both the forward and reverse reactions, nucleotide specificity of BA2291, overview
-
-
r
GTP + Spo0F L-histidine
GDP + Spo0F N-phospho-L-histidine
Q81QX4
a protein purified from Bacillus subtilis
-
-
r
GTP + Spo0F L-histidine
GDP + Spo0F N-phospho-L-histidine
Q81QX4
a protein purified from Bacillus subtilis
-
-
r
protein + ATP
?
-
the cytoplasmic portion of BvgS autophosphorylates with the gamma-phosphate from [gamma-32P]ATP
-
-
?
protein + ATP
?
-
DivL protein is homologous to the ubiquitous bacterial histidine protein kinases, it differs from previously studied members of this protein kinase family in that it contains a tyrosine residue Tyr550 in the conserved H-box instead of a histidine residue, which is the expected site of autophosphorylation. DivL is autophosphorylated on Tyr-550 in vitro, and this tyrosine residue is essential for cell viability and regulation of the cell division cycle
-
-
?
protein + ATP
?
-
autophosphorylation
-
-
?
protein + ATP
?
-
H243 is a site of autophosphorylation as well as transphosphorylation to the conserved D55 residue of response regulator OmpR
-
-
?
protein + ATP
?
-
a model of the mechanism of FrzE phosphorylation: autophosphorylation initially occurs at a conserved His residue within the "CheA" domain and then, via an intramolecular transphosphorylation, is transferred to a conserved aspartate residue within the "CheY" domain
-
-
?
regulator protein OmpR + ATP
?
-
H243 is the a site of autophosphorylation as well as transphosphorylation to the conserved D55 residue of response regulator OmpR
-
-
?
additional information
?
-
it is proposed that VirA acts as an environmental sensor of plant-derived inducer molecules and transmits this information to the level of vir gene expression
-
-
-
additional information
?
-
it is proposed that VirA acts as an environmental sensor of plant-derived inducer molecules and transmits this information to the level of vir gene expression
-
-
-
additional information
?
-
membrane-bound sensor of plant signal molecules
-
-
-
additional information
?
-
membrane-bound sensor of plant signal molecules
-
-
-
additional information
?
-
AaHSK1 may interact with AaHOG1 at post-translational levels
-
-
-
additional information
?
-
AaHSK1 may interact with AaHOG1 at post-translational levels
-
-
-
additional information
?
-
AlHK1p is important for, but not the sole factor responsible for Alternaria longipes resistance to dicarboximide fungicides, e.g. dimethachlon, molecular basis of the fungicide resistance, overview
-
-
-
additional information
?
-
AlHK1p is important for, but not the sole factor responsible for Alternaria longipes resistance to dicarboximide fungicides, e.g. dimethachlon, molecular basis of the fungicide resistance, overview
-
-
-
additional information
?
-
AlHK1p is important for, but not the sole factor responsible for Alternaria longipes resistance to dicarboximide fungicides, e.g. dimethachlon, molecular basis of the fungicide resistance, overview
-
-
-
additional information
?
-
AlHK1p is important for, but not the sole factor responsible for Alternaria longipes resistance to dicarboximide fungicides, e.g. dimethachlon, molecular basis of the fungicide resistance, overview
-
-
-
additional information
?
-
AlHK1p is important for, but not the sole factor responsible for Alternaria longipes resistance to dicarboximide fungicides, e.g. dimethachlon, molecular basis of the fungicide resistance, overview
-
-
-
additional information
?
-
AlHK1p is important for, but not the sole factor responsible for Alternaria longipes resistance to dicarboximide fungicides, e.g. dimethachlon, molecular basis of the fungicide resistance, overview
-
-
-
additional information
?
-
AlHK1p is important for, but not the sole factor responsible for Alternaria longipes resistance to dicarboximide fungicides, e.g. dimethachlon, molecular basis of the fungicide resistance, overview
-
-
-
additional information
?
-
histidine kinase domain and response regulator domain form a two-component system
-
-
-
additional information
?
-
histidine kinase domain and response regulator domain form a two-component system
-
-
-
additional information
?
-
histidine kinase domain and response regulator domain form a two-component system
-
-
-
additional information
?
-
histidine kinase domain and response regulator domain form a two-component system
-
-
-
additional information
?
-
histidine kinase domain and response regulator domain form a two-component system
-
-
-
additional information
?
-
histidine kinase domain and response regulator domain form a two-component system
-
-
-
additional information
?
-
histidine kinase domain and response regulator domain form a two-component system
-
-
-
additional information
?
-
ETR1 acts as an ethylene receptor
-
-
-
additional information
?
-
-
histidine kinases are part of two-component signal transduction systems that act to integrate environmental stimuli into a cellular response via a phosphotransfer relay mechanism, e.g. involved in stomatal guard cell response to H2O2, regulation of the physiological function, overview
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-
-
additional information
?
-
-
the enzyme performs regulatory autophosphorylation
-
-
-
additional information
?
-
CKI1 interacts with proteins AHP2 and AHP3, but CKI1 is incapable of binding to cytokinins
-
-
-
additional information
?
-
CKI1 interacts with proteins AHP2 and AHP3, but CKI1 is incapable of binding to cytokinins
-
-
-
additional information
?
-
the two-component regulatory system, NtrY/NtrX is involved in nitrogen fixation and metabolism. NtrY is likely to represent the transmembrane sensor protein element in a two-component regulatory system
-
-
-
additional information
?
-
Q81QX4
genes for orthologs of the sensor domain of the BA2291 kinase exist in virulence plasmids in this organism, and these proteins, when expressed, inhibit sporulation by converting BA2291 to an apparent phosphatase of the sporulation phosphorelay
-
-
-
additional information
?
-
Q81QX4
BA2291 performs GTP-dependent autophosphorylation
-
-
-
additional information
?
-
Q81QX4
genes for orthologs of the sensor domain of the BA2291 kinase exist in virulence plasmids in this organism, and these proteins, when expressed, inhibit sporulation by converting BA2291 to an apparent phosphatase of the sporulation phosphorelay
-
-
-
additional information
?
-
Q81QX4
BA2291 performs GTP-dependent autophosphorylation
-
-
-
additional information
?
-
-
mediates the transfer of phosphate to the Spo0A and Spo0F sporulation regulatory proteins. Spo0F protein is a much better phosphoreceptor for this kinase than Spo0A protein in vitro
-
-
-
additional information
?
-
two-component regulatory system CssR-CssS, is required for the cell to survive the severe secretion stress caused by a combination of high-level production of the alpha-amylase AmyQ and reduced levels of the extracytoplasmic folding factor PrsA. The Css system is required to degrade misfolded exported proteins at the membrane-cell wall interface. CssS represents the first identified sensor for extracytoplasmic protein misfolding in a Gram-positive eubacterium
-
-
-
additional information
?
-
-
the CitST two-component system regulates the expression of the Mg-citrate transporter in Bacillus subtilis
-
-
-
additional information
?
-
-
mediates the transfer of phosphate to the Spo0A and Spo0F sporulation regulatory proteins
-
-
-
additional information
?
-
enzyme is responsible for regulation of subtilin biosynthesis
-
-
-
additional information
?
-
-
enzyme is responsible for regulation of subtilin biosynthesis
-
-
-
additional information
?
-
-
activation role for ResD, and to a lesser extent ResE, in global regulation of aerobic and anaerobic respiration in Bacillus subtilis
-
-
-
additional information
?
-
the N-terminal Per-ARNT-Sim domain plays a critical role in the catalytic activity of this enzyme, a significant decrease occurs of the autophosphorylation rate of a KinA protein lacking this domain
-
-
-
additional information
?
-
The sensor histidine kinase YycG acts in a two-component system with response regulator/transcription factor YycF in Bacillus subtilis controling the synthesis of autolysins and autolysin inhibitors, that function in cell wall remodelling and cell separation, YycG sensor histidine kinase is a component of and perceives infirmation at the division septum in growing cells constituting a positive feedback loop, that serves to co-ordinate cell division with cell wall homeostasis, overview
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-
-
additional information
?
-
-
the enzyme performs catalytic autophosphorylation, mechanism and kinetics, overview. DesK displays a compact structure at the ATP-binding pocket: the ATP lid loop is short with no secondary structural organization and becomes ordered upon ATP loading. Sequence conservation mapping onto the molecular surface, semi-flexible protein-protein docking simulations, and structure-based point mutagenesis present a specific domain-domain geometry during autophosphorylation catalysis. In vitro, DesKC catalyzes three different reactions depending on the phosphorylation states of the partners: its own phosphorylation, phosphotransfer to DesR, and dephosphorylation of phospho-DesR. Protein-protein docking and modelling of the enzyme in autophosphorylation state, residues involved in domain-domain interaction modulate catalysis, overview
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-
-
additional information
?
-
-
YycG interacts with the latter stage cell division proteins DivIB, Pbp2B and FtsL
-
-
-
additional information
?
-
the enzyme performs catalytic autophosphorylation, mechanism and kinetics, overview. DesK displays a compact structure at the ATP-binding pocket: the ATP lid loop is short with no secondary structural organization and becomes ordered upon ATP loading. Sequence conservation mapping onto the molecular surface, semi-flexible protein-protein docking simulations, and structure-based point mutagenesis present a specific domain-domain geometry during autophosphorylation catalysis. In vitro, DesKC catalyzes three different reactions depending on the phosphorylation states of the partners: its own phosphorylation, phosphotransfer to DesR, and dephosphorylation of phospho-DesR. Protein-protein docking and modelling of the enzyme in autophosphorylation state, residues involved in domain-domain interaction modulate catalysis, overview
-
-
-
additional information
?
-
the N-terminal Per-ARNT-Sim domain plays a critical role in the catalytic activity of this enzyme, a significant decrease occurs of the autophosphorylation rate of a KinA protein lacking this domain
-
-
-
additional information
?
-
KinA performs autophosphorylation
-
-
-
additional information
?
-
YycG interacts with the latter stage cell division proteins DivIB, Pbp2B and FtsL
-
-
-
additional information
?
-
-
bvgS and bvgA control the expression of the virulence-associated genes in Bordetella species by a system similar to the two-component systems used by a variety of bacterial species to respond to environmental stimuli
-
-
-
additional information
?
-
NodV and NodW proteins are members of the family of two-component regulatory systems, NodV responds to an environmental stimulus and, after signal transduction, NodW may be required to positively regulate the transcription of one or several unknown genes involved in the nodulation process
-
-
-
additional information
?
-
-
the enzyme is a biological oxygen sensors that restricts the expression of specific genes to hypoxic conditions
-
-
-
additional information
?
-
-
FixL and FixJ proteins are members of the two-component sensor/regulator family
-
-
-
additional information
?
-
-
upon illumination in the presence of ATP, the enzyme undergoes autophosphorylation
-
-
-
additional information
?
-
LOVHK is able to phosphotransfer to the central regulator of the GSR system in Brucella, specific interaction with its cognate response regulators
-
-
-
additional information
?
-
LOVHK is able to phosphotransfer to the central regulator of the GSR system in Brucella, specific interaction with its cognate response regulators
-
-
-
additional information
?
-
-
upon illumination in the presence of ATP, the enzyme undergoes autophosphorylation
-
-
-
additional information
?
-
-
autophosphorylation occurs when the ATP molecule bound to the the catalytic and ATP-binding subdomain phosphorylates the histidine residue in the dimerization/histidine phosphoacceptor subdomain. Histidine kinase dimerization implies that the directionality of the autophosphorylation reaction can proceed either in a cis (intramolecular) or in a trans (intermolecular) manner. Autophosphorylation occurs in cis in the dimer. Intramolecular interactions in the enzyme, overview. Arg321 from the alpha2 helix of the dimerization/histidine phosphoacceptor subdomain contacts Glu384, Tyr383 and the gamma phosphate from non-hydrolyzable ATP analogue AMP-PCP, closing the binding pocket
-
-
-
additional information
?
-
the two-component regulatory system irlR-irlS is involved in invasion of eukaryotic cells and heavy-metal resistance in Burkholderia pseudomallei
-
-
-
additional information
?
-
the two-component regulatory system irlR-irlS is involved in invasion of eukaryotic cells and heavy-metal resistance in Burkholderia pseudomallei
-
-
-
additional information
?
-
-
Cek1p phosphorylation via Sho1p does not require histidine kinase Chk1p
-
-
-
additional information
?
-
-
Cek1p phosphorylation via Sho1p does not require histidine kinase Chk1p
-
-
-
additional information
?
-
measurement of the enzyme's ATPase activity
-
-
-
additional information
?
-
-
autophosphorylation of MtrB-Strep in proteoliposomes in the presence of ATP
-
-
-
additional information
?
-
-
Cm-ETR1 mRNA is very high in the seeds and placenta. Marked increase of Cm-ETR1 mRNA parallels climacteric ethylene production. Cm-ETR1 plays a specific role not only in ripening but also in the early development of melon fruit
-
-
-
additional information
?
-
Cm-ETR1 mRNA is very high in the seeds and placenta. Marked increase of Cm-ETR1 mRNA parallels climacteric ethylene production. Cm-ETR1 plays a specific role not only in ripening but also in the early development of melon fruit
-
-
-
additional information
?
-
-
the VanR B-VanS B two-component regulatory system activates a promoter located immediately downstream from the vanS B gene
-
-
-
additional information
?
-
-
the sensory histidine kinase acts in the two-component system with the response regulator as RR-HK17, EF1633-EF1632, in the regulation of ethanolamine utilization, which can be the sole carbon source for the organism, mechanism, overview
-
-
-
additional information
?
-
-
RcsC is the sensor components of the two-component regulatory system which regulates expression of the slime polysaccharide colanic acid. rcs system is essential for expression of high levels of the group I capsular polysaccharide in lon+ E. coli K30
-
-
-
additional information
?
-
-
upon illumination in the presence of ATP, the enzyme undergoes autophosphorylation
-
-
-
additional information
?
-
-
BarA/UvrY system activated biofilm formation. UvrY resides downstream from csrA in a signaling pathway for csrB and CsrA stimulates UvrY-dependent activation of csrB expression by BarA-dependent and BarA-independent mechanisms
-
-
-
additional information
?
-
E. coli BarA-UvrY two-component system is required for efficient switching between glycolytic and gluconeogenic carbon sources
-
-
-
additional information
?
-
-
purified BarA protein is able to autophosphorylate when incubated with [gamma-(32)P]ATP but not with [alpha-(32)P]ATP or [gamma-(32)P]GTP. Phosphorylated BarA, in turn, acts as an efficient phosphoryl group donor to UvrY. BarA and UvrY constitute a new two-component system for gene regulation in Escherichia coli
-
-
-
additional information
?
-
-
enzyme is involved in adaptive responses in E. coli
-
-
-
additional information
?
-
-
CpxA functions as a transmembrane sensory protein
-
-
-
additional information
?
-
-
EnvZ modulates expression of the ompF and ompC genes through phosphotransfer signal transduction in Escherichia coli
-
-
-
additional information
?
-
-
enzyme controls the osmoregulated biosynthesis of the porin proteins OmpF and OmpC
-
-
-
additional information
?
-
-
the enzyme plays a central role in osmoregulation, a cellular adaptation process involving the His-Asp phosphorelay signal transduction system. Dimerization of the transmembrane protein is essential for its autophosphorylation and phosphorelay signal transduction functions
-
-
-
additional information
?
-
-
the enzyme plays an important role in coupling signals received from membrane-bound receptors to changes in the swimming behavior of the cells in order to respond appropriately to environmental signals
-
-
-
additional information
?
-
-
a complex of the proteins CheA (CheAL and CheAS) and CheW constitutes a functional unit that responds to the signaling state of the chemoreceptors. The autophosphorylation rate of CheAL is much greater when CheAL and CheAS are complexed with CheW. Moreover, the presence of mutant chemoreceptors that cause cells to tumble increases this rate. At wild-type levels of expression, the isolated CheAL/CheAS/CheW complex accounts for about 10% of the total number of CheAL, CheAS, and CheW molecules and exists in a 1:1:1 stoichiometry. This complex is also required for CheAL/CheAS and CheW binding to the phosphorylation substrate, CheY
-
-
-
additional information
?
-
-
the protein is involved in osmoregulation of OmpF and OmpC. EnvZ is considered to be an osmosensor which transmits signals across the membrane to OmpR, a transcriptional activator for ompF and ompC
-
-
-
additional information
?
-
-
UhpB and perhaps UhpC play both positive and negative roles in the control of uhpT transcription
-
-
-
additional information
?
-
-
enzyme has an enhancing effect on the transcription of phoA, primary function may not be connected to the phosphate regulon
-
-
-
additional information
?
-
colanic acid capsule synthesis in Escherichia coli K-12 is regulated by RcsB and RcsC. RcsC acts as the sensor and RcsB acts as the receiver or effector to stimulate capsule synthesis from cps genes
-
-
-
additional information
?
-
the HydH/G system senses high periplasmic Zn2+ and Pb2+ concentrations and contributes to metal tolerance by activating the expression of zraP
-
-
-
additional information
?
-
-
narL and narX mediate nitrate induction of nitrate reductase synthesis and nitrate repression of fumarate reductase synthesis
-
-
-
additional information
?
-
-
enzyme is involved in signal transduction
-
-
-
additional information
?
-
-
either of two functionally redundant sensor proteins, NarX and NarQ, is sufficient for nitrate regulation in Escherichia coli K-12. NarQ and NarX may have subtle functional differences
-
-
-
additional information
?
-
-
narQ is a nitrate sensor for nitrate-dependent gene regulation in Escherichia coli
-
-
-
additional information
?
-
the two-component sensor-effector system KdpD /KdpE controls expression of the kdpABC operon
-
-
-
additional information
?
-
-
the two-component sensor-effector system KdpD /KdpE controls expression of the kdpABC operon
-
-
-
additional information
?
-
-
the TorS/TorR two-component system induces the expression of the tor structural operon encoding the trimethylamine N-oxide reductase respiratory system in response to substrate availability. TorS belongs to a sensor subfamily that includes a classical transmitter domain, a receiver, and a C-terminal alternative transmitter domain
-
-
-
additional information
?
-
-
TorS is a sensor that contains three phosphorylation sites and transphosphorylates TorR via a four-step phosphorelation, His443--Asp723--His850--Asp(TorR)
-
-
-
additional information
?
-
QseBC is a two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli strains EHEC and K-12
-
-
-
additional information
?
-
QseBC is a two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli strains EHEC and K-12
-
-
-
additional information
?
-
-
TorS mediates the induction of the tor structural genes in response to trimethylamine N-oxide
-
-
-
additional information
?
-
-
the two-component regulatory system DcuSR of Escherichia coli controls the expression of genes of C4-dicarboxylate metabolism in response to extracellular C4-dicarboxylates such as fumarate or succinate. The phosphoryl group of DcuS is rapidly transferred to the response regulator DcuR. Upon phosphorylation, DcuR binds specifically to dcuB promoter DNA
-
-
-
additional information
?
-
-
the genes encoding the anaerobic fumarate respiratory system are transcriptionally regulated by C4-dicarboxylates. The regulation is effected by a two-component regulatory system, DcuSR, consisting of a sensory histidine kinase DcuS and a response regulator DcuR
-
-
-
additional information
?
-
-
periplasmic loop of DcuS serves as a C4-dicarboxylate sensor. The cytosolic region of DcuS contains two domains: a central PAS domain possibly acting as a second sensory domain and a C-terminal transmitter domain
-
-
-
additional information
?
-
expression of cusC is induced by high concentrations of copper ions, the cusRS two-component signal transduction system is required for copper-induced expression of pcoE, a plasmid-borne gene from the E. coli copper resistance operon pco. The genes cusRS are also required for the copper-dependent expression of at least one chromosomal gene, designated cusC, which is allelic to the recently identified virulence gene ibeB in E. coli K1. The cus locus may comprise a copper ion efflux system
-
-
-
additional information
?
-
the antizyme is a bifunctional protein serving as both an inhibitor of polyamine biosynthesis as well as a transcriptional regulator of an as yet unknown set of genes
-
-
-
additional information
?
-
the two-component systemDpiA/DpiB is involved in regulation of plasmid inheritance
-
-
-
additional information
?
-
-
deletion of PilS results in a non-pilated phenotype
-
-
-
additional information
?
-
-
DcuS is the C4-dicarboxylate sensor of Escherichia coli catalyzing transmembrane sensing
-
-
-
additional information
?
-
a chemical or other stimulus is detected by the periplasmic sensor domain of a transmembrane histidine kinase sensor, which in turn relays a signal through a phosphotransfer cascade to the cognate cytoplasmic response regulator. Such systems lead ultimately to changes in gene expression or cell motility. Mechanisms of ligand binding and signal transduction through the cell membrane, overview
-
-
-
additional information
?
-
-
RcsC is the sensor components of the two-component regulatory system which regulates expression of the slime polysaccharide colanic acid. rcs system is essential for expression of high levels of the group I capsular polysaccharide in lon+ E. coli K30
-
-
-
additional information
?
-
the enzyme HP0244 is not only required to regulate flagellar gene expression via its cognate response regulator, HP0703, but also to generate a response to declining medium pH. Although not required for survival at pH 4.5, HP0244 is required for survival at pH 2.5, overview
-
-
-
additional information
?
-
the HydH/G system senses high periplasmic Zn2+ and Pb2+ concentrations and contributes to metal tolerance by activating the expression of zraP
-
-
-
additional information
?
-
enzyme is involved in regulation of the phosphate regulon
-
-
-
additional information
?
-
citrate, Na+, and oxygen exert their regulatory effects via the CitA/CitB system. In the presence of these signals, the citAB gene products induce their own synthesis. The positive autoregulation occurs via co-transcription of citAB with citS and oadGAB
-
-
-
additional information
?
-
the periplasmic domain of the histidine autokinase CitA functions as a highly specific citrate receptor
-
-
-
additional information
?
-
-
DNA sequences of plnB reveals that the product closely resembles members of bacterial two-component signal transduction systems. The finding that plnABCD are transcribed from a common promoter suggests that the biological role played by the bacteriocin is somehow related to the regulatory function of the two-component system located on the same operon
-
-
-
additional information
?
-
-
DNA sequences of plnB reveals that the product closely resembles members of bacterial two-component signal transduction systems. The finding that plnABCD are transcribed from a common promoter suggests that the biological role played by the bacteriocin is somehow related to the regulatory function of the two-component system located on the same operon
-
-
-
additional information
?
-
-
neither HK1 nor HK2 is able to autophosphorylate itself, HK1 is an ATP binding protein, acts as a functional kinase and phosphorylates HK2 by interacting with it, transfer of a phosphoryl group from HK2 to the response regulator TcrA
-
-
-
additional information
?
-
-
neither HK1 nor HK2 is able to autophosphorylate itself, HK1 is an ATP binding protein, acts as a functional kinase and phosphorylates HK2 by interacting with it, transfer of a phosphoryl group from HK2 to the response regulator TcrA
-
-
-
additional information
?
-
FrzE is a second messenger that relays information between the signaling protein FrzCD and the gliding motor
-
-
-
additional information
?
-
-
no autophosphorylation of wild-type, is caused by the rate of dephosphorylation being higher than the rate of autophosphorylation
-
-
-
additional information
?
-
Myxococcus xanthus undergoes a complex starvation-induced developmental program that results in cells forming multicellular fruiting bodies by aggregating into mounds and then differentiating into spores. This developmental program involves EspA, which plays a key role in the timing of expression of genes necessary for progression of cells through the developmental program, overview
-
-
-
additional information
?
-
-
FrzE autophosphorylates the kinase domain at His-49, and phosphoryl groups are transferred to aspartate residues (Asp-52 and Asp-220) in the two receiver domains of FrzA. The FrzE receiver domain inhibits autophosphorylation of the FrzE kinase domain
-
-
-
additional information
?
-
moxY is part of the two-component regulatory system controlling methanol dehydrogenase synthesis
-
-
-
additional information
?
-
PilS/PilR is a two-component transcriptional regulatory system controlling expression of type 4 fimbriae in Pseudomonas aeruginosa. PilS is a sensor protein which when stimulated by the appropriate environmental signals activates PilR through kinase activity. PilR then activates transcription of pilA, probably by interacting with RNA polymerase containing RpoN
-
-
-
additional information
?
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the two-component regulatory system PfeR/PfeS is involved in the expression of the ferric enterobactin receptor PfeA
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additional information
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deletion of PilS results in a non-pilated phenotype
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additional information
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signal transduction mechanism in the bacteriophytochrome, overview
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additional information
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structure-function relationship: the bacteriophytochrome possesses a histidine kinase domain and undergoes conformational changes during photoconversion, local structural changes originating in the photosensory domain modulate interactions between long, crossdomain signaling helices at the dimer interface and are transmitted to the spatially distant effector domain, thereby regulating its histidine kinase activity, overview
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additional information
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A two-component system comprises a histidine kinase protein or sensor mostly inserted into the inner membrane and a cognate partner known as the response regulator. The stimulus by the periplasmic or cytoplasmic detection domain of the histidine kinase protein triggers autophosphorylation on a conserved histidine residue of the transmitter domain H1. The phosphoryl group is then transferred on a conserved aspartate residue present in the receiver or D domain of the cognate response regulator. In Pseudomonas aeruginosa, the histidine kinase requires additional domains such as a receiver domain (D1) fused to the histidine kinase. Two-component system mechanism, overview
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additional information
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A two-component system comprises a histidine kinase protein or sensor mostly inserted into the inner membrane and a cognate partner known as the response regulator. The stimulus by the periplasmic or cytoplasmic detection domain of the histidine kinase protein triggers autophosphorylation on a conserved histidine residue of the transmitter domain H1. The phosphoryl group is then transferred on a conserved aspartate residue present in the receiver or D domain of the cognate response regulator. In Pseudomonas aeruginosa, the histidine kinase requires additional domains such as a receiver domain (D1) fused to the histidine kinase. Two-component system mechanism, overview
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additional information
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a two-component system comprises a histidine kinase protein or sensor mostly inserted into the inner membrane and a cognate partner known as the response regulator. The stimulus by the periplasmic or cytoplasmic detection domain of the histidine kinase protein triggers autophosphorylation on a conserved histidine residue of the transmitter domain H1. The phosphoryl group is then transferred on a conserved aspartate residue present in the receiver or D domain of the cognate response regulator. In Pseudomonas aeruginosa, the histidine kinase requires additional domains such as a receiver domain (D1) fused to the histidine kinase. Two-component system mechanism, overview. GacS is an unorthodox histidine kinase with H1/D1/H2 domains. GacA is an response regulator functioning as a transcriptional regulator, which positively and exclusively controls the expression of two unique target genes encoding two small noncoding RNAs, RsmY and RsmZ
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additional information
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a two-component system comprises a histidine kinase protein or sensor mostly inserted into the inner membrane and a cognate partner known as the response regulator. The stimulus by the periplasmic or cytoplasmic detection domain of the histidine kinase protein triggers autophosphorylation on a conserved histidine residue of the transmitter domain H1. The phosphoryl group is then transferred on a conserved aspartate residue present in the receiver or D domain of the cognate response regulator. In Pseudomonas aeruginosa, the histidine kinase requires additional domains such as a receiver domain (D1) fused to the histidine kinase. Two-component system mechanism, overview. GacS is an unorthodox histidine kinase with H1/D1/H2 domains. GacA is an response regulator functioning as a transcriptional regulator, which positively and exclusively controls the expression of two unique target genes encoding two small noncoding RNAs, RsmY and RsmZ
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additional information
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in vitro transphosphorylation of GacS H2 domain by LadS histidine kinase. The enzyme performs autophosphorylation using ATP
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additional information
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in vitro transphosphorylation of GacS H2 domain by LadS histidine kinase. The enzyme performs autophosphorylation using ATP
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additional information
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Q88PG3
significant number of genes are influenced directly or indirectly by the RoxSR two-component system. 173 genes are found showing reduced expression in EU58 (RoxSR mutant strain) in comparison to the wild type, whereas 84 genes are upregulated in the mutant
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additional information
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Q88PG3
The two-component system is implicated in redox signaling and cytochrome oxidase activity, in expression of the cell density-dependent gene ddcA and in bacterial colonization of plant surfaces. The RoxS/RoxR regulon includes genes involved in sugar and amino acid metabolism and the sulfur starvation response and elements of the respiratory chain (a cbb3 cytochrome oxidase, Fe-S clusters, and cytochrome c-related proteins) or genes participating in the maintenance of the redox balance. The RoxS/RoxR system controls a broad set of functions that have an influence on energy metabolism, such as formaldehyde and formate dehydrogenases.
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additional information
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Q88PG3
significant number of genes are influenced directly or indirectly by the RoxSR two-component system. 173 genes are found showing reduced expression in EU58 (RoxSR mutant strain) in comparison to the wild type, whereas 84 genes are upregulated in the mutant
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additional information
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Q88PG3
The two-component system is implicated in redox signaling and cytochrome oxidase activity, in expression of the cell density-dependent gene ddcA and in bacterial colonization of plant surfaces. The RoxS/RoxR regulon includes genes involved in sugar and amino acid metabolism and the sulfur starvation response and elements of the respiratory chain (a cbb3 cytochrome oxidase, Fe-S clusters, and cytochrome c-related proteins) or genes participating in the maintenance of the redox balance. The RoxS/RoxR system controls a broad set of functions that have an influence on energy metabolism, such as formaldehyde and formate dehydrogenases.
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additional information
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two-component regulatory system CopR/CopS is required for copper-inducible expression of the copper resistance operon
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additional information
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upon illumination in the presence of ATP, the enzyme undergoes autophosphorylation
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additional information
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upon illumination in the presence of ATP, the enzyme undergoes autophosphorylation
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additional information
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required for the activation of the C4-dicarboxylate transport structural gene dctA in free-living Rhizobium leguminosarum
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additional information
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the gene regulates transcription of the nifHDK operon and so limits the expression of nitrogen fixation activity to periods of low environmental concentrations of both oxygen and fixed nitrogen
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additional information
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role of the C-terminal domains in the photocycle of a light sensor histidine kinase Ppr having a photoactive yellow protein, PYP, domain as the photosensor domain, photocycles of the PYP domain of Ppr and of the full-length Ppr. The, overview
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additional information
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the two-component system regulates an osmosensing MAP kinase cascade
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additional information
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ompR-envZ is a two component regulatory system that plays an important role in the regulation of Vi polysaccharide synthesis in Salmonella typhi. One of the environmental signals for this regulation may be osmolarity
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additional information
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UhpB and perhaps UhpC play both positive and negative roles in the control of uhpT transcription
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additional information
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during bacterial chemotaxis, the binding of stimulatory ligands to chemoreceptors at the cell periphery leads to a response at the flagellar motor. Three proteins appear to be required for receptor-mediated control of swimming behavior, the products of the cheA, cheW, and cheY genes
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additional information
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enzyme is required for the proper expression of the outer membrane proteins OmpC and OmpF
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additional information
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the two-component regulatory system phoP/phoQ controls Salmonella typhimurium virulence
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additional information
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the PhoP-PhoQ system exerts a master regulatory function for preventing bacterial overgrowth within fibroblasts
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additional information
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enzyme is involved in the regulation of expression of phosphoglycerate transport in Salmonella typhimurium. pgtB and pgtC genes are involved in the induction of the pgtP expression by modulating derepressor activity
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additional information
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PgtB and PgtC polypeptides modulate PgtA activity
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additional information
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enzyme is involved in regulation of the phosphate regulon
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additional information
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regulation of nitrogen fixation genes in Rhizobium meliloti is mediated by two proteins, FixL and FixJ, in response to oxygen availability, oxygen sensor
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additional information
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FixL senses an environmental signal and transduces it to FixJ, a transcriptional activator of nif and fix genes
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additional information
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genes dctB and dctD form a two-component system which responds to the presence of C4-dicarboxylates to regulate expression of a transport protein encoded by dctA
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additional information
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in free-living cells, the regulatory dctBD genes are absolutely required for the expression of the dctA gene
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additional information
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dctB-encoded protein includes a putative periplasmic N-terminal domain that senses the presence of dicarboxylates and a C-terminal cytoplasmic domain that activates the dctD-encoded protein
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additional information
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the ExoS-ChvI two-component regulatory system regulates succinoglycan production. ChvG is the sensor protein of the ChvG-ChvI two-component regulatory system
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additional information
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in vitro autokinase activity of recombinant truncated enzyme mutant AgrCTM5-6C in N,N-dimethyldodecylamine N-oxide proteoliposomes
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additional information
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VicK performs autophosphorylation for self-activation. VicK can also act as a phosphatase dephosphorylating phosphorylated VicR
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additional information
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VicK performs autophosphorylation for self-activation. VicK can also act as a phosphatase dephosphorylating phosphorylated VicR
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additional information
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the two-component regulatory system afsQ1/afsQ2 is involved in secondary metabolism
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additional information
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the cutR-cutS operon regulates copper metabolism in Streptomyces
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additional information
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a histidine kinase plays a role not only in the phosphorylation of its cognate response regulator but also in the dephosphorylation of the phosphorylated response regulator, acting as both kinase and phosphatase
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additional information
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a histidine kinase plays a role not only in the phosphorylation of its cognate response regulator but also in the dephosphorylation of the phosphorylated response regulator, acting as both kinase and phosphatase
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additional information
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the SenS/SenR system of Streptomyces reticuli regulates the expression of the redox regulator FurS, the catalase-peroxidase CpeB and the heme-binding protein HbpS. SenS/SenR also participates in sensing redox changes, mediated by HbpS. The heme-binding protein HbpS regulates the activity of the Streptomyces reticuli iron-sensing histidine kinase SenS in a redox-dependent manner, presence of SenS/SenR leads to the synthesis of extracellular redox active proteins, overview
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additional information
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SenS performs autophosphorylation. HbpS/SenS interaction analysis, overview
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additional information
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the SenS/SenR system of Streptomyces reticuli regulates the expression of the redox regulator FurS, the catalase-peroxidase CpeB and the heme-binding protein HbpS. SenS/SenR also participates in sensing redox changes, mediated by HbpS. The heme-binding protein HbpS regulates the activity of the Streptomyces reticuli iron-sensing histidine kinase SenS in a redox-dependent manner, presence of SenS/SenR leads to the synthesis of extracellular redox active proteins, overview
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additional information
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SenS performs autophosphorylation. HbpS/SenS interaction analysis, overview
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additional information
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the enzyme is involved in chemical sensing
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additional information
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interaction of Hik2 with Rre1 and RppA, usage of recombinant N-terminally MBP-tagged proteins purified from Escherichia coli expression host
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additional information
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during autophosphorylation, histidine kinases catalyze transfer of only the gamma-phosphate from an ATP molecule to their conserved histidine residue
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additional information
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histidine kinase performs autophosphorylation. The His-containing substrate domain (P1) is sequestered by interactions that depend upon P1 of the adjacent subunit. Non-hydrolyzable ATP analogues (but not ATP or ADP) release P1 from the protein core (domains P3P4P5) and increase its mobility. Autophosphorylation is possible only when the subunit with a functional P4 domain trans phosphorylates a functional P1 domain of the opposing subunit
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additional information
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the enzyme is involved in regulation of density-dependent expression of luminescence in Vibrio harveyi
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additional information
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the enzyme is involved in regulation of density-dependent expression of luminescence in Vibrio harveyi
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additional information
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enzyme is involved in positive regulation of synthesis of extracellular enzymes and polysaccharide in Xanthomonas campestris pathovar campestris
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additional information
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full-length His-RaxH shows autophosphorylation activities
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additional information
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full-length His-RaxH shows autophosphorylation activities
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + histidine kinase Hik34
ADP + histidine kinase Hik34 N-phospho-L-histidine
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histidine kinase Hik34 might negatively regulate the expression of certain heat shock genes that might by related to thermotolerance in Synechocystis
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?
ATP + YycF
ADP + phospho-YycF
Q45614
the formation of the division septum is necessary for YycG phosphorylation of YycF
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?
Rcp1 + ATP
?
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Cph1 is a light-regulated histidine kinase that mediates red, far-red reversible phosphorylation of the a small response regulator Rcp1
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ArcA + ATP
?
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ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response regulator ArcA through a His to Asp to His to Asp phosphorelay pathway
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ArcA + ATP
?
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the arcB gene encodes a sensor-regulator protein for anaerobic repression of the arc modulon
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ArcA + ATP
?
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the ArcB and ArcA proteins constitute a two-component signal transduction system that plays a broad role in transcriptional regulation. Under anoxic or environmentally reducing conditions, the sensor kinase ArcB is stimulated to autophosphorylate at the expense of ATP and subsequently transphosphorylates the response regulator ArcA
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ArcA + ATP
?
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phosphoryl group transfer from phosphorylated ArcB to ArcA, signal transmission occurs solely by His-Asp-His-Asp phosphorelay
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ATP + a protein
ADP + a phosphoprotein
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the two-component sensory transduction system chvG/chvI is required for virulence of Agrobacterium tumefaciens
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ATP + a protein
ADP + a phosphoprotein
Agrobacterium tumefaciens C58 / ATCC 33970
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the two-component sensory transduction system chvG/chvI is required for virulence of Agrobacterium tumefaciens
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ATP + a protein
ADP + a phosphoprotein
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kinase of the alternate pathway for phosphorylating the SpoOF protein
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ATP + a protein
ADP + a phosphoprotein
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the essential two-component regulatory system yycF/yycG modulates expression of the ftsAZ operon in Bacillus subtilis
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ATP + a protein
ADP + a phosphoprotein
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the two-component signal transduction system yycF/yycG is essential for growth of Bacillus subtilis
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ATP + a protein
ADP + a phosphoprotein
Q08408
regulation of the levels of OmpF and OmpC is normally controlled by a multicomponent signal-transducing regulatory pair of proteins, EnvZ and OmpR. The effect RprX and RprY have on OmpF expression is mediated at the level of transcription. Thus, RprX and RprY may be interfering with the normal regulation of OmpF by OmpR and EnvZ
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ATP + a protein
ADP + a phosphoprotein
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the tyrosine kinase DivL function in cell cycle and developmental regulation is mediated, at least in part, by the global response regulator CtrA, the enzyme is essential for cell viability and division
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ATP + a protein
ADP + a phosphoprotein
Q44007
the two-component regulatory system CzcS/CzcR is involved in transcriptional control of heavy-metal homoeostasis in Alcaligenes eutrophus
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